26 research outputs found
Angle dependent field-driven reorientation transitions in uniaxial antiferromagnet MnBiTe single crystal
MnBiTe, a two-dimensional magnetic topological insulator with a
uniaxial antiferromagnetic structure, is an ideal platform to realize quantum
anomalous Hall effect. However, the strength of magnetic interactions is not
clear yet. We performed systematic studies on the magnetization and angle
dependent magnetotransport of MnBiTe single crystal. The results show
that the direction of the magnetic field has significant effects on the
critical field values and magnetic structure of this compound, which leads to
different magnetotransport behaviors. The field-driven reorientation
transitions can be utilized to estimate the AFM interlayer exchange interaction
coupling and uniaxial magnetic anisotropy D. The obtained Hamiltonian can well
explain the experimental data by Monte Carlo simulations. Our comprehensive
studies on the field-driven magnetic transitions phenomenon in MnBiTe
provide a general approach for other topological systems with
antiferromagnetism.Comment: 6 figure
Community physicians’ knowledge of secondary prevention after ischemic stroke: a questionnaire survey in Shanxi Province, China
Development of a skeletal oxidation mechanism for Fischer–Tropsch diesel surrogate based on decoupling method and particle swarm optimization
Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China
miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC
Abstract Background Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA disorders are involved in the pathogenesis of human diseases, such as cancer. However, the effects of miRNA dysregulation on tumour stemness and drug resistance have not been fully elucidated. miR-181b has been reported to be a tumour suppressor miRNA and is associated with drug-resistant non-small cell lung cancer. Methods Cancer stem cell (CSC)-like properties were tested by a cell proliferation assay and flow cytometry; miR-181b expression was measured by real-time PCR; and Notch2 and related proteins were detected by Western blotting and immunohistochemistry. A mouse xenograft model was also established. Results In this study, we found that ectopic miR-181b expression suppressed cancer stem cell properties and enhanced sensitivity to cisplatin (DDP) treatment by directly targeting Notch2. miR-181b could inactivate the Notch2/Hes1 signalling pathway. In addition, tumours from nude mice treated with miR-181b were significantly smaller than tumours from mice treated with control agomir. Decreased miR-181b expression and increased Notch2 expression were observed to have a significant relationship with overall survival (OS) and CSC-like properties in non-small cell lung cancer (NSCLC) patients. Conclusions This study elucidates an important role of miR-181b in the regulation of CSC-like properties, suggesting a potential therapeutic target for overcoming drug resistance in NSCLC