Bis(4-amino­benzene­sulfonato-κO)bis­(propane-1,3-diamine-κ2 N,N′)copper(II) dihydrate

In the title compound, [Cu(C3H10N2)2(C6H6NO3S)2]·2H2O, the CuII atom lies on an inversion center and is hexa­coordinated by four N atoms from two 1,3-diamino­propane ligands and two O atoms from two 4-amino­benzene­sulfonate ligands in a trans arrangement, displaying a distorted and axially elongated octa­hedral coordination geometry, with the O atoms at the axial positions. A three-dimensional network is formed in the crystal structure through O—H⋯O, N—H⋯O and N—H⋯N hydrogen bonds

Luteoloside Inhibits Proliferation of Human Chronic Myeloid Leukemia K562 Cells by Inducing G2/M Phase Cell Cycle Arrest and Apoptosis

Purpose: To investigate the effects of luteoloside on the proliferation of human chronic myeloid leukemia K562 cells and whether luteoloside induces cell cycle arrest and apoptosis in K562 cells.Methods: Luteoloside’s cytotoxicity was assessed using a cell counting kit. Cell cycle distribution was analysed by flow cytometry after propidium iodide (PI) staining. Cell apoptosis was assayed with apoptosis detection kit and Hoechst staining followed by observation under a fluorescence microscope. The expression of cell cycle- and apoptosis-related proteins was examined by Western blot analysis.Results: Luteoloside inhibited the proliferation of K562 cells in a dose- and time- dependent manner (IC50 = 30.7 μM) with less toxicity in a normal human cell line (IC50 = 91.8 μM). Moreover, antiproliferative effect of luteoloside was accompanied with G2/M phase arrest（p ＜ 0.05 or p＜0.01） and apoptosis（p ＜ 0.01 or p ＜ 0.001）. Further studies revealed that the expression level of cyclinB1 was down-regulated by luteoloside treatment. Furthermore, luteoloside treatment also increased proapoptotic protein Bax expression and decreased anti-apoptotic protein Bcl-2 expression.Conclusion: These results suggest that the inhibitory effect of luteoloside on K562 cell proliferation is associated with inducing G2/M phase arrest and apoptosis, and that luteoloside is worth further studying for anticancer potential.Keywords: Luteoloside, Myeloid leukemia, Proliferation, Cell cycle arrest, Apoptosis, Anticance

Benzyl­aminium perchlorate–18-crown-6 (1/1)

In the title compound, C7H10N+·ClO4 −·C20H24O6, the proton­ated benzyl­amine cation forms a rotator–stator complex with the 18-crown-6 (1,4,7,10,13,16-hexa­oxacyclo­octa­deca­ne) mol­ecule via N—H⋯O hydrogen bonds. The cations are associated via weak C—H⋯π inter­actions, forming chains parallel to [011], while the perclorate anions are located between these chains

4-[(2′-Cyano­biphen­yl-4-yl)meth­yl]morpholin-4-ium tetra­fluoridoborate

In the crystal structure of the title compound, C18H19N2O+·BF4 −, bifurcated N—H⋯(F,F) hydrogen bonds link the protonated 4′-morpholine­methyl­biphenyl-2-carbonitrile cations and slightly distorted tetra­fluoro­borate anions. π–π inter­actions [centroid–centroid distance = 3.805 (3) Å] help to consolidate the packing. The dihedral angle between the benzene rings in the cation is 57.24 (11)°

catena-Poly[[silver(I)-μ-4,4′-bipyridine-κ2 N:N′] 4-[2-(4-carb­oxy­phen­yl)-1,1,1,3,3,3-hexa­fluoro­propan-2-yl]benzoate]

Assembly of the flexible dicarb­oxy­lic ligand 4-[2-(4-carboxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-yl]benzoate and 4,4′-bipyridine as co-ligand with AgI ions resulted in the formation of the polymeric title compound, {[Ag(C10H8N2)](C17H9F6O4)}n, in which the metal atoms are bridged by the 4,4′-bipyridine ligands, generating cationic chains extending along [010]. The dihedral angles between the benzene rings in the anion and the pyridine rings in the cation are 72.42 (9) and 9.36 (10)°, respectively. The mol­ecular conformation of the anion is stabilized by intra­molecular C—H⋯F hydrogen bonds. In the crystal, the anions inter­act with the cationic chains via C—H⋯O hydrogen bonds, forming layers parallel to (001), in which weak π–π stacking inter­actions [centroid–centroid distances = 3.975 (3)–4.047 (3) Å] involving the pyridine rings of adjacent 4,4′-bipyridine ligands are present. The planes are further assembled into a three-dimensional network by O—H⋯O hydrogen bonds

Evidence for self-organized criticality phenomena in prompt phase of short gamma-ray bursts

The prompt phase of gamma-ray burst (GRB) contains essential information regarding the physical nature and central engine, which are as yet unknown. In this paper, we investigate the self-organized criticality (SOC) phenomena in GRB prompt phase as done in X-ray flares of GRBs. We obtain the differential and cumulative distributions of 243 short GRB pulses, such as peak flux, FWHM, rise time, decay time, and peak time in the fourth BATSE TTE Catalog with the Markov Chain Monte Carlo (MCMC) technique. It is found that these distributions can be well described by power-law models. In particular, comparisons are made in 182 short GRB pulses in the third Swift GRB Catalog from 2004 December to 2019 July. The results are essentially consistent with those in BATSE ones. We notice that there is no obvious power-law index evolution across different energy bands for either BATSE or Swift sGRBs. The joint analysis suggests that GRB prompt phase can be explained by a Fractal-Diffusive, Self-Organized Criticality (FD-SOC) system with the spatial dimension S = 3 and the classical diffusion ? = 1. Our findings show that GRB prompt phases and X-ray flares possess the very same magnetically dominated stochastic process and mechanism.Comment: 18 pages, 10 figures, accepted for publication in ApJ

The Research of Biology Coupling Characteristics on the Shells of Haliotis discus hannai Ino

The surface morphologies, structures and materials of Haliotis discus hannai Ino shells were qualitatively studied by means of a stereoscopic microscope，a field emission scanning electronic microscopy, energy dispersive spectrometer and X-ray diffractometer, and abrasive particle wear was qualitatively and quantitatively studied by means of a pin-on-disc apparatus. The results showed that the outer layer surface of Haliotis discus hannai Ino shells was non-smooth and had some strumae or similar parallel convex wave. The shells of Haliotis discus hannai Ino are polycrystalline composites of calcium carbonate and proteins and glycoproteins and consist of the periostracum, prismatic and nacreous layers with calcite in the outer prismatic layer and aragonite in the inner nacreous layer. Nacreous layer is a natural composite comprised of calcium carbonate in the aragonite polymorph with organic macromolecules sandwiched in between, and the coupling of platelet interlocks and organic materials makes nacreous layer to be strong and tough.The abrasive particle wear tests showed that the abrasion resistance was different on the different parts of the shells, and the left of the shells possessed the highest abrasion resistance and the abrasion resistance of the shells was the lowest on the edge of the right. The nacreous layer possessed higher abrasion resistance than prismatic layer because of the coupling of structure and materials of nacreous layer. Key words: Haliotis discus hannai Ino shells; morphology; structure; materials; anti-wear; biological character; couplin