A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

AbstractTumor necrosis factor (TNFα) receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-κB and the kinase, JNK. While activation of caspase 8 is required for TNFα-induced apoptosis, and induction of NF-κB inhibits cell death, the precise function of JNK activation in TNFα signaling is not clearly understood. Here, we report that TNFα-mediated caspase 8 cleavage and apoptosis require a sequential pathway involving JNK, Bid, and Smac/DIABLO. Activation of JNK induces caspase 8-independent cleavage of Bid at a distinct site to generate the Bid cleavage product jBid. Translocation of jBid to mitochondria leads to preferential release of Smac/DIABLO, but not cytochrome c. The released Smac/DIABLO then disrupts the TRAF2-cIAP1 complex. We propose that the JNK pathway described here is required to relieve the inhibition imposed by TRAF2-cIAP1 on caspase 8 activation and induction of apoptosis. Further, our findings define a mechanism for crosstalk between intrinsic and extrinsic cell death pathways

Simulated identification on dynamic characteristics of large heavy-load bearing

It’s difficult to test repeatedly for large heavy-load bearings (LHLBs) with full-scale and real load due to complexity and costliness, so simulated identification on dynamic characteristics of 1750 MW nuclear generator bearing with diameter 800 mm and specific pressure 3.3 MPa is provided in this paper. The identification model of bearing dynamic characteristic is established, the calculating method of positive and negative dynamic problems is provided, and effects of signal disturbances on identification precision are analyzed. The results show that the LHLBs’ permitted displacement disturbance should not be over 5 μm and the permitted ratio of dynamic load and static load is about 1 %-2 %, which is different from common knowledge of 15 %-20 % for small light-load bearings. If identification error of the main stiffness and main damping coefficients is less than 5 %, the amplitude of periodical disturbance of the dynamic load and displacement signals should be less than 5 %. If identification error of the main damping coefficients is less than 10 %, the phase of these two signals should be less than 1°. The roundness error and rotation error of the large shaft should be eliminated

Energy-efficient domain wall motion governed by the interplay of helicity-dependent optical effect and spin-orbit torque

Spin-orbit torque provides a powerful means of manipulating domain walls along magnetic wires. However, the current density required for domain wall motion is still too high to realize low power devices. Here we experimentally demonstrate helicity-dependent domain wall motion by combining synchronized femtosecond laser pulses and short current pulses in Co/Ni/Co ultra-thin film wires with perpendicular magnetization. Domain wall can remain pinned under one laser circular helicity while depinned by the opposite circular helicity. Thanks to the all-optical helicity-dependent effect, the threshold current density due to spin-orbit torque can be reduced by more than 50%. Based on this joint effect combining spin-orbit torque and helicity-dependent laser pulses, an optoelectronic logic-in-memory device has been experimentally demonstrated. This work enables a new class of low power spintronic-photonic devices beyond the conventional approach of all-optical switching or all-current switching for data storage.Comment: 21 pages, 5 figure

Multi-Granularity Click Confidence Learning via Self-Distillation in Recommendation

Recommendation systems rely on historical clicks to learn user interests and provide appropriate items. However, current studies tend to treat clicks equally, which may ignore the assorted intensities of user interests in different clicks. In this paper, we aim to achieve multi-granularity Click confidence Learning via Self-Distillation in recommendation (CLSD). Due to the lack of supervised signals in click confidence, we first apply self-supervised learning to obtain click confidence scores via a global self-distillation method. After that, we define a local confidence function to adapt confidence scores at the user group level, since the confidence distributions can be varied among user groups. With the combination of multi-granularity confidence learning, we can distinguish the quality of clicks and model user interests more accurately without involving extra data and model structures. The significant improvements over different backbones on industrial offline and online experiments in a real-world recommender system prove the effectiveness of our model. Recently, CLSD has been deployed on a large-scale recommender system, affecting over 400 million users

Domain-wall motion induced by spin transfer torque delivered by helicity-dependent femtosecond laser

In magnetic wires with perpendicular anisotropy, moving domain with only current or only circularly polarized light requires a high power. Here, we propose to reduce it by using both short current pulses and femtosecond laser pulses simultaneously. The wires were made out of perpendicularly magnetized film of Pt/Co/Ni/Co/Pt. The displacement of the domain wall is found to be dependent on the laser helicity. Based on a quantitative analysis of the current-induced domain wall motion, the spin orbit torque contribution can be neglected when compared to the spin transfer torque contribution. The effective field of the spin transfer torque is extracted from the pulsed field domain wall measurements. Finally, our result can be described using the Fatuzzo-Labrune model and considering the effective field due to the polarized laser beam, the effective field due to spin transfer torque, and the Gaussian temperature distribution of the laser spot.Comment: 14 pages, 4 figure