Thoughts on Jinan's Establishment of the National Central City of China's Yellow River Basin

The national central city is not a single existence, and it must be based on the national-level urban agglomeration. At the same time, it must have superior geographical advantages and rich natural resources as the basis for development. Urban agglomeration promotes national central cities; on the contrary, national central cities can also drive the common development of urban agglomerations. During the National People’s Congress and National Committee of the Chinese People’s Political Consultative Conference this year, Jinan Municipal Government proposed to create a national central city in the Yellow River Basin as the development goal. In this article, the measures taken by Jinan Municipal Government to create the national central city of the Yellow River Basin are put forward, and the impact of the surrounding urban agglomeration on the development of Jinan is pointed out. Meanwhile, the opportunities and challenges that Jinan will bring to the surrounding urban agglomeration by establishing the national central city are elaborated

A bibliometric analysis of myocardial ischemia/reperfusion injury from 2000 to 2023

BackgroundMyocardial ischemia/reperfusion injury (MIRI) refers to the more severe damage that occurs in the previously ischemic myocardium after a short-term interruption of myocardial blood supply followed by restoration of blood flow within a certain period of time. MIRI has become a major challenge affecting the therapeutic efficacy of cardiovascular surgery.MethodsA scientific literature search on MIRI-related papers published from 2000 to 2023 in the Web of Science Core Collection database was conducted. VOSviewer was used for bibliometric analysis to understand the scientific development and research hotspots in this field.ResultsA total of 5,595 papers from 81 countries/regions, 3,840 research institutions, and 26,202 authors were included. China published the most papers, but the United States had the most significant influence. Harvard University was the leading research institution, and influential authors included Lefer David J., Hausenloy Derek J., Yellon Derek M., and others. All keywords can be divided into four different directions: risk factors, poor prognosis, mechanisms and cardioprotection.ConclusionResearch on MIRI is flourishing. It is necessary to conduct an in-depth investigation of the interaction between different mechanisms and multi-target therapy will be the focus and hotspot of MIRI research in the future

Effects of common carp (Cyprinus carpio) on water quality in aquatic ecosystems dominated by submerged plants: a mesocosm study

Common carp (Cyprinus carpio) have been introduced into aquatic systems across the world, where their benthivorous feeding behavior has resulted in serious water quality problems. A 12-week mesocosm experiment was set up to test the hypotheses that common carp increase water column nutrient levels and decrease water clarity in aquatic ecosystems dominated by submerged plants. Further, we tested whether the effect of common carp on macrophytes depended on the species of plants. Relative to the controls, the presence of carp decreased water clarity by increasing total suspended solids (TSS) and light attenuation. However, levels of total nitrogen (TN) and total phosphorus (TP) in the water column were reduced. No significant change in phytoplankton biomass (measured as chlorophyll a) and the biomass of Hydrilla verticillata was observed between common carp treatment mesocosms and controls, but the common carp did reduce the biomass of the submerged macrophyte Vallisneria denseserrulata. We conclude that removal of common carp is likely to improve water clarity in aquatic ecosystems dominated by submerged plants primarily by decreasing TSS and that the effect of common carp on macrophytes is stronger for the meadow forming Vallisneria than for the canopy forming Hydrilla

Xenotime-type high-entropy (Dy1/7Ho1/7Er1/7Tm1/7Yb1/7Lu1/7Y1/7)PO4: A promising thermal/environmental barrier coating material for SiCf/SiC ceramic matrix composites

Rare-earth phosphates (REPO4) are regarded as one of the promising thermal/environmental barrier coating (T/EBC) materials for SiCf/SiC ceramic matrix composites (SiC-CMCs) owing to their excellent resistance to water vapor and CaO–MgO–Al2O3–SiO2 (CMAS). Nevertheless, a relatively high thermal conductivity (κ) of the REPO4 becomes the bottleneck for their practical applications. In this work, novel xenotime-type high-entropy (Dy1/7Ho1/7Er1/7Tm1/7Yb1/7Lu1/7Y1/7)PO4 (HE (7RE1/7)PO4) has been designed and synthesized for the first time to solve this issue. HE (7RE1/7)PO4 with a homogeneous rare-earth element distribution exhibits high thermal stability up to 1750 ℃ and good chemical compatibility with SiO2 up to 1400 ℃. In addition, the thermal expansion coefficient (TEC) of HE (7RE1/7)PO4 (5.96×10−6 ℃−1 from room temperature (RT) to 900 ℃) is close to that of the SiC-CMCs. What is more, the thermal conductivities of HE (7RE1/7)PO4 (from 4.38 W·m−1·K−1 at 100 ℃ to 2.25 W·m−1·K−1 at 1300 ℃) are significantly decreased compared to those of single-component REPO4 with the minimum value ranging from 9.90 to 4.76 W·m−1·K−1. These results suggest that HE (7RE1/7)PO4 has the potential to be applied as the T/EBC materials for the SiC-CMCs in the future

Research Progress in the Formation of Quality of Dry-Aged Beef and Approaches for Its Added Value

Dry aging is an effective method to improve the quality and value of meat. Meat quality characteristics such as tenderness and flavor can be significantly improved through a series of biochemical reactions. In recent years, dry-aged beef has gained huge popularity among consumers and research attention due to its unique flavor. However, there are some problems with the dry-aged beef industry, such as large quality differences, high losses during maturation, and high production costs. This article systematically summarizes quality characteristics of dry-aged beef, including flavor, tenderness, safety, color and water-holding capacity (WHC). The mechanism of formation of its characteristic flavor is briefly described. The effects of different dry-aging conditions on beef quality are summarized. New dry aging technologies and value-added ways to reuse the crust are introduced. This article will hopefully provide theoretical guidance for the standardized, efficient and high-value development of the dry-aged beef industry

Effect of arotinolol on chronic heart failure: A systematic review and meta-analysis of randomized controlled trials

BackgroundHeart failure is the end stage of all cardiovascular diseases, which brings a heavy burden to the global health network. Arotinolol, as a new type of β Receptor blocker, has a good antihypertensive effect. Many clinical trials have observed the clinical efficacy of arotinolol in the treatment of essential hypertension. However, so far, there has been no systematic evaluation on the efficacy and safety of arotinolol in the treatment of chronic heart failure.ObjectiveThe purpose of this review was to systematically evaluate the clinical efficacy of arotinolol in patients with chronic heart failure.MethodsRandomized controlled trials (RCTs) of arotinolol in the treatment of chronic heart failure were retrieved from seven databases according to the Cochrane manual, including CNKI (China National Knowledge Infrastructure), Wan fang database, VIP database, PubMed, Sinomed, EMBASE, and the Cochrane Library databases. The main outcomes were the effective rate, left ventricular ejection fraction (LVEF), blood pressure, heart rate, cardiac index, stroke volume (SV), brain natriuretic peptide (BNP), hypersensitive C-reactive protein (Hs-CRP), left ventricular end diastolic volume (LVEDV), left ventricular end diastolic diameter (LVEDD), and adverse events (AEs).ResultsA total of 17 trials met the qualification criteria, which included 1,717 patients with heart failure. Most trials had uncertain risks in terms of random sequence generation, allocation hiding, patient loss, and result evaluation. Meta analysis showed that arotinolol significantly improved the treatment efficiency of patients with heart failure (standardized mean difference (SMD) = 4.07, 95% confidence interval (CI) [2.89, 5.72], p = 0.00, I2 = 0), LVEF (SMD = 1.59, 95% CI [0.99, 2.19], p = 0.000 0, I2 = 95.8%), cardiac index (SMD = 0.32, 95% CI [0.11, 0.53], p = 0.03), I2 = 0), SV (SMD = 2.00, 95% CI [1.57, 2.34], p = 0.000, I2 = 64.2%), lower BNP (SMD = −0.804, 95% CI [−0.97, −0.64], p = 0.000, I2 = 94.4%), and LVEDV (SMD = −0.25, 95% CI [−0.45, −0.05], p = 0.015, I2 = 0). There was no statistical significance for blood pressure (SMDsystolic pressure = −0.09, 95% CI [−0.69, 0.51], p = 0.775, I2systolic pressure = 90.2%; SMDdiastolic pressure = −0.16, 95% CI [−0.79, 0.48], P = 0.632, I2diastolic pressure = 91.2%), heart rate (SMD = −0.12, 95% CI [−1.00, 0.75], P = 0.787, I2 = 96.1%), Hs-CRP (SMD = −1.52, 95% CI [−3.43, 0.40], P = 0.121, I2 = 98.3%), and LVEDD (SMD = −0.07, 95% CI [−0.90, 0.76], P = 0.870, I2 = 96.5%).ConclusionArotinolol can safely and effectively improve the effective rate of patients with chronic heart failure, increase LVEF, increase CI and SV, and reduce BNP and LVEDV. However, because of the low overall quality of the included randomized controlled trials, these findings need to be considered carefully. More high-quality randomized controlled trials are needed for further verification, to provide a more scientific basis for the safety and effectiveness of arotinolol in the clinical treatment of heart failure.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=371214], identifier [CRD:420223371214]

Wall enhancement predictive of abnormal hemodynamics and ischemia in vertebrobasilar non-saccular aneurysms: a pilot study

ObjectiveTo analyze how wall enhancement affects hemodynamics and cerebral ischemic risk factors in vertebrobasilar non-saccular intracranial aneurysms (VBNIAs).Materials and methodsTen consecutive non-saccular aneurysms were collected, including three transitional vertebrobasilar dolichoectasia (TVBD). A wall enhancement model was quantitatively constructed to analyze how wall enhancement interacts with hemodynamics and cerebral ischemic factors.ResultsEnhanced area revealed low wall shear stress (WSS) and wall shear stress gradient (WSSG), with high oscillatory shear index (OSI), relative residence time (RRT), and gradient oscillatory number (GON) while the vortex and slow flow region in fusiform aneurysms are similar to TVBD fusiform aneurysms. With low OSI, high RRT and similar GON in the dilated segment, the enhanced area still manifests low WSS and WSSG in the slow flow area with no vortex. In fusiform aneurysms, wall enhancement was negatively correlated with WSS (except for case 71, all p values  < 0.05, r = −0.52 ~ −0.95), while wall enhancement was positively correlated with OSI (except for case 5, all p values < 0.05, r = 0.50 ~ 0.83). For the 10 fusiform aneurysms, wall enhancement is significantly positively correlated with OSI (p = 0.0002, r = 0.75) and slightly negatively correlated with WSS (p = 0.196, r = −0.30) throughout the dataset. Aneurysm length, width, low wall shear stress area (LSA), high OSI, low flow volume (LFV), RRT, and high aneurysm-to-pituitary stalk contrast ratio (CRstalk) area plus proportion may be predictive of cerebral ischemia.ConclusionA wall enhancement quantitative model was established for vertebrobasilar non-saccular aneurysms. Low WSS was negatively correlated with wall enhancement, while high OSI was positively correlated with wall enhancement. Fusiform aneurysm hemodynamics in TVBD are similar to simple fusiform aneurysms. Cerebral ischemia risk appears to be correlated with large size, high OSI, LSA, and RRT, LFV, and wall enhancement

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

Alternative splicing is prevalent in the mammalian brain. To interrogate the functional role of alternative splicing in neural development, we analyzed purified neural progenitor cells (NPCs) and neurons from developing cerebral cortices, revealing hundreds of differentially spliced exons that preferentially alter key protein domains—especially in cytoskeletal proteins—and can harbor disease-causing mutations. We show that Ptbp1 and Rbfox proteins antagonistically govern the NPC-to-neuron transition by regulating neuron-specific exons. Whereas Ptbp1 maintains apical progenitors partly through suppressing a poison exon of Flna in NPCs, Rbfox proteins promote neuronal differentiation by switching Ninein from a centrosomal splice form in NPCs to a non-centrosomal isoform in neurons. We further uncover an intronic human mutation within a PTBP1-binding site that disrupts normal skipping of the FLNA poison exon in NPCs and causes a brain-specific malformation. Our study indicates that dynamic control of alternative splicing governs cell fate in cerebral cortical development. Keywords: filamin A; Ninein; Ptbp1; Rbfox; microcephaly; periventricular nodular heterotopia; mother centrioleNational Cancer Institute (U.S.) (Grant P01-CA42063

Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer

Reprogramming of fatty acid metabolism promotes cell growth and metastasis through a variety of processes that stimulate signaling molecules, energy storage, and membrane biosynthesis in endometrial cancer. Oleic acid is one of the most important monounsaturated fatty acids in the human body, which appears to have both pro- and anti-tumorigenic activities in various pre-clinical models. In this study, we evaluated the potential anti-tumor effects of oleic acid in endometrial cancer cells and the LKB1fl/flp53fl/fl mouse model of endometrial cancer. Oleic acid increased lipogenesis, inhibited cell proliferation, caused cell cycle G1 arrest, induced cellular stress and apoptosis, and suppressed invasion in endometrial cancer cells. Targeting of diacylglycerol acyltransferases 1 and 2 effectively increased the cytotoxicity of oleic acid. Moreover, oleic acid significantly increased the expression of wild-type PTEN, and knockdown of PTEN by shRNA partially reversed the anti-proliferative and anti-invasive effects of oleic acid. Inhibition of the AKT/mTOR pathway by ipatasertib effectively increased the anti-tumor activity of oleic acid in endometrial cancer cells. Oleic acid treatment (10 mg/kg, daily, oral) for four weeks significantly inhibited tumor growth by 52.1% in the LKB1fl/flp53fl/fl mice. Our findings demonstrated that oleic acid exhibited anti-tumorigenic activities, dependent on the PTEN/AKT/mTOR signaling pathway, in endometrial cancer