9,969 research outputs found
Quantum theory of the charge stability diagram of semiconductor double quantum dot systems
We complete our recently introduced theoretical framework treating the double
quantum dot system with a generalized form of Hubbard model. The effects of all
quantum parameters involved in our model on the charge stability diagram are
discussed in detail. A general formulation of the microscopic theory is
presented, and truncating at one orbital per site, we study the implication of
different choices of the model confinement potential on the Hubbard parameters
as well as the charge stability diagram. We calculate the charge stability
diagram keeping three orbitals per site and find that the effect of additional
higher-lying orbitals on the subspace with lowest-energy orbitals only can be
regarded as a small renormalization of Hubbard parameters, thereby justifying
our practice of keeping only the lowest-orbital in all other calculations. The
role of the harmonic oscillator frequency in the implementation of the Gaussian
model potential is discussed, and the effect of an external magnetic field is
identified to be similar to choosing a more localized electron wave function in
microscopic calculations. The full matrix form of the Hamiltonian including all
possible exchange terms, and several peculiar charge stability diagrams due to
unphysical parameters are presented in the appendix, thus emphasizing the
critical importance of a reliable microscopic model in obtaining the system
parameters defining the Hamiltonian.Comment: 19 pages, 15 figure
Suppression of high hadron spectra in collisions
Multiple hard and semi-hard parton scatterings in high-energy
collisions involve multi-parton correlation in both momentum and flavor inside
the projectile proton which will lead to modification of the final hadron
spectra relative to that in collisions. Such modification of final hadron
transverse momentum spectra in collisions is studied within HIJING 2.1
Monte Carlo model which includes nuclear shadowing of the initial parton
distributions and transverse momentum broadening. Multi-parton flavor and
momentum correlation inside the projectile are incorporated through flavor and
momentum conservation which are shown to modify the flavor content and momentum
spectra of final partons and most importantly lead to suppression of large
hadron spectra in collisions at both RHIC and LHC energies.Comment: 4 pages, 3 figures, talk given at the 5th international conference on
Hard and Electromagnetic Probes of High Energy nuclear Collisions (Hard
Probes 2012
Deciphering cancer heterogeneity: the biological space
Most lethal solid tumors including hepatocellular carcinoma (HCC) are considered incurable due to extensive heterogeneity in clinical presentation and tumor biology. Tumor heterogeneity may result from different cells of origin, patient ethnicity, etiology, underlying disease and diversity of genomic and epigenomic changes which drive tumor development. Cancer genomic heterogeneity thereby impedes treatment options and poses a significant challenge to cancer management. Studies of the HCC genome have revealed that although various genomic signatures identified in different HCC subgroups share a common prognosis, each carries unique molecular changes which are linked to different sets of cancer hallmarks whose misregulation has been proposed by Hanahan and Weinberg to be essential for tumorigenesis. We hypothesize that these specific sets of cancer hallmarks collectively occupy different tumor biological space representing the misregulation of different biological processes. In principle, a combination of different cancer hallmarks can result in new convergent molecular networks that are unique to each tumor subgroup and represent ideal druggable targets. Due to the ability of the tumor to adapt to external factors such as treatment or changes in the tumor microenvironment, the tumor biological space is elastic. Our ability to identify distinct groups of cancer patients with similar tumor biology who are most likely to respond to a specific therapy would have a significant impact on improving patient outcome. It is currently a challenge to identify a particular hallmark or a newly emerged convergent molecular network for a particular tumor. Thus, it is anticipated that the integration of multiple levels of data such as genomic mutations, somatic copy number aberration, gene expression, proteomics, and metabolomics, may help us grasp the tumor biological space occupied by each individual, leading to improved therapeutic intervention and outcome
The clinical potential of microRNAs
MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. In addition, microRNAs have been associated with cancer progression. In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed
Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is a malignant cancer with an observable heterogeneity and microRNAs are functionally associated with the tumorigenesis of HCC. We recently identified that EpCAM (CD326)-positive cells isolated from alpha-fetoprotein (AFP)-positive HCC samples are hepatic cancer stem cells (HepCSCs). EpCAM<sup>+</sup>AFP<sup>+ </sup>HepCSCs have an activated Wnt/β-catenin signaling with a parallel increased expression of all four microRNA-181 family members. We hypothesized that Wnt/β-catenin signaling transcriptionally activates microRNA-181s in HCC.</p> <p>Results</p> <p>Using both western blot and quantitative reverse transcriptase-PCR analyses, we found that the expression of all four microRNA-181 family members was positively correlated with β-catenin expression in HCC cell lines. MicroRNA-181 expression could be directly induced upon an activation of Wnt/β-catenin signaling, which includes Wnt10B overexpression, inhibition of GSK3β signaling by LiCl, or forced expression of β-catenin/Tcf4. Moreover, microRNA-181 expression was inhibited upon an inactivation of Wnt/β-catenin signaling by an induction of adenomatosis polyposis coli (APC) expression or silencing β-catenin via RNA interference. In addition, seven putative β-catenin/Tcf4 binding sites were identified in the promoter region of the microRNA-181a-2 and microRNA-181b-2 transcripts. Consistently, we found that Tcf4 interacted with these regions <it>in vivo </it>using chromatin immunoprecipitation assay.</p> <p>Conclusions</p> <p>Taken together, our results demonstrate that microRNA-181s are transcriptionally activated by the Wnt/beta-catenin signaling pathway in HCC.</p
Retinal oscillations carry visual information to cortex
Thalamic relay cells fire action potentials that transmit information from
retina to cortex. The amount of information that spike trains encode is usually
estimated from the precision of spike timing with respect to the stimulus.
Sensory input, however, is only one factor that influences neural activity. For
example, intrinsic dynamics, such as oscillations of networks of neurons, also
modulate firing pattern. Here, we asked if retinal oscillations might help to
convey information to neurons downstream. Specifically, we made whole-cell
recordings from relay cells to reveal retinal inputs (EPSPs) and thalamic
outputs (spikes) and analyzed these events with information theory. Our results
show that thalamic spike trains operate as two multiplexed channels. One
channel, which occupies a low frequency band (<30 Hz), is encoded by average
firing rate with respect to the stimulus and carries information about local
changes in the image over time. The other operates in the gamma frequency band
(40-80 Hz) and is encoded by spike time relative to the retinal oscillations.
Because these oscillations involve extensive areas of the retina, it is likely
that the second channel transmits information about global features of the
visual scene. At times, the second channel conveyed even more information than
the first.Comment: 21 pages, 10 figures, submitted to Frontiers in Systems Neuroscienc
Attosecond Precision Multi-km Laser-Microwave Network
Synchronous laser-microwave networks delivering attosecond timing precision
are highly desirable in many advanced applications, such as geodesy,
very-long-baseline interferometry, high-precision navigation and
multi-telescope arrays. In particular, rapidly expanding photon science
facilities like X-ray free-electron lasers and intense laser beamlines require
system-wide attosecond-level synchronization of dozens of optical and microwave
signals up to kilometer distances. Once equipped with such precision, these
facilities will initiate radically new science by shedding light on molecular
and atomic processes happening on the attosecond timescale, such as
intramolecular charge transfer, Auger processes and their impact on X-ray
imaging. Here, we present for the first time a complete synchronous
laser-microwave network with attosecond precision, which is achieved through
new metrological devices and careful balancing of fiber nonlinearities and
fundamental noise contributions. We demonstrate timing stabilization of a
4.7-km fiber network and remote optical-optical synchronization across a 3.5-km
fiber link with an overall timing jitter of 580 and 680 attoseconds RMS,
respectively, for over 40 hours. Ultimately we realize a complete
laser-microwave network with 950-attosecond timing jitter for 18 hours. This
work can enable next-generation attosecond photon-science facilities to
revolutionize many research fields from structural biology to material science
and chemistry to fundamental physics.Comment: 42 pages, 13 figure
An analytical model for the celestial distribution of polarized light, accounting for polarization singularities, wavelength and atmospheric turbidity
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