A Case Study of Mass Transport during the East-West Oscillation of the Asian Summer Monsoon Anticyclone

We use ERA-Interim reanalysis, MLS observations, and a trajectory model to examine the chemical transport and tracers distribution in the Upper Troposphere and Lower Stratosphere (UTLS) associated with an east-west oscillation case of the anticyclone in 2016. The results show that the spatial distribution of water vapor (H2O) was more consistent with the location of the anticyclone than carbon monoxide (CO) at 100 hPa, and an independent relative high concentration center was only found in H2O field. At 215 hPa, although the anticyclone center also migrated from the Tibetan Mode (TM) to the Iranian Mode (IM), the relative high concentration centers of both tracers were always colocated with regions where upward motion was strong in the UTLS. When the anticyclone migrated from the TM, air within the anticyclone over Tibetan Plateau may transport both westward and eastward but was always within the UTLS. The relative high concentration of tropospheric tracers within the anticyclone in the IM was from the east and transported by the westward propagation of the anticyclone rather than being lifted from surface directly. Air within the relative high geopotential height centers over Western Pacific was partly from the main anticyclone and partly from lower levels

Path Generation for Wheeled Robots Autonomous Navigation on Vegetated Terrain

Wheeled robot navigation has been widely used in urban environments, but little research has been conducted on its navigation in wild vegetation. External sensors (LiDAR, camera etc.) are often used to construct point cloud map of the surrounding environment, however, the supporting rigid ground used for travelling cannot be detected due to the occlusion of vegetation. This often causes unsafe or not smooth path during planning process. To address the drawback, we propose the PE-RRT* algorithm, which effectively combines a novel support plane estimation method and sampling algorithm to generate real-time feasible and safe path in vegetation environments. In order to accurately estimate the support plane, we combine external perception and proprioception, and use Multivariate Gaussian Processe Regression (MV-GPR) to estimate the terrain at the sampling nodes. We build a physical experimental platform and conduct experiments in different outdoor environments. Experimental results show that our method has high safety, robustness and generalization

Towards Efficient Communications in Federated Learning: A Contemporary Survey

In the traditional distributed machine learning scenario, the user's private data is transmitted between nodes and a central server, which results in great potential privacy risks. In order to balance the issues of data privacy and joint training of models, federated learning (FL) is proposed as a special distributed machine learning with a privacy protection mechanism, which can realize multi-party collaborative computing without revealing the original data. However, in practice, FL faces many challenging communication problems. This review aims to clarify the relationship between these communication problems, and focus on systematically analyzing the research progress of FL communication work from three perspectives: communication efficiency, communication environment, and communication resource allocation. Firstly, we sort out the current challenges existing in the communications of FL. Secondly, we have compiled articles related to FL communications, and then describe the development trend of the entire field guided by the logical relationship between them. Finally, we point out the future research directions for communications in FL

Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase

<p>Abstract</p> <p>Background</p> <p>The tripartite motif (TRIM) proteins are a family of more than 70 members in human. However, only a few of them have been well studied. The TRIM proteins contain the conserved RING, B-box, coiled-coil, and SPRY domains, most of which are involved in protein ubiquitination. TRIM38 is a member of the TRIM protein family, which we studied in more detail here as its functions are largely unknown.</p> <p>Results</p> <p>Our study shows that, similar to other TRIM family members, TRIM38 is localized in the cytoplasm. TRIM38 increases ubiquitination of other cellular proteins and catalyzes self-ubiquitination. TRIM38 also promotes K63- and K48-linked ubiquitination of cellular proteins. An intact RING domain is important for the functions of TRIM38. In addition, enterovirus 71 infection induces TRIM38 degradation.</p> <p>Conclusions</p> <p>Our observations demonstrate that TRIM38 has E3 ubiquitin ligase activity and can be degraded during virus infection. These findings may provide insight into innate immune signaling pathways.</p

Self-Assembly of Mitochondria-Specific Peptide Amphiphiles Amplifying the Lung Cancer Cell Death through Targeting the VDAC1-Hexokinase-II Complex

International audienceMitochondria-targeting peptides represent an emergent approach for cancer inhibition. Here supramolecular assemblies of novel amphiphilic cell-penetrating peptides for targeting cancer cells mitochondria are reported. The employed strategy aims at amplifying the apoptotic stimuli by weakening the mitochondrial VDAC1 (voltage-dependent anion channel-1)-hexokinase-II (HK-II) interaction. Peptide engineering is performed with the N-terminus of the HK-II protein, which binds to VDAC1. First, a designed positively-charged segment (pKV) is anchored to the specific 15 aminoacid sequence (MIASHLLAYFFTELN) to yield a cell-penetrating peptide (pHK-pKV). Second, a lipid chain (Pal) is conjugated to the N-terminus of pHK-pKV in order to enhance the intracellular delivery of the HK-II scaffold. The self-assembly properties of these two synthetic peptides are investigated by synchrotron small-angle X-ray scattering (BioSAXS) and cryogenic transmission electron (cryo-TEM) imaging, which evidence the formation of nanoassemblies of ellipsoid-like shapes. Circular dichroism (CD) spectroscopy demonstrates the induction of partial α-helical structures in the amphiphilic peptides. Confocal microscopy reveals the specific mitochondrial location of Pal-pHK-pKV assemblies in human non-small cell lung cancer (NSCLC) A549 cells. The cytotoxicity and apoptotic studies indicate the enhanced bioactivity of Pal-pHK-pKV self-assembled reservoirs, which cause massive A549 cell death with regard to pHK-pKV. Whereas the half maximum inhibitory concentration (IC 50) of the Pal-pHK-pKV peptide conjugates is 6.5 μM in the A549 cancer cell line, it is higher than 50 μM for healthy human mucosal epithelial cells such as the non-cancerous NCM460 cells. The results demonstrate the potential of self-assembled lipo-peptide (HK-II-derived) conjugates as a promising strategy in cancer therapy.