61 research outputs found
An Overview on IEEE 802.11bf: WLAN Sensing
With recent advancements, the wireless local area network (WLAN) or wireless
fidelity (Wi-Fi) technology has been successfully utilized to realize sensing
functionalities such as detection, localization, and recognition. However, the
WLANs standards are developed mainly for the purpose of communication, and thus
may not be able to meet the stringent requirements for emerging sensing
applications. To resolve this issue, a new Task Group (TG), namely IEEE
802.11bf, has been established by the IEEE 802.11 working group, with the
objective of creating a new amendment to the WLAN standard to meet advanced
sensing requirements while minimizing the effect on communications. This paper
provides a comprehensive overview on the up-to-date efforts in the IEEE
802.11bf TG. First, we introduce the definition of the 802.11bf amendment and
its formation and standardization timeline. Next, we discuss the WLAN sensing
use cases with the corresponding key performance indicator (KPI) requirements.
After reviewing previous WLAN sensing research based on communication-oriented
WLAN standards, we identify their limitations and underscore the practical need
for the new sensing-oriented amendment in 802.11bf. Furthermore, we discuss the
WLAN sensing framework and procedure used for measurement acquisition, by
considering both sensing at sub-7GHz and directional multi-gigabit (DMG)
sensing at 60 GHz, respectively, and address their shared features,
similarities, and differences. In addition, we present various candidate
technical features for IEEE 802.11bf, including waveform/sequence design,
feedback types, as well as quantization and compression techniques. We also
describe the methodologies and the channel modeling used by the IEEE 802.11bf
TG for evaluation. Finally, we discuss the challenges and future research
directions to motivate more research endeavors towards this field in details.Comment: 31 pages, 25 figures, this is a significant updated version of
arXiv:2207.0485
Cdx4 and Menin Co-Regulate Hoxa9 Expression in Hematopoietic Cells
BACKGROUND: Transcription factor Cdx4 and transcriptional coregulator menin are essential for Hoxa9 expression and normal hematopoiesis. However, the precise mechanism underlying Hoxa9 regulation is not clear. METHODS AND FINDINGS: Here, we show that the expression level of Hoxa9 is correlated with the location of increased trimethylated histone 3 lysine 4 (H3K4M3). The active and repressive histone modifications co-exist along the Hoxa9 regulatory region. We further demonstrate that both Cdx4 and menin bind to the same regulatory region at the Hoxa9 locus in vivo, and co-activate the reporter gene driven by the Hoxa9 cis-elements that contain Cdx4 binding sites. Ablation of menin abrogates Cdx4 access to the chromatin target and significantly reduces both active and repressive histone H3 modifications in the Hoxa9 locus. CONCLUSION: These results suggest a functional link among Cdx4, menin and histone modifications in Hoxa9 regulation in hematopoietic cells
A Fault-Line Selection Method for Small-Current Grounded System Based on Deep Transfer Learning
Usually, data-driven methods require many samples and need to train a specific model for each substation instance. As different substation instances have similar fault features, the number of samples required for model training can be significantly reduced if these features are transferred to the substation instances that lack samples. This paper proposes a fault-line selection (FLS) method based on deep transfer learning for small-current grounded systems to solve the problems of unstable training and low FLS accuracy of data-driven methods in small-sample cases. For this purpose, fine-turning and historical averaging techniques are proposed for use in transfer learning to extract similar fault features from other substation instances and transfer these features to target substation instances that lack samples to improve the accuracy and stability of the model. The results show that the proposed method obtains a much higher FLS accuracy than other methods in small-sample cases; it has a strong generalization ability, low misclassification rate, and excellent application value
Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice
Diabetes ultimately results from an inadequate number of functional beta cells in the islets of Langerhans. Enhancing proliferation of functional endogenous beta cells to treat diabetes remains underexplored. Here, we report that excision of the Men1 gene, whose loss-of-function mutation leads to inherited multiple endocrine neoplasia type 1 (MEN1), rendered resistant to streptozotocin-induced hyperglycemia in a tamoxifen-inducible and temporally controlled Men1 excision mouse model as well as in a tissue-specific Men1 excision mouse model. Men1 excision prevented mice from streptozotocin-induced hyperglycemia mainly through increasing the number of functional beta cells. BrdU incorporation by beta cells, islet size, and circulating insulin levels were significantly increased in Men1-excised mice. Membrane localization of glucose transporter 2 was largely preserved in Men1-excised beta cells, but not in Men1-expressing beta cells. Our findings suggest that repression of menin, a protein encoded by the Men1 gene, might be a valuable means to maintain or increase the number of functional endogenous beta cells to prevent or ameliorate diabetes
Harnessing the Hidden Antitumor Power of the MLL-AF4 Oncogene to Fight Leukemia
It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologically reactivated in cancer cells. In this issue of Cancer Cell, Liu and colleagues report that a proteasome inhibitor reactivates an MLL-AF4 controlled antitumor program to kill leukemia cells in an oncogene dose- and cell type-dependent manner
Critical Role of Smad and AP-1 Complexes in TGF-Ξ²-Dependent Apoptosis
Transforming growth factor-Ξ²1 (TGF-Ξ²1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which
transmit TGF-Ξ²1 signal for growth inhibition from the TGF-Ξ² receptors to the nucleus (1, 2). However, their roles are unclear in the induction of apoptosis. Our results show here that both Smad and AP-1 complexes play a critical role in TGF-Ξ²1 signaling for apoptosis.National Institutes of Health (U.S.) (Grant CA63260
Diagnosis of pairing symmetry by vortex and edge spectra in kagome superconductors
Layered kagome metals AV3Sb5 (A=K, Rb, Cs) exhibit diverse correlated
electron phenomena. It includes charge density wave formation and
superconductivity the pairing symmetry of which, however, is controversial due
to contradictory experimental evidence. Through calculations based on
real-space lattice models at the mean-field level, we investigate the vortex
and surface spectra of all competitive pairing propensities suggested for
AV3Sb5 from a weak coupling analysis of unconventional superconductivity.
Chiral p-wave pairing emerges as the only option to host Majorana bound states
in the vortex core. We find chiral edge states for both p-wave and d-wave
pairing, along with flat Andreev surface bound states for f -wave pairing. Our
results expand the fingerprint of superconducting pairing, and thus will
contribute to resolving the nature of superconductivity in AV3Sb5.Comment: 7 pages, 8 figure
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