116 research outputs found
Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma
<p>Abstract</p> <p>Background</p> <p>Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed and correlates with poor prognosis in many cancers. However, the clinical implication of H3K27me3 in human malignancies has not been well established. We wished to ascertain whether a correlation exists between the expression of H3K27me3 and clinical outcome in a group of patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT).</p> <p>Methods</p> <p>The method of immunohistochemistry (IHC) was utilized to examine the protein expression of H3K27me3 in 98 pretreatment biopsy specimens of ESCC and in 30 samples of normal esophageal mucosa. The clinical/prognostic significance of H3K27me3 expression was statistically analyzed.</p> <p>Results</p> <p>The expression frequency and expression levels of H3K27me3 were significantly higher in ESCCs than in normal tissues. There was a positive correlation between H3K27me3 expression and WHO grade (<it>P </it>= 0.016), tumor size (<it>P </it>= 0.019), T status (<it>P </it>= 0.024), locoregional progression (<it>P </it>= 0.009) and EZH2 expression (<it>P </it>= 0.036). High H3K27me3 expression was associated with poor locoregional progression-free survival (LPFS) (<it>P </it>= 0.010) in ESCC. Further analysis demonstrated that H3K27me3 could stratify patient outcome in T2-3 (<it>P </it>= 0.048), N0 (<it>P </it>= 0.005) and M0 (<it>P </it>= 0.018) stages as well as in CRT effective group (<it>P </it>= 0.022).</p> <p>Conclusions</p> <p>Our data suggests that H3K27me3 expression examined by IHC might be useful for stratifying LPFS for different subsets of ESCC patients treated with definitive CRT.</p
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas
The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma
Study of the doubly Cabibbo-suppressed decays and
Based on 7.33 fb of collision data collected at
center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector,
the experimental studies of the doubly Cabibbo-suppressed decays and are reported. We determine the
absolute branching fraction of to be
() . No
significant signal of is observed and the upper
limit on its decay branching fraction at 90\% confidence level is set to be
.Comment: 10 pages, 4 figures, 4 table
Observation of the Singly Cabibbo-Suppressed Decay
The singly Cabibbo-suppressed decay is observed for the first time with a statistical
significance of by using 4.5 fb of collision data
collected at center-of-mass energies between 4.600 and 4.699 GeV with the
BESIII detector at BEPCII. The absolute branching fraction of
is measured to be in a model-independent approach. This is
the first observation of a Cabibbo-suppressed decay involving
in the final state. The ratio of branching fractions between
and the Cabibbo-favored decay
is calculated to be , where with the
Cabibbo mixing angle. This ratio significantly deviates from and
provides important information for the understanding of nonfactorization
contributions in decays.Comment: 8 pages, 2 figure
Updated measurements of the M1 transition with
Based on a data sample of events
collected with the BESIII detector at the BEPCII collider, the M1 transition
with is
studied, where is or
. The mass and width of the are
measured to be MeV/
and MeV, respectively. The
product branching fraction is determined to be . Using , we obtain the branching fraction of the
radiative transition to be , where the third uncertainty is due to the quoted
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NEW DEVELOPMENT OF OPTIMUM GROUP SYNCHRONIZATION CODES
International Telemetering Conference Proceedings / October 29-November 02, 1990 / Riviera Hotel and Convention Center, Las Vegas, NevadaIn this paper, twenty-four optimum group synchronization codes (N=31 to 54) for PCM telemetry systems are presented. These optimum codes are the newest development at the category of optimum group synchronization codes up to now in the world.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection
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NEW DEVELOPMENT OF OPTIMUM GROUP SYNCHRONIZATION CODES (N=31 TO 42) FOR TELEMETRY SYSTEMS
International Telemetering Conference Proceedings / October 30-November 02, 1989 / Town & Country Hotel & Convention Center, San Diego, CaliforniaIn this paper, twelve optimum group synchronization codes (n=31 to 42) for PCM telemetry systems are presented. They are the newest achievements up to now.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection
Asymmetric Synthesis and Absolute Configuration Assignment of a New Type of Bedaquiline Analogue
Bedaquiline is the first FDA-approved new chemical entity to fight multidrug-resistant tuberculosis in the last forty years. Our group replaced the quinoline ring with a naphthalene ring, leading to a new type of triarylbutanol skeleton. An asymmetric synthetic route was established for our bedaquiline analogues, and the goal of assigning their absolute configurations was achieved by comparison of experimental and calculated electronic circular dichroism spectra, and was confirmed by the combined use of circular dichroism and NMR spectroscopy
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