A network approach for managing and processing big cancer data in clouds

Translational cancer research requires integrative analysis of multiple levels of big cancer data to identify and treat cancer. In order to address the issues that data is decentralised, growing and continually being updated, and the content living or archiving on different information sources partially overlaps creating redundancies as well as contradictions and inconsistencies, we develop a data network model and technology for constructing and managing big cancer data. To support our data network approach for data process and analysis, we employ a semantic content network approach and adopt the CELAR cloud platform. The prototype implementation shows that the CELAR cloud can satisfy the on-demanding needs of various data resources for management and process of big cancer data

First-principles investigation of transient dynamics of molecular devices

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Universal Conductance Fluctuations in Mesoscopic Systems with Superconducting Leads: Beyond the Andreev Approximation

We report our investigation of the sample to sample fluctuation in transport properties of phase coherent normal metal-superconductor hybrid systems. Extensive numerical simulations were carried out for quasi-one dimensional and two dimensional systems in both square lattice (Fermi electron) as well as honeycomb lattice (Dirac electron). Our results show that when the Fermi energy is within the superconducting energy gap $\Delta$, the Andreev conductance fluctuation exhibits a universal value (UCF) which is approximately two times larger than that in the normal systems. According to the random matrix theory, the electron-hole degeneracy (ehD) in the Andreev reflections (AR) plays an important role in classifying UCF. Our results confirm this. We found that in the diffusive regime there are two UCF plateaus, one corresponds to the complete electron-hole symmetry (with ehD) class and the other to conventional electron-hole conversion (ehD broken). In addition, we have studied the Andreev conductance distribution and found that for the fixed average conductance $,G>$ the Andreev conductance distribution is a universal function that depends only on the ehD. In the localized regime, our results show that ehD continues to serve as an indicator for different universal classes. Finally, if normal transport is present, i.e., Fermi energy is beyond energy gap $\Delta$, the AR is suppressed drastically in the localized regime by the disorder and the ehD becomes irrelevant. As a result, the conductance distribution is that same as that of normal systems

Transport theory in metallic films: Crossover from the classical to the quantum regime

Using the quantum-statistical approach, we have developed a unified transport theory of metallic films. A general description for the conductivity in metallic films has been rigorously formulated in the presence of both impurity scattering and surface roughness. An explicit connection between the quasiclassical and present quantum approaches is also presented. We show that the quasiclassical theory by Fuchs [Proc. Cambridge Philos. Soc. 34, 100 (1938)] and Sondheimer [Adv. PHys. 1, 1 (1952)] can be reformed to be applicable to ultrathin metallic films by introducing a treatment of the surface via angle-dependent specularity parameters and including the quantum size effect. Moreover, to the lowest-order approximation in the theory, the previous quantum-approach results and discussions have naturally been recovered. © 1995 The American Physical Society.published_or_final_versio

Current induced abnormal electroresistance effect observed in epitaxial La0.9Hf0.1MnO3 thin films

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Time-reversal-symmetry-broken quantum spin Hall effect

Quantum spin Hall (QSH) state of matter is usually considered to be protected by time-reversal (TR) symmetry. We investigate the fate of the QSH effect in the presence of the Rashba spin-orbit coupling and an exchange field, which break both inversion and TR symmetries. It is found that the QSH state characterized by nonzero spin Chern numbers $C_{\pm}=\pm 1$ persists when the TR symmetry is broken. A topological phase transition from the TR symmetry-broken QSH phase to a quantum anomalous Hall phase occurs at a critical exchange field, where the bulk band gap just closes. It is also shown that the transition from the TR symmetry-broken QSH phase to an ordinary insulator state can not happen without closing the band gap.Comment: 5 pages, 5 figure