Spatiotemporal patterns and spatial risk factors for visceral leishmaniasis from 2007 to 2017 in Western and Central China: a modelling analysis

Visceral leishmaniasis (VL) is a neglected disease caused by trypanosomatid protozoa in the genus Leishmania, which is transmitted by phlebotomine sandflies. Although this vector-borne disease has been eliminated in several regions of China during the last century, the reported human VL cases have rebounded in Western and Central China in recent decades. However, understanding of the spatial epidemiology of the disease remains vague, as the spatial risk factors driving the spatial heterogeneity of VL. In this study, we analyzed the spatiotemporal patterns of annual human VL cases in Western and Central China from 2007 to 2017. Based on the related spatial maps, the boosted regression tree (BRT) model was adopted to explore the relationships between VL and spatial correlates as well as predicting both the existing and potential infection risk zones of VL in Western and Central China. The mined links reveal that elevation, minimum temperature, relative humidity, and annual accumulated precipitation make great contributions to the spatial heterogeneity of VL. The maps show that Xinjiang Uygur Autonomous Region, Gansu, western Inner Mongolia Autonomous Region, and Sichuan are predicted to fall in the highest infection risk zones of VL. Approximately 61.60 million resident populations lived in the high-risk regions of VL in Western and Central China. Our results provide a better understanding of how spatial risk factors driving VL spread as well as identifying the potential endemic risk region of VL, thereby enhancing the biosurveillance capacity of public health authorities

The epidemiology of Plasmodium vivax and Plasmodium falciparum malaria in China, 2004–2012: from intensified control to elimination

BACKGROUND In China, the national malaria elimination programme has been operating since 2010. This study aimed to explore the epidemiological changes in patterns of malaria in China from intensified control to elimination stages. METHODS Data on nationwide malaria cases from 2004 to 2012 were extracted from the Chinese national malaria surveillance system. The secular trend, gender and age features, seasonality, and spatial distribution by Plasmodium species were analysed. RESULTS In total, 238,443 malaria cases were reported, and the proportion of Plasmodium falciparum increased drastically from <10% before 2010 to 55.2% in 2012. From 2004 to 2006, malaria showed a significantly increasing trend and with the highest incidence peak in 2006 (4.6/100,000), while from 2007 onwards, malaria decreased sharply to only 0.18/100,000 in 2012. Males and young age groups became the predominantly affected population. The areas affected by Plasmodium vivax malaria shrunk, while areas affected by P. falciparum malaria expanded from 294 counties in 2004 to 600 counties in 2012. CONCLUSIONS This study demonstrated that malaria has decreased dramatically in the last five years, especially since the Chinese government launched a malaria elimination programme in 2010, and areas with reported falciparum malaria cases have expanded over recent years. These findings suggest that elimination efforts should be improved to meet these changes, so as to achieve the nationwide malaria elimination goal in China in 2020.This study was supported by grants from the Ministry of Science and Technology of China (2012ZX10004-201, 2012ZX10004-220) and the Ministry of Health of China (No. 201202006), and China UK Global Health Support Programme (grant no. GHSP-CS-OP1). S.I.H. is funded by a Senior Research Fellowship from the Wellcome Trust (#095066). S.I.H. also acknowledges funding support from the RAPIDD programme of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health

Population pharmacokinetics of Amisulpride in Chinese patients with schizophrenia with external validation: the impact of renal function

Introduction: Amisulpride is primarily eliminated via the kidneys. Given the clear influence of renal clearance on plasma concentration, we aimed to explicitly examine the impact of renal function on amisulpride pharmacokinetics (PK) via population PK modelling and Monte Carlo simulations.Method: Plasma concentrations from 921 patients (776 in development and 145 in validation) were utilized.Results: Amisulpride PK could be described by a one-compartment model with linear elimination where estimated glomerular filtration rate, eGFR, had a significant influence on clearance. All PK parameters (estimate, RSE%) were precisely estimated: apparent volume of distribution (645 L, 18%), apparent clearance (60.5 L/h, 2%), absorption rate constant (0.106 h−1, 12%) and coefficient of renal function on clearance (0.817, 10%). No other significant covariate was found. The predictive performance of the model was externally validated. Covariate analysis showed an inverse relationship between eGFR and exposure, where subjects with eGFR= 30 mL/min/1.73 m2 had more than 2-fold increase in AUC, trough and peak concentration. Simulation results further illustrated that, given a dose of 800 mg, plasma concentrations of all patients with renal impairment would exceed 640 ng/mL.Discussion: Our work demonstrated the importance of renal function in amisulpride dose adjustment and provided a quantitative framework to guide individualized dosing for Chinese patients with schizophrenia

Epidemiological characteristics and risk factors for cystic and alveolar echinococcosis in China: an analysis of a national population-based field survey

Background Human cystic and alveolar echinococcosis are neglected tropical diseases that WHO has prioritized for control in recent years. Both diseases impose substantial burdens on public health and the socio-economy in China. In this study, which is based on the national echinococcosis survey from 2012 to 2016, we aim to describe the spatial prevalence and demographic characteristics of cystic and alveolar echinococcosis infections in humans and assess the impact of environmental, biological and social factors on both types of the disease. Methods We computed the sex-, age group-, occupation- and education level-specific prevalences of cystic and alveolar echinococcosis at national and sub-national levels. We mapped the geographical distribution of echinococcosis prevalence at the province, city and county levels. Finally, by analyzing the county-level echinococcosis cases combined with a range of associated environmental, biological and social factors, we identified and quantified the potential risk factors for echinococcosis using a generalized linear model. Results A total of 1,150,723 residents were selected and included in the national echinococcosis survey between 2012 and 2016, of whom 4161 and 1055 tested positive for cystic and alveolar echinococcosis, respectively. Female gender, older age, occupation at herdsman, occupation as religious worker and illiteracy were identified as risk factors for both types of echinococcosis. The prevalence of echinococcosis was found to vary geographically, with areas of high endemicity observed in the Tibetan Plateau region. Cystic echinococcosis prevalence was positively correlated with cattle density, cattle prevalence, dog density, dog prevalence, number of livestock slaughtered, elevation and grass area, and negatively associated with temperature and gross domestic product (GDP). Alveolar echinococcosis prevalence was positively correlated with precipitation, level of awareness, elevation, rodent density and rodent prevalence, and negatively correlated with forest area, temperature and GDP. Our results also implied that drinking water sources are significantly associated with both diseases. Conclusions The results of this study provide a comprehensive understanding of geographical patterns, demographic characteristics and risk factors of cystic and alveolar echinococcosis in China. This important information will contribute towards developing targeted prevention measures and controlling diseases from the public health perspective. Graphical Abstract

Research on the Influence of the Change of Consumption Concept on the Development of Digital Products in the Post Epidemic Era

The outbreak of the COVID-19 epidemic has caused a huge impact on the global economy. Great changes have taken place in people’s consumption patterns. In order to explore the changes of people’s consumption concept in the post epidemic era, and the impact of these changes on digital products, this paper analyzes the changes of consumption concept from different life scenes such as life, work, learning, entertainment. Then, the article summarizes the development trend of digital products in the post epidemic era. Finally, the key points of future digital product design are put forward

Research on the Influence of the Change of Consumption Concept on the Development of Digital Products in the Post Epidemic Era

The outbreak of the COVID-19 epidemic has caused a huge impact on the global economy. Great changes have taken place in people’s consumption patterns. In order to explore the changes of people’s consumption concept in the post epidemic era, and the impact of these changes on digital products, this paper analyzes the changes of consumption concept from different life scenes such as life, work, learning, entertainment. Then, the article summarizes the development trend of digital products in the post epidemic era. Finally, the key points of future digital product design are put forward

Spatiotemporal Variation and Hot Spot Detection of Visceral Leishmaniasis Disease in Kashi Prefecture, China

Visceral leishmaniasis (VL) remains a serious public health problem in China. To explore the temporal, spatial, and spatiotemporal characteristics of visceral leishmaniasis (VL), the spatial and spatiotemporal clustering distribution and their relationships with the surrounding geographic environmental factors were analyzed. In this study, the average nearest-neighbor distance (ANN), Ripley&#8217;s K-function and Moran&#8217;s I statistics were used to evaluate spatial autocorrelation in the VL distribution of the existing case patterns. Getis&#8315;Ord Gi* was used to identify the hot-spot and cold-spot areas based on Geographic Information System (GIS), and spatiotemporal retrospective permutation scan statistics was used to detect the spatiotemporal clusters. The results indicated that VL continues to be a serious public health problem in Kashi Prefecture, China, particularly in the north-central region of Jiashi County, which is a relatively high-risk area in which hot spots are distributed. Autumn and winter months were the outbreak season for VL cases. The detection of spatial and spatiotemporal patterns can provide epidemiologists and local governments with significant information for prevention measures and control strategies

Design and Kinematic Characteristic Analysis of a Spiral Robot for Oil and Gas Pipeline Inspections

This study presents a spiral pipeline robot designed for detecting and preventing oil and gas pipeline leakages. A comprehensive analysis of factors such as spiral angle, normal force, pipe material, and operating attitude is conducted based on the robot’s mechanical model in a straight pipe. This in-depth investigation determines the optimal spiral angle, normal force, pipeline material, and operating attitude to enhance the robot’s motion stability and traction performance. Using virtual prototype technology, the robot’s traction performance is simulated under various working conditions, normal forces, and attitude angles within the pipeline. An experimental platform is established to verify the impact of deflection angle, normal force, and pipeline material on traction performance. The experimental results and simulation analysis mutually validate each other, providing a reliable reference for robot design and optimization. The spiral pipeline robot and its motion strategy proposed in this study possess both theoretical value and practical application prospects in the field of oil and gas pipeline inspection and maintenance

Spatial quadric calibration method for multi-line laser based on diffractive optical element

The traditional multi-line laser calibration method relies primarily on calibrating the spatial plane equations of multiple laser lines and reconstructing the multi-line laser in three dimensions through the plane equation and camera parameters. In traditional methods, the multi-line laser is projected as a straight line by default, but in reality, the laser line projected by the multi-line laser is not a plane due to the Diffractive Optical Element (DOE). Instead, it is a surface with a certain curvature in space. During the production process, the multi-line laser experiences significant distortion because of the DOE projecting at a large angle. Consequently, if traditional methods are used, accurate calibration of the multi-line laser cannot be achieved. To address this issue, this paper introduces a new calibration algorithm for multi-line laser based on a spatial quadric equation. By calibrating the spatial quadric equation of the multi-line laser, the spatial characteristics of the laser can be accurately captured. The algorithm involves projecting a crossed 7-line laser onto a calibration plate and changing the position of the calibration plate while capturing images. This allows for obtaining the spatial three-dimensional coordinates of each laser line in the camera coordinate system. Next, spatial quadric equations are fitted for each laser line based on the three-dimensional coordinates. Finally, 3D reconstruction is performed using the quadratic surface parameters of the multi-line laser and camera parameters. The results from 3D reconstruction demonstrate that, compared to traditional laser calibration methods based on planes, the proposed algorithm achieves higher calibration accuracy. It also improves the number of successful binocular multi-line laser matches and overall accuracy