Randomized and efficient time synchronization in dynamic wireless sensor networks: a gossip-consensus-based approach

This paper proposes novel randomized gossip-consensus-based sync (RGCS) algorithms to realize efficient time correction in dynamic wireless sensor networks (WSNs). First, the unreliable links are described by stochastic connections, reflecting the characteristic of changing connectivity gleaned from dynamicWSNs. Secondly, based on the mutual drift estimation, each pair of activated nodes fully adjusts clock rate and offset to achieve network-wide time synchronization by drawing upon the gossip consensus approach. The converge-to-max criterion is introduced to achieve a much faster convergence speed. The theoretical results on the probabilistic synchronization performance of the RGCS are presented. Thirdly, a Revised-RGCS is developed to counteract the negative impact of bounded delays, because the uncertain delays are always present in practice and would lead to a large deterioration of algorithm performances. Finally, extensive simulations are performed on the MATLAB and OMNeT++ platform for performance evaluation. Simulation results demonstrate that the proposed algorithms are not only efficient for synchronization issues required for dynamic topology changes but also give a better performance in term of converging speed, collision rate, and the robustness of resisting delay, and outperform other existing protocols

A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop

Insulin-like growth factor 1 receptor (IGF-1R) is important in cancer cell growth and survival and has been implicated in cancer pathophysiology and treatment. Here we report a novel function for IGF-1R in p53-dependent apoptotic response. We show that inhibition or loss of IGF-1R activity reduces translational synthesis of p53 and Mdm2 protein. Notably, IGF-1R inhibition increases p53 protein stability by reducing p53 ubiquitination and maintains p53 at low levels by decreasing p53 synthesis, thus rendering p53 insensitive to stabilization after DNA damage. The accumulation and apoptosis of DNA-damage–induced p53 is therefore reduced in Igf-1r−/− mouse embryonic fibroblasts or tumor cells treated with the IGF-1R inhibitor. Furthermore, we find that inhibition of IGF-1R reduces p53 and Mdm2 translation through a gene-specific mechanism mediated by the respective 5′ untranslated region of p53 and mdm2 messenger RNA. The eukaryotic translation initiation factor 4F complex is also involved in this translational inhibition. These results demonstrate an unexpected role for translational control by IGF-1R in p53-mediated apoptosis

An adaptive filtering method based on EMD for X-ray pulsar navigation with uncertain measurement noise

Affected by the unstable pulse radiation and the pulsar directional errors, the statistical characteristics of the pulsar measurement noise may vary with time slowly and cannot be accurately determined, which cause the filtering accuracy of the extended Kalman filter(EKF) in pulsar navigation positioning system decline sharply or even diverge. To solve this problem, an adaptive extended Kalman filtering algorithm based on the empirical mode decomposition(EMD) is proposed. In this method, the high frequency noise is separated from measurement information of pulsar by the method of EMD, and the noise variance can be estimated to update the parameters of EKF. The simulation results demonstrate that compared with conventional EKF, the proposed method can adaptively track the change of the measurement noise, and still keeps high estimation accuracy with unknown measurement noise, the positioning accuracy of the pulsar navigation is improved simultaneously

Rapid detection of sacbrood virus (SBV) by one-step reverse transcription loop-mediated isothermal amplification assay

<p>Abstract</p> <p>Background</p> <p><it>Sacbrood virus </it>(SBV) primarily infects honeybee broods, and in order to deal with the problem cost effective detection methods are required.</p> <p>Findings</p> <p>A one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for the rapid identification of SBV. The data demonstrated that, in a simple water bath, SBV RNA could be detected as early as 20 min at 65°C, and a positive amplification reaction was visible to the naked eye due to a color change brought on by the addition of nucleic acid stain SYBR Green.</p> <p>Conclusions</p> <p>The current study presents a method for the rapid and simple detection of SBV by RT-LAMP with high sensitivity and analytic specificity.</p

Efficient parameter inference for gravitational wave signals in the presence of transient noises using temporal and time-spectral fusion normalizing flow

Glitches represent a category of non-Gaussian and transient noise that frequently intersects with gravitational wave (GW) signals, exerting a notable impact on the processing of GW data. The inference of GW parameters, crucial for GW astronomy research, is particularly susceptible to such interference. In this study, we pioneer the utilization of temporal and time-spectral fusion normalizing flow for likelihood-free inference of GW parameters, seamlessly integrating the high temporal resolution of the time domain with the frequency separation characteristics of both time and frequency domains. Remarkably, our findings indicate that the accuracy of this inference method is comparable to traditional non-glitch sampling techniques. Furthermore, our approach exhibits greater efficiency, boasting processing times on the order of milliseconds. In conclusion, the application of normalizing flow emerges as pivotal in handling GW signals affected by transient noises, offering a promising avenue for enhancing the field of GW astronomy research.Comment: 13 pages, 10 figure

Estrogen Inhibits Colon Polyp Formation by Reducing Angiogenesis in a Carcinogen-Induced Rat Model

Objective. To study the effects of estrogen on colon polyp formation, proliferation, and angiogenesis on a rat model of colon cancer induced by dimethylhydrazine (DMH). Methods. Thirty-six female ovariectomized (OVX) rats were randomly divided into 3 groups: (I) control group (administrated with vehicles weekly), (II) DMH group (administrated with DMH weekly), and (III) DMH + E2 group (administrated with DMH and 17β-estradiol weekly). The incidence, volumes, and multiplicity of colon polyps in each group were evaluated. The microvessel density (MVD), the expressions of Proliferating Cell Nuclear Antigen (PCNA), and the expressions of HIF-1α and VEGF in polyps were detected in each group. Results. Estrogen reduced the multiplicity, volumes, and the PCNA expressions of DMH-induced colon polyps. The MVD in DMH + E2 group was significantly lower than that in DMH group. Estrogen treatment decreased the HIF-1α and VEGF expressions at both mRNA and protein level. Conclusion. Estrogen replacement was protective for ovariectomized rats from DMH-induced carcinogenesis, and one of the mechanisms for this was due to estrogen’s inhibitive effects on blood vessel formation by downregulating VEGF and HIF-1α expressions