Does the importance of sustainable event information services vary among generational sub-cohorts?

As events embrace sustainability – many information services have shifted to virtual – how does that affect the importance of these services – and affect satisfaction? And does it affect various generational groups differently? The present study found that it does.N/

The Role of Relationship in Determining Event Satisfaction Attributes

While extensive research has focused on satisfaction and loyalty relating to tourism destinations and tourism festivals/events, that research has tended to be centered on the drivers of satisfaction and loyalty. The current study uses discriminant function analysis to assess the role of relationship or marital status on the drivers of satisfaction and loyalty. The results suggest that married couples, singles, and those in relationships have distinctly different drivers of satisfaction when it comes to festival attributes. Specifically, the study suggests that married couples’ satisfaction is more strongly related to the festivals’ facilities and souvenirs than singles and those in relationships, while singles satisfaction appears to be driven by activities and entertainment. The study proposes important theoretical and practical implications for marketing tourism festivals and events and suggests future research to expand the results to include destinations

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

Pregnane X receptor (PXR) which belongs to the nuclear hormone receptor superfamily plays vital roles in several biological functions, especially in the inflammatory procedure. Besides that, PXR is revealed by recent studies to have essential effects on bone tissue. As an agonist of PXR, meclizine is a piperazine-derived histamine H1 antagonist, and has been frequently used for prevention and treatment of vomiting and nausea. Because osteoclastogenesis is characterized by the activation of inflammation-related signaling pathways, we speculated that meclizine may affect formation and function of osteoclast. In the present study, we explored the effect of meclizine on RANKL-induced osteoclastogenesis both in vivo and in vitro. In primary bone marrow-derived macrophages (BMMs), meclizine reduced osteoclast formation and bone resorption in a dose-dependent manner, while knockdown of PXR with siRNA partially abrogated the osteoclastogenesis inhibition of meclizine. On the one hand, at the molecular level, meclizine attenuated RANKL-induced activation of c-Fos, NFATc1, nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPKs), including ERK and p38, but not JNK. Meanwhile, meclizine reduced the expression of osteoclast-specific genes, including TRAP, MMP9, Cathepsin K and NFATc1. On the other hand, meclizine decreased OVX-induced bone loss by repressing osteoclast activity. In conclusion, our results indicated that meclizine inhibits osteoclastogenesis via regulation of several RANKL signaling pathways and PXR was involved in the processes. Therefore, meclizine may be considered as a novel therapeutic candidate for osteoclast-related diseases