Reversible and Non-Competitive Inhibition of Cyclooxygenase by Indobufen for Efficient Antiplatelet Action and Relief of Gastrointestinal Irritation

Clinically, indobufen is widely used for the treatment of antiplatelet aggregation and anticoagulation. Prior studies have discovered that abnormal platelet function can be promptly restored to normal when the drug is stopped. Herein, through the study of the enzyme reaction kinetics, we demonstrated that the inhibitory effect of indobufen on cyclooxygenase-1 (COX-1) was reversible and non-competitive. Specifically, the cyclooxygenase inhibition experiment showed that the level of 6-keto-PGF1α in the gastric mucosa of the indobufen-treated groups was significantly higher than that of the aspirin group (###p 2 in and a better physiological state of the gastric mucosa. Moreover, the rat gastric ulcer index and mucosal section experiments further confirmed the relief of gastrointestinal irritation and the adverse reaction rate of the indobufen-treated group compared to those of the aspirin group. Furthermore, indobufen was verified to exert reversible inhibitory activity on the heme group of COX-1 and thus reversibly inhibit COX-1 activity. In general, compared with aspirin, the long-term oral administration of indobufen yields a lower risk of gastrointestinal symptoms, such as ulcers

Full-Coverage and k-Connectivity (k =14, 6) Three Dimensional Networks

Abstract—In this paper, we study the problem of constructing full-coverage three dimensional networks with multiple connectivity. We design a set of patterns for full coverage and two representative connectivity requirements, i.e. 14- and 6-connectivity. We prove their optimality under any ratio of the communication range over the sensing range among regular lattice deployment patterns. We also conduct a study on the proposed patterns under practical settings. To our knowledge, our work is the first one that provides deployment patterns with proven optimality that achieve both coverage and connectivity in three dimensional networks. I

Early Telychian (Silurian) marine siliciclastic red beds in the Eastern Yangtze Platform, South China: distribution pattern and controlling factors

The distribution pattern of early Telychian (turriculatus-crispus graptolite biozone) red beds in the Eastern Yangtze Platform of South China is reconstructed based on regional geologic data. The red beds are developed in three areas, which are separated by regions without red deposition. The distribution pattern indicates that the Cathaysian Oldland was the provenance of sediment rich in ferric oxides, which are essential for the formation of red beds. Silurian marine siliciclastic red beds, both in China and worldwide, tended to develop during times of relatively low sea level. Coeval hematitic oolites that formed far from the coast may record a change from reducing to oxidizing conditions in the ocean. Furthermore, it is likely that a fall in global sea level, a transition from reducing to oxidizing conditions in the ocean, and a cooling climate, all of which were closely related to the early Telychian Valgu Event, promoted the global development of marine red beds during this period.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Connected Coverage in Wireless Networks with Directional Antennas

Abstract—In this paper, we address a new unexplored problem- what are the optimal patterns to achieve connected coverage in wireless networks with directional antennas. As their name implies, directional antennas can focus their transmission energy in a certain direction. This feature leads to lower cross-interference and larger communication distance. It has been shown that with proper scheduling mechanisms, directional antennas may substantially improve networking performance in wireless networks. In this paper, we propose a set of optimal patterns to achieve full coverage and global connectivity under two different antenna models, i.e., the sector model and the knob model. We also introduce with detailed analysis several fundamental theorems and conjectures. Finally, we examine a more realistic physical model, where there might be strong interference, and both the sensing range and the communication range might be irregular. The results show that our designed patterns work well even in unstable and fickle physical environments. I

Pattern Mutation in Wireless Sensor Deployment

ohio-state.edu corresponding author Abstract—In this paper, we study the optimal deployment pattern problem in wireless sensor networks (WSNs). We propose a new set of patterns, particularly when sensors ’ communication range (rc) is relatively small compared with their sensing range (rs), and prove their optimality among regular patterns. In this study, we discover a surprising and interesting phenomenon— pattern mutation. This phenomenon contradicts the conjecture presented in a previous work that there exists a universal elemental pattern among optimal pattern evolution and that pattern evolution is continuous. For example, we find mutation happens among the patterns for full-coverage and 3-connectivity when rc/rs = 1.0459, among the patterns for full-coverage and 4-connectivity when rc/rs =1.3903, and among the patterns for full-coverage and 5-connectivity when rc/rs =1.0406. To the best of our knowledge, this is the first time that mutation in pattern evolution has been discovered. Also, our work further completes the exploration of optimal patterns in WSNs. I

The stochastic dynamical behaviors of the gene regulatory circuit in Bacillus subtilis

In recent years, the gene regulatory circuit in biological systems has attracted a considerable interest. In this paper, we consider the dynamical behaviors of the gene regulatory circuit in Bacillus subtilis, including deterministic system and stochastic system effected by colored noise. First of all, the global dynamical behaviors of the deterministic system are exhibited by numerical method. Moreover, we give an effective method to explore the stochastic response and bifurcation by means of the stochastic generalized cell mapping method. To satisfy the Markov nature, we transform the colored-noise system into the equivalent white-noise system. And the stochastic generalized cell mapping method can be used to obtain the dynamical behaviors of the stochastic system. We found that the system parameters and noise can induce the occurrence of the stochastic P-bifurcation in the stochastic system, which means that the conversion between competent state and vegetative state in Bacillus subtilis is possible. In addition, the effectiveness of the stochastic generalized cell mapping method is verified by Monte Carlo simulation