Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-3

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p>vels in human corneal epithelial cells treated with hyphal fragments alon

Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-7

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p

Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-2

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p> epithelial cell

Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-0

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p

Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-6

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p

Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-1

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p>l epithelial cell

Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells-4

<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of in immortalized human corneal epithelial cells"</p><p></p><p>Molecular Vision 2007;13():1953-1961.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2185515.</p><p></p>carbamidine dihydrochlorid

Additional file 1 of Differences in choroidal responses to near work between myopic children and young adults

Additional file 1. Illustration of the time course of the experiments

Adenomatous Polyposis Coli Mutation Leads to Myopia Development in Mice

<div><p>Myopia incidence in China is rapidly becoming a very serious sight compromising problem in a large segment of the general population. Therefore, delineating the underlying mechanisms leading to myopia will markedly lessen the likelihood of other sight compromising complications. In this regard, there is some evidence that patients afflicted with familial adenomatous polyposis (FAP), havean adenomatous polyposis coli (APC) mutation and a higher incidence of myopia. To clarify this possible association, we determined whether the changes in pertinent biometric and biochemical parameters underlying postnatal refractive error development in APC^Min mice are relevant for gaining insight into the pathogenesis of this disease in humans. The refraction and biometrics in APC^Min mice and age-matched wild-type (WT) littermates between postnatal days P28 and P84 were examined with eccentric infrared photorefraction (EIR) and customized optical coherence tomography (OCT). Compared with WT littermates, the APC^Min mutated mice developed myopia (average -4.64 D) on P84 which was associated with increased vitreous chamber depth (VCD). Furthermore, retinal and scleral changes appear in these mice along with: 1) axial length shortening; 2) increased retinal cell proliferation; 3) and decreased tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of DA synthesis. Scleral collagen fibril diameters became heterogeneous and irregularly organized in the APC^Min mice. Western blot analysis showed that scleral alpha-1 type I collagen (col1α1) expression also decreased whereas MMP2 and MMP9 mRNA expression was invariant. These results indicate that defective APC gene function promotes refractive error development. By characterizing in APC^Min mice ocular developmental changes, this approach provides novel insight into underlying pathophysiological mechanisms contributing to human myopia development.</p></div

Sequences for primers and RT-PCR product length.

<p>Sequences for primers and RT-PCR product length.</p