521 research outputs found
Enhancing the antimicrobial potential of lanthipeptides by employing different engineering strategies
The research described in this thesis aimed to develop novel approaches to engineer lantibiotics, to control either planktonic pathogens or biofilm-infections. To expand the toolbox of engineering lantibiotics, this thesis furthermore aimed at generating a method for obtaining lanthipeptide synthetases with adapted substrate specificity by directed evolution
- …