216 research outputs found
Deep Learning-Enabled Semantic Communication Systems with Task-Unaware Transmitter and Dynamic Data
Existing deep learning-enabled semantic communication systems often rely on
shared background knowledge between the transmitter and receiver that includes
empirical data and their associated semantic information. In practice, the
semantic information is defined by the pragmatic task of the receiver and
cannot be known to the transmitter. The actual observable data at the
transmitter can also have non-identical distribution with the empirical data in
the shared background knowledge library. To address these practical issues,
this paper proposes a new neural network-based semantic communication system
for image transmission, where the task is unaware at the transmitter and the
data environment is dynamic. The system consists of two main parts, namely the
semantic coding (SC) network and the data adaptation (DA) network. The SC
network learns how to extract and transmit the semantic information using a
receiver-leading training process. By using the domain adaptation technique
from transfer learning, the DA network learns how to convert the data observed
into a similar form of the empirical data that the SC network can process
without retraining. Numerical experiments show that the proposed method can be
adaptive to observable datasets while keeping high performance in terms of both
data recovery and task execution
Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma
BACKGROUND: It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role in PI3K/AKT pathway. However, the copy number variations (CNVs) of PI3K subunits on gene level remain unknown in DLBCL. Therefore, the aim of the study is to investigate the CNV of PI3K subunits and their relationship with clinicopathological features exploring the possible mechanism underlying of PI3K activation in DLBCL. METHODS: CNV of 12 genes in the PI3K/AKT pathway was detected by NanoString nCounter in 60 de novo DLBCLs and 10 reactive hyperplasia specimens as controls. Meanwhile, immunohistochemistry (IHC) was performed to examine the expression of p110Ī±, p110Ī², p110Ī³, p110Ī“, and pAKT on DLBCL tissue microarrays. RESULTS: All PI3K and AKT subunits, except for PIK3R1, had various CNVs in the form of copy number amplifications and copy number losses. Their rates were in the range of 8.3ā20.0%. Of them PIK3CA and PIK3CB gene CNVs were significantly associated with decreased overall survival (P = 0.029 and P = 0.019, respectively). IHC showed that the frequency of strong positive expression of p110Ī±, p110Ī², p110Ī³, and p110Ī“ were 26.7%, 25.0%, 18.3%, and 25.0% respectively, and they were found to be associated with decreased survival (P = 0.022, P = 0.015, P = 0.015, and P = 0.008, respectively). Expression of p110Ī± was not only significantly associated with CNVs of PIK3CA (P = 0.002) but also positively correlated with strong positive expression of pAKT (P = 0.026). CONCLUSIONS: CNV of PIK3CA is highly associated with aberrant p110Ī± protein expression and subsequent activation of PI3K/AKT pathway. CNVs of PIK3CA and PIK3CB, and aberrant protein expression of p110 isoforms are of great important value for predicting inferior prognosis in DLBCL. Frequent CNVs of PI3K/AKT subunits may play an important role in the tumorigenesis of DLBCL
Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas.
MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy, and high risk of refractory disease. MYC plays a central role by coordinating hyperactive protein synthesis with upregulated transcription in order to support rapid proliferation of tumor cells. Translation initiation inhibitor rocaglates have been identified as the most potent drugs in MYC-driven lymphomas as they efficiently inhibit MYC expression and tumor cell viability. We found that this class of compounds can overcome eIF4A abundance by stabilizing target mRNA-eIF4A interaction that directly prevents translation. Proteome-wide quantification demonstrated selective repression of multiple critical oncoproteins in addition to MYC in B-cell lymphoma including NEK2, MCL1, AURKA, PLK1, and several transcription factors that are generally considered undruggable. Finally, (-)-SDS-1-021, the most promising synthetic rocaglate, was confirmed to be highly potent as a single agent, and displayed significant synergy with the BCL2 inhibitor ABT199 in inhibiting tumor growth and survival in primary lymphoma cells in vitro and in patient-derived xenograft mouse models. Overall, our findings support the strategy of using rocaglates to target oncoprotein synthesis in MYC-driven lymphomas.P30 CA036727 - NCI NIH HHS; R24 GM111625 - NIGMS NIH HHS; R35 GM118173 - NIGMS NIH HHS; LB506 - Nebraska Department of Health and Human Services (Nebraska DHHS)Accepted manuscriptSupporting documentatio
Parental phubbing and mobile phone addiction among Chinese adolescents: a moderated mediation model
It has been reported that parental phubbing is a significant predictor of mobile phone addiction (MPA) among adolescents. However, the mechanisms underlying this association remain largely unclarified. On the basis of the social learning theories and ecological systems, this study assessed the mediating effect of deviant peer affiliation and the moderating effect of sensation seeking in the association between parental phubbing and MPA among Chinese adolescents. A total of 786 Chinese adolescents (mean ageā=ā13.17āyears, SD =ā1.35) completed the questionnaires anonymously about parental phubbing, MPA, deviant peer affiliation and sensation seeking. After controlling for study variables, deviant peer affiliation could partially mediate the association between parental phubbing and MPA among adolescents and this indirect path could be moderated by sensation seeking. Notably, the effect of deviant peer affiliation on MPA was more pronounced in adolescents with higher sensation seeking than in those with lower sensation seeking
Family function and adolescent altruistic behavior: the multiple mediating effects of self-affirmation and psychological resilience
IntroductionThe current study aimed to explore the relationship between family function and adolescent altruistic behavior, as well as the mediating effects of self-affirmation and psychological resilience in this relationship.MethodsA survey was conducted on 972 high school students in Guangdong Province using the Family APGAR, GHQSense of Adequacy, Chinese version of Connor-Davidson Resilience Scale, and Altruistic Behavior Scale.ResultsResults found that the score of psychological resilience of males was significantly higher than that of females, but the score of altruistic behavior was significantly lower than that of females. Family function had a positive predictive effect on altruistic behavior. Psychological resilience played a mediating role between family function and altruistic behavior. Self-affirmation and psychological resilience played chain mediating roles between family function and altruistic behavior.DiscussionThis study indicated that family care is crucial for the development of adolescent altruistic behavior, and that it can promote the development of altruistic behavior through the enhancement of self-affirmation and psychological resilience
The predictive value of revised diastolic dysfunction in outcomes of liver transplantation: A propensity score matching analysis
BackgroundDiastolic dysfunction (DD), one of the earliest signs of cirrhotic cardiomyopathy (CCM), is included in the revised 2019 CCM criteria. Nonetheless, relevant research regarding the effects of revised DD on post-liver transplantation (LT) outcomes remains limited.MethodsThis retrospective study enrolled patients who underwent LT for decompensated cirrhosis, from January 2018 to March 2021. Patients were divided into DD and non-DD groups. Clinical data were collected. Patients were followed up with, for at least 1 year post-LT; cardiovascular adverse events (AEs) and survival status were recorded. Risk factors were identified using 1:2 propensity score matching (PSM), after adjusting for confounding factors. The caliper value was set to 0.02.ResultsOf 231 patients, 153 were diagnosed with DD (male, 81.8%; mean age, 51.5āĀ±ā9.5 years). Nineteen patients with DD died within 1 year, post-LT. After PSM, 97 and 60 patients were diagnosed with and without DD, respectively. Patients with DD had longer intensive care unit (ICU) stays, higher perioperative cardiovascular AEs, and higher mortality rates than those without DD. In a multivariate analysis, interventricular septum (IVS), left atrial volume index (LAVI), and potassium levels were independent prognostic factors of perioperative cardiovascular AEs, while a decreased early diastolic mitral annular tissue velocity (eā), increased neutrophil-to-lymphocyte ratio (NLR) and tumor markers were predictors of mortality within 1 year post-LT after PSM (Pā<ā0.05).ConclusionCardiac DD may contribute to perioperative cardiovascular AEs and mortality post-LT. Clinicians should be aware of decompensated cirrhosis in patients with DD
Epitaxial growth of high quality thin films by pulsed laser deposition
Non-collinear antiferromagnet Weyl semimetal have attracted great
research interest recently. Although large anomalous Hall effect, anomalous
Nernst effect and magneto-optical effect have been observed in , most
studies are based on single crystals. So far, it is still challenging to grow
high quality epitaxial thin films with transport and optical
properties comparable to their single crystal counterparts. Here, we report the
structure, magneto-optical and transport properties of epitaxial thin
films fabricated by pulsed laser deposition (PLD). Highly oriented
(0001) and (110) epitaxial films are successfully
growth on single crystalline and MgO substrates. Large anomalous Hall
effect (AHE) up to =3.02 , and
longitudinal magneto-optical Kerr effect (LMOKE) with = 38.1 mdeg at
633 nm wavelength are measured at 300 K temperature, which are comparable to
single crystals. Our work demonstrates that high quality
epitaxial thin films can be fabricated by PLD, paving the way for future device
applications
Activation of MET signaling by HDAC6 offers a rationale for a novel ricolinostat and crizotinib combinatorial therapeutic strategy in diffuse large Bācell lymphoma
Some histone deacetylases (HDACs) promote tumor cell growth and panā or selective HDAC inhibitors are active in some cancers; however, the pivotal HDAC enzyme and its functions in human diffuse large Bācell lymphoma (DLBCL) remain largely unknown. Using NanoString nCounter assays, we profiled HDAC mRNA expression and identified HDAC6 as an upregulated HDAC family member in DLBCL tissue samples. We then found that HDAC6 plays an oncogenic role in DLBCL, as evidenced by its promotion of cell proliferation in vitro and tumor xenograft growth in vivo. Mechanistically, the interaction between HDAC6 and HR23B downregulated HR23B expression, thereby reducing the levels of casitas Bālineage lymphoma (cāCbl), an E3 ubiquitin ligase for hepatocyte growth factor receptor (MET), which resulted in the inhibition of MET ubiquitinationādependent degradation. In addition, enhanced HDAC6 expression and decreased HR23B expression were correlated with poor overall survival rates among patients with DLBCL. Taken together, these results establish an HDAC6āHR23BāMET axis and indicate that HDAC6 is a potent promoter of lymphomagenesis in DLBCL. Thus, a therapeutic strategy based on HDAC6 inhibitors in combination with MET inhibitors is promising. Copyright Ā© 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146400/1/path5108_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146400/2/path5108.pd
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