Designing Functional Carriage of High-Speed Medical Train – Systematic Analysis and Evaluation of Tasks, Functions and Flow Routes

This paper proposes a functional carriage design and an evaluation index system to improve the operational efficiency of high-speed medical trains. Hierarchical task analysis and human-machine-environment analysis were applied to model the transfer task and the functional modules of the medical train. The functional module configuration was obtained by performing a correlation analysis between the task and function. The relationship between carriages was elucidated by analysing material, personnel and information flow, and an optimal grouping diagram was obtained. Based on this design method, an innovative 6-carriage grouping design scheme was proposed. A functional evaluation index system for the carriage design was constructed, and the 6-carriage design was compared with the conventional 8-carriage design to verify the usability of the design method. The results showed that the 6-carriage high-speed trains can be flexibly configured to suit the changing task environment and are generally better than the 8-carriage design. This study provides theoretical and methodological support for constructing efficient and rational functional carriages for high-speed medical trains

Designing Functional Carriage of High-Speed Medical Train – Systematic Analysis and Evaluation of Tasks, Functions and Flow Routes

This paper proposes a functional carriage design and an evaluation index system to improve the operational efficiency of high-speed medical trains. Hierarchical task analysis and human-machine-environment analysis were applied to model the transfer task and the functional modules of the medical train. The functional module configuration was obtained by performing a correlation analysis between the task and function. The relationship between carriages was elucidated by analysing material, personnel and information flow, and an optimal grouping diagram was obtained. Based on this design method, an innovative 6-carriage grouping design scheme was proposed. A functional evaluation index system for the carriage design was constructed, and the 6-carriage design was compared with the conventional 8-carriage design to verify the usability of the design method. The results showed that the 6-carriage high-speed trains can be flexibly configured to suit the changing task environment and are generally better than the 8-carriage design. This study provides theoretical and methodological support for constructing efficient and rational functional carriages for high-speed medical trains

Design and Evaluation of the Internal Space Layout of High-Speed Health Trains Based on Improved Systematic Layout Planning

High-speed health trains have the advantages of large rescue volume, strong continuous operation capability, and medical treatment on the way. It is the best transport platform for large-scale medical transfer tasks. To solve the problem of space limitations and the vehicle formation of high-speed health trains, a new method of space layout design and evaluation of high-speed health trains based on improved systematic layout planning (SLP) was proposed. First, SLP was improved, and the relationship between functional carriages was reasonably marshaled using the improved SLP. Then, according to the space constraints of high-speed trains and the requirements of the man–machine environment, the space layout of the vehicles was designed, and 3ds MAX software was used to visualize the designed layout structure. Finally, the static and dynamic simulation effects and adaptability of the design scheme were evaluated using the digital virtual simulation software JACK. The design scheme can meet the requirements of human–computer interaction efficiency. Compared with previous studies, the results of this study reflect the superiority and rationality of the design in functional configuration, space utilization, medical treatment, and injury-carrying capacity. The results of this study can provide theoretical support for the formation of high-speed health trains, and provide a reference for the research and development of such trains. It has certain practical application value

Risk factors for mortality in patients with acute exacerbation of cor pulmonale in plateau

Abstract Background The risk factors for mortality might differ between patients with acute exacerbation of chronic pulmonary heart disease in plains and plateaus, while there is a lack of evidence. Method Patients diagnosed with cor pulmonale at Qinghai Provincial People’s Hospital were retrospectively included between January 2012 and December 2021. The symptoms, physical and laboratory examination findings, and treatments were collected. Based on the survival within 50 days, we divided the patients into survival and death groups. Results After 1:10 matching according to gender, age, and altitude, 673 patients were included in the study, 69 of whom died. The multivariable Cox proportional hazards analysis showed that NYHA class IV (HR = 2.03, 95%CI: 1.21–3.40, P = 0.007), type II respiratory failure (HR = 3.57, 95%CI: 1.60–7.99, P = 0.002), acid-base imbalance (HR = 1.82, 95%CI: 1.06–3.14, P = 0.031), C-reactive protein (HR = 1.04, 95%CI: 1.01–1.08, P = 0.026), and D-dimer (HR = 1.07, 95%CI: 1.01–1.13, P = 0.014) were risk factors for death in patients with cor pulmonale at high altitude. Among patients living below 2500 m, cardiac injury was a risk factor for death (HR = 2.47, 95%CI: 1.28–4.77, P = 0.007), while no significant association was observed at ≥ 2500 m (P = 0.057). On the contrary, the increase of D-dimer was only a risk factor for the death of patients living 2500 m and above (HR = 1.23, 95% CI: 1.07–1.40, P = 0.003). Conclusion NYHA class IV, type II respiratory failure, acid-base imbalance, and C- reactive protein may increase the risk of death in patients with cor pulmonale. Altitude modified the association between cardiac injury, D-dimer, and death in patients with cor pulmonale

Quiescin-sulfhydryl oxidase inhibits prion formation <i>in vitro</i>

International audiencePrions are infectious proteins that cause a group of fatal transmissible diseases in animals and humans. The scrapie isoform (PrPSc) of the cellular prion protein (PrPC) is the only known component of the prion. Several lines of evidence have suggested that the formation and molecular features of PrPSc are associated with an abnormal unfolding/refolding process. Quiescin-sulfhydryl oxidase (QSOX) plays a role in protein folding by introducing disulfides into unfolded reduced proteins. Here we report that QSOX inhibits human prion propagation in protein misfolding cyclic amplification reactions and murine prion propagation in scrapie-infected neuroblastoma cells. Moreover, QSOX preferentially binds PrPSc from prion-infected human or animal brains, but not PrPC from uninfected brains. Surface plasmon resonance of the recombinant mouse PrP (moPrP) demonstrates that the affinity of QSOX for monomer is significantly lower than that for octamer (312 nM vs 1.7 nM). QSOX exhibits much lower affinity for N-terminally truncated moPrP (PrP89-230) than for the full-length moPrP (PrP23-231) (312 nM vs 2 nM), suggesting that the N-terminal region of PrP is critical for the interaction of PrP with QSOX. Our study indicates that QSOX may play a role in prion formation, which may open new therapeutic avenues for treating prion diseases

Photoactivated Formation of an Extravascular Dynamic Hydrogel as an Intelligent Blood Flow Regulator to Reprogram the Immunogenic Landscape

Long-term tumor starvation may be a potential strategy to elevate the antitumor immune response by depriving nutrients. However, combining long-term starvation therapy with immunotherapy often yields limited efficacy due to the blockage of immune cell migration pathways. Herein, an intelligent blood flow regulator (BFR) is first established through photoactivated in situ formation of the extravascular dynamic hydrogel to compress blood vessels, which can induce long-term tumor starvation to elicit metabolic stress in tumor cells without affecting immune cell migration pathways. By leveraging methacrylate-modified nanophotosensitizers (HMMAN) and biodegradable gelatin methacrylate (GelMA), the developed extravascular hydrogel dynamically regulates blood flow via enzymatic degradation. Additionally, aPD-L1 loaded into HMMAN continuously blocks immune checkpoints. Systematic in vivo experiments demonstrate that the combination of immune checkpoint blockade (ICB) and BFR-induced metabolic stress (BIMS) significantly delays the progression of Lewis lung and breast cancers by reshaping the tumor immunogenic landscape and enhancing antitumor immune responses

Photoactivated Formation of an Extravascular Dynamic Hydrogel as an Intelligent Blood Flow Regulator to Reprogram the Immunogenic Landscape

Long-term tumor starvation may be a potential strategy to elevate the antitumor immune response by depriving nutrients. However, combining long-term starvation therapy with immunotherapy often yields limited efficacy due to the blockage of immune cell migration pathways. Herein, an intelligent blood flow regulator (BFR) is first established through photoactivated in situ formation of the extravascular dynamic hydrogel to compress blood vessels, which can induce long-term tumor starvation to elicit metabolic stress in tumor cells without affecting immune cell migration pathways. By leveraging methacrylate-modified nanophotosensitizers (HMMAN) and biodegradable gelatin methacrylate (GelMA), the developed extravascular hydrogel dynamically regulates blood flow via enzymatic degradation. Additionally, aPD-L1 loaded into HMMAN continuously blocks immune checkpoints. Systematic in vivo experiments demonstrate that the combination of immune checkpoint blockade (ICB) and BFR-induced metabolic stress (BIMS) significantly delays the progression of Lewis lung and breast cancers by reshaping the tumor immunogenic landscape and enhancing antitumor immune responses

Photoactivated Formation of an Extravascular Dynamic Hydrogel as an Intelligent Blood Flow Regulator to Reprogram the Immunogenic Landscape

Long-term tumor starvation may be a potential strategy to elevate the antitumor immune response by depriving nutrients. However, combining long-term starvation therapy with immunotherapy often yields limited efficacy due to the blockage of immune cell migration pathways. Herein, an intelligent blood flow regulator (BFR) is first established through photoactivated in situ formation of the extravascular dynamic hydrogel to compress blood vessels, which can induce long-term tumor starvation to elicit metabolic stress in tumor cells without affecting immune cell migration pathways. By leveraging methacrylate-modified nanophotosensitizers (HMMAN) and biodegradable gelatin methacrylate (GelMA), the developed extravascular hydrogel dynamically regulates blood flow via enzymatic degradation. Additionally, aPD-L1 loaded into HMMAN continuously blocks immune checkpoints. Systematic in vivo experiments demonstrate that the combination of immune checkpoint blockade (ICB) and BFR-induced metabolic stress (BIMS) significantly delays the progression of Lewis lung and breast cancers by reshaping the tumor immunogenic landscape and enhancing antitumor immune responses