A method for rapid demolition of a crossline arch bridge: a case study

Abstract To reduce the adverse impact of demolition of the symmetrical rigid frame arch bridge overcrossing the highway with over-saturated traffic flow, a rapid demolition method based on the Self-Propelled Modular Transporter (SPMT) technique was developed in this study. The calculation formulae for reaction forces of the supporting brackets, as well as driving force and stability of SPMTs, were derived by analyzing the stability, synchronization, and influencing parameters of the cut bridge body—transport system. In addition, a monitoring system during the whole process was developed to ensure the demolition safety. An application of demolishing a crossline symmetrical rigid frame arch bridge in China within 5 h has been presented. The results showed that the proposed method can be successfully applied in real projects, leading to significant reduction in traffic impact, energy consumption, and environmental pollution

Research on Fluid Viscous Damper Parameters of Cable-Stayed Bridge in Northwest China

To optimize the aseismic performance of nonlinear fluid viscous dampers (FVD) of cable-stayed bridge in the highly seismic zone, Xigu Yellow River Bridge in northwest China is taken as an example. Nonlinear time-history analysis method is used to research on the relation among the internal forces, displacements, and damping parameters of the 650 tonnage FVD. The method of getting the minimum of binary functions is used to obtain the optimal parameters of FVD. Also, the 1 : 1 full-scale FVD model is made and used in the constitutive relation test. Then the test result of the damping parameters can be got by normal equation method. The optimized method to obtain the damping parameters is further verified. The results indicate that seismic response in key positions of the cable-stayed bridge can be reduced by installing longitudinal nonlinear FVD between the towers and girders if choosing reasonable damping parameters C and ξ. The optimal damping parameters can be calculated accurately by the proposed method of optimizing damping parameters of nonlinear FVD, and the constitutive relation test verifies the correctness of the optimization analysis method. Conclusions concerned can be applied to the design of nonlinear FVD for cable-stayed bridges

Research on Fluid Viscous Damper Parameters of Cable-Stayed Bridge in Northwest China

To optimize the aseismic performance of nonlinear fluid viscous dampers (FVD) of cable-stayed bridge in the highly seismic zone, Xigu Yellow River Bridge in northwest China is taken as an example. Nonlinear time-history analysis method is used to research on the relation among the internal forces, displacements, and damping parameters of the 650 tonnage FVD. The method of getting the minimum of binary functions is used to obtain the optimal parameters of FVD. Also, the 1 : 1 full-scale FVD model is made and used in the constitutive relation test. Then the test result of the damping parameters can be got by normal equation method. The optimized method to obtain the damping parameters is further verified. The results indicate that seismic response in key positions of the cable-stayed bridge can be reduced by installing longitudinal nonlinear FVD between the towers and girders if choosing reasonable damping parameters C and ξ. The optimal damping parameters can be calculated accurately by the proposed method of optimizing damping parameters of nonlinear FVD, and the constitutive relation test verifies the correctness of the optimization analysis method. Conclusions concerned can be applied to the design of nonlinear FVD for cable-stayed bridges

Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase

Abstract To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to chemotherapy are required. Here, we screen the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistance in liver cancer. LOXL3 depletion significantly sensitizes liver cancer cells to Oxaliplatin by inducing ferroptosis. Chemotherapy-activated EGFR signaling drives LOXL3 to interact with TOM20, causing it to be hijacked into mitochondria, where LOXL3 lysyl-oxidase activity is reinforced by phosphorylation at S704. Metabolic adenylate kinase 2 (AK2) directly phosphorylates LOXL3-S704. Phosphorylated LOXL3-S704 targets dihydroorotate dehydrogenase (DHODH) and stabilizes it by preventing its ubiquitin-mediated proteasomal degradation. K344-deubiquitinated DHODH accumulates in mitochondria, in turn inhibiting chemotherapy-induced mitochondrial ferroptosis. CRISPR-Cas9-mediated site-mutation of mouse LOXL3-S704 to D704 causes a reduction in lipid peroxidation. Using an advanced liver cancer mouse model, we further reveal that low-dose Oxaliplatin in combination with the DHODH-inhibitor Leflunomide effectively inhibit liver cancer progression by inducing ferroptosis, with increased chemotherapy sensitivity and decreased chemotherapy toxicity

Effects of Tannin Addition on Changes in Color and Anthocyanin Content of Cabernet sauvignon Wine and Their Correlation

To investigate the impact of distinct wine tannins on the color and anthocyanin composition of wine, Cabernet sauvignon was employed as the primary ingredient for the production of wine using five distinct wine tannins. The wine was then aged for 120 days. The study involved the detection and analysis of various components of wine, including total phenols, total anthocyanins, total flavanols, monomer anthocyanins, chromaticity, and sensory evaluation, throughout the process of fermentation and aging. The findings indicated that the introduction of tannin prior to alcohol fermentation might lead to a rise in the overall phenolic composition of wine, exert an influence on its color, and enhance its gustatory attributes. The BSO group (oak tannin) exhibited a conspicuous elevation in the overall phenol content, with the maximum value reaching 1850.13 mg/L. Following a 120 d aging period, it was observed that the BRE group (comprised of green tea tannin) exhibited a significantly higher b* value, indicating a yellow tone, in comparison to the other experimental groups. Additionally, the color of the BRE group was noted to be yellowish brown. Following a 120 d aging period, the a* values of the PTZ (grape seed tannin) and ECA (chestnut tannin) groups exhibited a significant increase in red tone, with a respective increase of 38.19% and 27.76% compared to the aged control group that did not contain tannin. Additionally, the colors of the tannin groups were observed to be more stable and purplish red. The findings of the correlation collinear network analysis indicated a positive correlation between the red color of wine and a majority of monomer anthocyanins (P0.6). Additionally, a negative correlation was observed between the red color of wine and certain acylated anthocyanins (namely, acetylated dimethyl alexin-3-O-glucoside, alexin-3-O-acetylated glucoside, and coumarin acylated 3'-methyl alexin-3-O-) (P0.6). In conclusion, the character of red wine could be enhanced more effectively by adding wine tannins prior to fermentation, condensed tannins derived from grape seeds produced the most effective auxiliary color

Study on the Kinetic Model of Mixed Fermentation by Adding Glutathione-Enriched Inactive Dry Yeast

In order to investigate the impact of glutathione-enriched inactive dry yeast (g-IDY) on the co-fermentation process of Torulaspora delbrueckii and Saccharomyces cerevisiae, different contents of g-IDY (0, 20, 40, and 100 mg/L) were added to the simulated liquid for fermentation. The yeast quantity, reducing sugar content, and ethanol volume fraction in the fermentation system were determined every 24 h. Nonlinear fitting of the measured values was carried out using classical Logistic, SGompertz, Boltzmann, and DoseResp models. Additionally, the aroma components of the wine were analyzed by GC-MS. The results indicate that the Logistic model performs best in terms of yeast growth kinetics, whereas the DoseResp and Boltzmann models exhibit the same fitting performance for reducing sugar consumption, both superior to the Logistic model, and the Boltzmann model shows the best-fitting performance for ethanol production. All optimal models have fitting coefficients (R2 values) above 0.99, demonstrating that different contents of g-IDY can effectively complete fermentation. Furthermore, all three fitting models can effectively describe the fermentation process using g-IDY. The use of g-IDY can increase the content of ethyl phenylacetate and phenylethanol, which can be employed to enhance the aroma of wine

Hydrophobicity of Polyacrylate Emulsion Film Enhanced by Introduction of Nano-SiO₂ and Fluorine

This study proposes to utilize modified Nano-SiO2/fluorinated polyacrylate emulsion that was synthesized with a semi-continuous starved seed emulsion polymerization to improve the hydrophobicity, thermal stability, and UV-Vis absorption of polyacrylate emulsion film. To verify the proposed method, a series inspection had been conducted to investigate the features of the emulsion film. The morphological analysis indicated that Nano-SiO2 was surrounded by a silane molecule after modification, which can efficiently prevent silica nanoparticles from aggregating. Fourier transform infrared spectra confirmed that modified SiO2 and dodecafluoroheptyl methacrylate (DFMA) were successfully introduced to the copolymer latex. The particle size of latex increased with the introduction of modified Nano-SiO2 and DFMA. UV-Vis absorption spectra revealed that modified silicon nanoparticles can improve the ultraviolet shielding effect obviously. X-ray photoelectron spectroscopy illustrated that the film⁻air interface was richer in fluorine than film section and the glass side. The contact angle of modified Nano-SiO2/fluorinated polyacrylate emulsion containing 3 wt % DFMA was 112°, slightly lower than double that of polyacrylate emulsion, indicating composite emulsion films possess better hydrophobicity. These results suggest that introducing modified Nano-SiO2 and fluorine into polyacrylate emulsion can significantly enhance the thermal stability of emulsion films

Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice

Abstract Tea polyphenols (TP) are the most biologically active components in tea, with antioxidant, antiobesity, and antitumor properties, as well as the ability to modulate the composition and function of intestinal microbiota. This experimental study evaluated the chemical constituents of polyphenols in Pu-erh (PTP) and Dian Hong tea (DHTP). It also investigated the co-regulatory effects of PTP and DHTP on intestinal flora and liver tissues in mice using 16 S rRNA gene and transcriptome sequencing. The results revealed that DHT had higher concentrations of EGC (epigallocatechin), C (catechin), EC (epicatechin), and EGCG (epigallocatechin gallate). In contrast, PT had higher concentrations of GA (gallic acid), ECG (epicatechin-3-gallate), TF (theaflavin), and TB (theabrownin). PTP and DHTP consumption significantly reduced the rates of weight gain in mice. Microbial community diversity was significantly higher in PTP and DHTP-treated mice than in the control group. Notably, beneficial microbes such as Lactobacillus increased significantly in PTP-treated mice, whereas Lachnospiraceae increased significantly in DHTP-treated mice. Both PTP and DHTP improved the activity of the antioxidant enzymes (SOD) and total antioxidant capacity (T-AOC) in the liver. The transcriptome analysis revealed that the beneficial effects of PTP and DHTP were due to changes in various metabolic pathways, the majority of which were related to antioxidant and lipid metabolism. This study discovered that PTP and DHTP had beneficial effects in mice via the gut-liver axis