5,6-Dihydr­oxy-1,10-phenanthrolin-1-ium chloride dihydrate

The title compound, C12H9N2O2 +·Cl−·2H2O, exhibits a layered structure which is stabilized by inter­molecular O—H⋯O, O—H⋯Cl− and N+—H⋯Cl− hydrogen bonds, and π–π inter­actions (centroid–centroid distances = 3.654 and 3.583 Å). The distances between the molecules are 3.371 and 3.294 Å

Spin alignment of vector mesons in heavy-ion collisions

Polarized quarks and antiquarks in high-energy heavy-ion collisions can lead to the spin alignment of vector mesons formed by quark coalescence. Using the relativistic spin Boltzmann equation for vector mesons derived from Kadanoff-Baym equations with an effective quark-meson model for strong interaction and quark coalescence model for hadronizaton, we calculate the spin density matrix element $\rho_{00}$ for $\phi$ mesons and show that anisotropies of local field correlations or fluctuations with respect to the spin quantization direction lead to $\phi$ meson's spin alignment. We propose that the local correlation or fluctuation of $\phi$ fields is the dominant mechanism for the observed the $\phi$ meson's spin alignment and its strength can be extracted from experimental data as functions of collision energies. The calculated transverse momentum dependence of $\rho_{00}$ agrees with STAR's data. We further predict the azimuthal angle dependence of $\rho_{00}$ which can be tested in future experiments.Comment: ReVTex 4.1, 14 pages, 4 figures. A large part of the paper has been rewritten with the focus on extracting local correlations or fluctuations of phi fields from STAR's data and predictions for dependences of $\rho_{00}$ on the transverse momentum and azimuthal angl

4-Eth­oxy-N′-propanoylpyridine-2-carbohydrazide

In the crystal structure of the title compound, C11H15N3O3, mol­ecules are linked into a chain by inter­molecular N—H⋯O hydrogen bonds

Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis

IntroductionOsteoporosis (OP) is primarily diagnosed through bone mineral density (BMD) measurements, and it often leads to fracture. Observational studies suggest that several mental diseases (MDs) may be linked to OP, but the causal direction of these associations remain unclear. This study aims to explore the potential causal association between five MDs (Schizophrenia, Depression, Alzheimer's disease, Parkinson's disease, and Epilepsy) and the risk of OP.MethodsFirst, single-nucleotide polymorphisms (SNPs) were filtered from summary-level genome-wide association studies using quality control measures. Subsequently, we employed two-sample Mendelian randomization (MR) analysis to indirectly analyze the causal effect of MDs on the risk of OP through bone mineral density (in total body, femoral neck, lumbar spine, forearm, and heel) and fractures (in leg, arm, heel, spine, and osteoporotic fractures). Lastly, the causal effect of the MDs on the risk of OP was evaluated directly through OP. MR analysis was performed using several methods, including inverse variance weighting (IVW)-random effects, IVW-fixed effects, maximum likelihood, weighted median, MR-Egger regression, and penalized weighted median.ResultsThe results did not show any evidence of a causal relationship between MDs and the risk of OP (with almost all P values > 0.05). The robustness of the above results was proved to be good.DiscussionIn conclusion, this study did not find evidence supporting the claim that MDs have a definitive impact on the risk of OP, which contradicts many existing observational reports. Further studies are needed to determine the potential mechanisms of the associations observed in observational studies

Guidezilla extension catheter for percutaneous interventional therapy of complex lesions via a transradial approach: Case series from a single-center experience

   Background: Guide catheter extension systems have become one of the most powerful tools for address­ing complex lesions during percutaneous coronary intervention (PCI), but data on a new-generation rapid exchange extension catheter — the Guidezilla catheter — are limited. Summarized herein reports on experience using the Guidezilla catheter for complex coronary lesions via a transradial approach at the documented institution an evaluation of its safety and efficacy. Methods: A total of 25 patients (19 males and 6 females) who underwent PCI via the radial approach with the Guidezilla catheter for adequate back-up support and to facilitate equipment delivery were enrolled. The clinical, angiographic and procedural data of all 26 procedures in 25 patients (1 patient underwent two PCI procedures on different lesions) were collected to evaluate the safety and efficacy of this novel equipment. Results: The mean age of the enrolled patients was 67.7 ± 8.41 years old. The mean depth of intuba­tion was 27.90 ± 12.23 mm. Stent implantation was successful in 23 out of 26 procedures (88.5%) and failed in 3 cases: 1 case of tortuosity and severe angulation in a chronic total occlusion lesion; 1 case of an existing type B dissection (NHLBI classification system for coronary artery dissection types); and 1 case in which a stent was stripped off its balloon. None of the patients experienced coronary dissection, perforation, air embolism, pressure dampening or other major complications during the procedure. Conclusions: The Guidezilla extension catheter is an effective and safe tool that provides improved back-up support and increases the success rate of PCI for complex coronary lesion by radial access