TwinTex: Geometry-aware Texture Generation for Abstracted 3D Architectural Models

Coarse architectural models are often generated at scales ranging from individual buildings to scenes for downstream applications such as Digital Twin City, Metaverse, LODs, etc. Such piece-wise planar models can be abstracted as twins from 3D dense reconstructions. However, these models typically lack realistic texture relative to the real building or scene, making them unsuitable for vivid display or direct reference. In this paper, we present TwinTex, the first automatic texture mapping framework to generate a photo-realistic texture for a piece-wise planar proxy. Our method addresses most challenges occurring in such twin texture generation. Specifically, for each primitive plane, we first select a small set of photos with greedy heuristics considering photometric quality, perspective quality and facade texture completeness. Then, different levels of line features (LoLs) are extracted from the set of selected photos to generate guidance for later steps. With LoLs, we employ optimization algorithms to align texture with geometry from local to global. Finally, we fine-tune a diffusion model with a multi-mask initialization component and a new dataset to inpaint the missing region. Experimental results on many buildings, indoor scenes and man-made objects of varying complexity demonstrate the generalization ability of our algorithm. Our approach surpasses state-of-the-art texture mapping methods in terms of high-fidelity quality and reaches a human-expert production level with much less effort. Project page: https://vcc.tech/research/2023/TwinTex.Comment: Accepted to SIGGRAPH ASIA 202

Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis

Abstract Background Pancreatic cancer has a high mortality rate worldwide, and is predicted to be third leading cause of death in the near future. However, the regulatory mechanisms that inhibit the progression of pancreatic cancer remain elusive. Currently, exploring the function and mechanisms of GPCRs (G-protein coupled receptors) is an important way to discover promising therapeutic targets for cancer. Methods GPRC5A expression was measured using real-time quantitative PCR, immunohistochemistry and western blot assays. Cell proliferation and migration were assessed using CCK-8, clone formation, wound-healing and transwell assays. A cytosolic/nuclear distribution experiment was used to detect the protein location transfer. A xenograft model of pancreatic cancer was established to explore the role of GPRC5A in vivo. Results GPRC5A expression was increased in pancreatic cancer, and disruption of GPRC5A expression inhibited tumor growth in vivo. Mechanistically, GPRC5A positively regulated the transcription of YAP1 through cAMP-CREB signaling. Moreover, we show that the proliferation and migration induced by GPRC5A in pancreatic cancer could be rescued by inhibiting YAP1 expression. Conclusions GPRC5A interacts with the Hippo pathway to promote the progression of pancreatic cancer. These findings reveal an important crosstalk model and provide potential targets for pancreatic cancer therapy

Holocene climate dynamics derived from pollen record of Jiulongchi wetland in Fanjing Mountain, southwest China

An alpine wetland core was obtained to a depth of 4.0 m from the Fanjing Mountain in southwest China. Sections of the core were dated with C-14 data obtained with high resolution mass spectrometry (AMS), and Holocene climate changes were inferred by categorizing predominant tree and fern vegetation identified from pollen and spore counts at various core depths. The temperature increased during 11.9-8.0 cal ka BP, and the warmest period was during 8.0-4.6 cal ka BP. Then, it gradually became cooler during the late Holocene. Our temperature estimates were in good agreement with the previous studies of the Holocene temperature in the Asian monsoon areas. There were two relatively wet periods of 10.7-8.0 cal ka BP and 4.6-2.6 cal ka BP. There was an asynchronous precipitation trend in the south, north and southwest China, which was probably due to the different monsoon impacts. In East Asian summer monsoon (EASM) area, the monsoon precipitation gradually transgressed northward during the early to middle Holocene and regressed southward during the late Holocene. Our results will be useful to improve the understanding of the coherent spatio-temporal patterns of climate evolution in EASM region in China