The association of up-regulation of FGF3 and hepatocellular carcinoma metastasis and recurrence

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Visualised inspection system for monitoring environmental anomalies during daily operation and maintenance

PurposeVisual inspection and human judgement form the cornerstone of daily operations and maintenance (O&M) services activities carried out by facility managers nowadays. Recent advances in technologies such as building information modelling (BIM), distributed sensor networks, augmented reality (AR) technologies and digital twins present an immense opportunity to radically improve the way daily O&M is conducted. This paper aims to describe the development of an AR-supported automated environmental anomaly detection and fault isolation method to assist facility managers in addressing problems that affect building occupants’ thermal comfort.Design/methodology/approachThe developed system focusses on the detection of environmental anomalies related to the thermal comfort of occupants within a building. The performance of three anomaly detection algorithms in terms of their ability to detect indoor temperature anomalies is compared. Based on the fault tree analysis (FTA), a decision-making tree is developed to assist facility management (FM) professionals in identifying corresponding failed assets according to the detected anomalous symptoms. The AR system facilitates easy maintenance by highlighting the failed assets hidden behind walls/ceilings on site to the maintenance personnel. The system can thus provide enhanced support to facility managers in their daily O&M activities such as inspection, recording, communication and verification.FindingsTaking the indoor temperature inspection as an example, the case study demonstrates that the O&M management process can be improved using the proposed AR-enhanced inspection system. Comparative analysis of different anomaly detection algorithms reveals that the binary segmentation-based change point detection is effective and efficient in identifying temperature anomalies. The decision-making tree supported by FTA helps formalise the linkage between temperature issues and the corresponding failed assets. Finally, the AR-based model enhanced the maintenance process by visualising and highlighting the hidden failed assets to the maintenance personnel on site.Originality/valueThe originality lies in bringing together the advances in augmented reality, digital twins and data-driven decision-making to support the daily O&M management activities. In particular, the paper presents a novel binary segmentation-based change point detection for identifying temperature anomalous symptoms, a decision-making tree for matching the symptoms to the failed assets, and an AR system for visualising those assets with related information.EPSRC, Innovate U

Does historical data still count? Exploring the applicability of smart building applications in the post-pandemic period

The emergence of COVID-19 pandemic is causing tremendous impact on our daily lives, including the way people interact with buildings. Leveraging the advances in machine learning and other supporting digital technologies, recent attempts have been sought to establish exciting smart building applications that facilitates better facility management and higher energy efficiency. However, relying on the historical data collected prior to the pandemic, the resulting smart building applications are not necessarily effective under the current ever-changing situation due to the drifts of data distribution. This paper investigates the bidirectional interaction between human and buildings that leads to dramatic change of building performance data distributions post-pandemic, and evaluates the applicability of typical facility management and energy management applications against these changes. According to the evaluation, this paper recommends three mitigation measures to rescue the applications and embedded machine learning algorithms from the data inconsistency issue in the post-pandemic era. Among these measures, incorporating occupancy and behavioural parameters as independent variables in machine learning algorithms is highlighted. Taking a Bayesian perspective, the value of data is exploited, historical or recent, pre- and post-pandemic, under a people-focused view

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells

The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined. In this study, we found that rifampicin, an agonist of human PXR, induced lipid accumulation in HepG2 cells. Lipid analysis showed the total cholesterol level increased. However, the free cholesterol and triglyceride levels were not changed. Treatment of HepG2 cells with rifampicin induced the expression of the free fatty acid transporter CD36 and ABCG1, as well as several lipogenic enzymes, including stearoyl-CoA desaturase-1 (SCD1), long chain free fatty acid elongase (FAE), and lecithin-cholesterol acyltransferase (LCAT), while the expression of acyl:cholesterol acetyltransferase(ACAT1) was not affected. Moreover, in PXR over-expressing HepG2 cells (HepG2-PXR), the SCD1 expression was significantly higher than in HepG2-Vector cells, even in the absence of rifampicin. Down-regulation of PXR by shRNA abolished the rifampicin-induced SCD1 gene expression in HepG2 cells. Promoter analysis showed that the human SCD1 gene promoter is activated by PXR and a novel DR-7 type PXR response element (PXRE) response element was located at -338 bp of the SCD1 gene promoter. Taken together, these results indicated that PXR activation promoted lipid synthesis in HepG2 cells and SCD1 is a novel PXR target gene. © 2013 Zhang et al

CAR-Net: Clairvoyant Attentive Recurrent Network

We present an interpretable framework for path prediction that leverages dependencies between agents' behaviors and their spatial navigation environment. We exploit two sources of information: the past motion trajectory of the agent of interest and a wide top-view image of the navigation scene. We propose a Clairvoyant Attentive Recurrent Network (CAR-Net) that learns where to look in a large image of the scene when solving the path prediction task. Our method can attend to any area, or combination of areas, within the raw image (e.g., road intersections) when predicting the trajectory of the agent. This allows us to visualize fine-grained semantic elements of navigation scenes that influence the prediction of trajectories. To study the impact of space on agents' trajectories, we build a new dataset made of top-view images of hundreds of scenes (Formula One racing tracks) where agents' behaviors are heavily influenced by known areas in the images (e.g., upcoming turns). CAR-Net successfully attends to these salient regions. Additionally, CAR-Net reaches state-of-the-art accuracy on the standard trajectory forecasting benchmark, Stanford Drone Dataset (SDD). Finally, we show CAR-Net's ability to generalize to unseen scenes.Comment: The 2nd and 3rd authors contributed equall

The association of cytoplasmic overexpression of cyclin d1 and tumor metastasis in Hepatocellular Carcinoma

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Heterogenous expression of beta-catenin, p16, e-cadherin, and c-myc in multi-stage colorectal carcinogenesis detected by tissue microarray

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Modeling, Oscillation Analysis and Distributed Stabilization Control of Autonomous PV-based Microgrids

Driven by rising energy demand and the goal of carbon neutrality, renewable energy generations (REGs), especially photovoltaic (PV) generations, are widely used in the urban power energy systems. While the intelligent control of microgrids (MG) brings economic and efficient operation, its potential stability problem cannot be ignored. To date, most of the research on modeling, analyzing and enhancing the stability of MG usually assume the DC-link as an ideal voltage source. However, this practice of ignoring the dynamics of DC-link may omit the latent oscillation phenomena of autonomous PV-based MG. First, this paper establishes a complete dynamic model of autonomous PV-based MG including PV panels and DC-link. Different from previous conclusions of idealizing DC-link dynamics, participation factor analysis finds the potential impact of DC-link dynamics on system dynamic performance, and different influence factors including critical control parameters and non-linear V-I output characteristic of PV array are considered to further reveal oscillation mechanisms. Second, based on the average consensus algorithm, a distributed stabilization controller with strong robustness is proposed to enhance stability of the PV-based MG, which does not affect the steady-state performance of the system. Finally, the correctness of all theoretical analysis and the effectiveness of the proposed controller are verified by time domain simulation and hardware-in-loop tests.10.13039/501100001809-National Natural Science Foundation of China (Grant Number: 51907031