Bis(3,5-dimethyl­pyrazole)[N-salicyl­idene-β-alaninato(2–)]copper(II) dihydrate

In the title compound, [Cu(C10H10NO3)(C5H8N2)2]·2H2O, the CuII atom is coordinated by three N atoms and two O atoms in a distorted square-pyramidal geometry. The crystal packing is stabilized by inter­molecular O—H⋯O and N—H⋯O hydrogen bonds

Modeling blue stragglers in young clusters

In this paper, a grid of the binary evolution models are calculated for the study of blue straggler (BS) population in intermediate age ($\log Age$=7.85-8.95) star clusters. The BS formation via mass transfer and merging is studied systematically using our models. Both Case A and B close binary evolutionary tracks are calculated in a large range of parameters. The results show that BSs formed via Case B are generally bluer and even more luminous than those produced by Case A. Furthermore, the larger range in orbital separations of Case B models provide a probability of producing more BSs than Case A. Based on the grid of models, several Monte-Carlo simulations of BS populations in the clusters in the age range are carried out. The results show that BSs formed via different channels populate different areas in color magnitude diagram(CMD). The locations of BSs in CMD for a number of clusters are compared to our simulations as well. In order to investigate the influence of mass transfer efficiency in the models and simulations, a set of models are also calculated by implementing a constant mass transfer efficiency, $\beta$=0.5 during Roche lobe overflow (Case A binary evolution excluded). The result shows BSs can be formed via mass transfer at any given age in both cases. However, the distributions of the BS populations on CMD are different.Comment: 18 pages, 5 figures, 2 table

Physical exercise frequency and cognition: a multicenter cross-sectional cohort study

Background and aimsDementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency of physical exercise (physical exercise), we investigated the association between frequency of PE and cognition in Chinese old adults.Methods16,181 Chinese participants aged 65 years or older were included in this study. Associations between PE and cognition were estimated multivariate logistic and linear regression analyses. Associations were further investigated across dementia subtypes (Alzheimer dementia, vascular dementia, and other types of dementia). Subgroup analyses were performed in different age groups, in populations with and without stroke, and those with and without hypertension.ResultsPE associated with dementia after adjusting for full covariates (OR: 0.5414, 95% CI: 0.4536–0.6491, p < 0.001). Exercise performed at ≥3 times/week associated with lower risk of dementia (OR: 0.4794–0.6619, all p value <0.001). PE was associated with improved cognition (β: 12851, p < 0.001), and any PE frequency contributed to cognitive improvement (p values for exercise performed ≥1 time/week were <0.001). Similar conclusions were identified when we repeated analyses in different dementia subtypes and age groups. Subgroup analyses suggested that the cognition of individuals without hypertension also benefitted from exercising 1–2 times/week (OR: 0.6168, 95% CI: 0.4379–0.8668, p = 0.005).ConclusionThe best exercise frequency is exercising ≥3 times/week for individuals from different dementia subtypes and age groups. While for those without hypertension, PE at 1–2 times /week is also beneficial

Thrombectomy with Solitaire stent for treating acute middle cerebral artery occlusion

Objective To assess the efficacy and safety of thrombectomy with Solitaire stent for treatment of acute middle cerebral artery occlusion (MCAO), and to identify the predictive factors for clinical outcome. Methods A total of 25 patients with acute middle cerebral artery (MCA)-M1 segment occlusion were treated by thrombectomy with Solitaire stent. Time from onset to femoral artery puncture, time from femoral artery puncture to recanalization, times of thrombectomy, thrombolytic therapy or not, balloon dilatation and/or stent implantation, intraarterial thrombolysis or not, tirofiban treatment after therapy or not were recorded. Vascular recanalization immediately after procedure was evaluated by Thrombolysis in Cerebral Infarction (TICI). National Institutes of Health Stroke Scale (NIHSS) was used to evaluate neurological function of patients 24 h after operation, and the clinical outcomes were assessed by modified Rankin Scale (mRS) at 90 d after treatment. The occurrence rate of symptomatic intracranial hemorrhage within 24 h after operation and mortality within 90 d after treatment were recorded. Results Median time from onset to femoral artery puncture was 5.00 (4.00, 6.30) h; median time from femoral artery puncture to recanalization was 2.00 (2.00, 2.50) h; times of thrombectomy was 2 (2, 2); 7 patients (28%) received intravenous thrombolysis before thrombectomy; 6 patients (24%) underwent balloon dilatation only; 3 patients (12%) underwent stent implantation only; 4 patients (16%) underwent balloon dilatation and stent implantation; 4 patients (16%) received intraarterial thrombolysis after thrombectomy; 11 (44%) received tirofiban therapy after operation. There were 20 patients (80% ) of recanalization with TICI 2b-3 grade. The NIHSS score at 24 h after operation was significantly decreased than before procedure [8 (4, 12) score vs. 14 (11, 17) score; Z = -3.532, P = 0.000]. Symptomatic intracranial hemorrhage occurred in 3 patients (12%). At 90 d after treatment, 15 patients (60%) had favorable prognosis (mRS ≤ 2 score). Two patients (8%) died. Univariate and multivariate forward Logistic regression analysis showed the TICI 2b-3 grade was independent factor for favorable prognosis (OR = 0.316, 95% CI: 0.102-0.982; P = 0.046). Conclusions Thrombectomy with Solitaire stent is safe and effective for treating acute MCAO. With the increase of TICI grade, the prognosis is better. DOI: 10.3969/j.issn.1672-6731.2017.11.00