71 research outputs found
-Metric: An N-Dimensional Information-Theoretic Framework for Groupwise Registration and Deep Combined Computing
This paper presents a generic probabilistic framework for estimating the
statistical dependency and finding the anatomical correspondences among an
arbitrary number of medical images. The method builds on a novel formulation of
the -dimensional joint intensity distribution by representing the common
anatomy as latent variables and estimating the appearance model with
nonparametric estimators. Through connection to maximum likelihood and the
expectation-maximization algorithm, an information\hyp{}theoretic metric called
-metric and a co-registration algorithm named -CoReg
are induced, allowing groupwise registration of the observed images with
computational complexity of . Moreover, the method naturally
extends for a weakly-supervised scenario where anatomical labels of certain
images are provided. This leads to a combined\hyp{}computing framework
implemented with deep learning, which performs registration and segmentation
simultaneously and collaboratively in an end-to-end fashion. Extensive
experiments were conducted to demonstrate the versatility and applicability of
our model, including multimodal groupwise registration, motion correction for
dynamic contrast enhanced magnetic resonance images, and deep combined
computing for multimodal medical images. Results show the superiority of our
method in various applications in terms of both accuracy and efficiency,
highlighting the advantage of the proposed representation of the imaging
process
BInGo: Bayesian Intrinsic Groupwise Registration via Explicit Hierarchical Disentanglement
Multimodal groupwise registration aligns internal structures in a group of
medical images. Current approaches to this problem involve developing
similarity measures over the joint intensity profile of all images, which may
be computationally prohibitive for large image groups and unstable under
various conditions. To tackle these issues, we propose BInGo, a general
unsupervised hierarchical Bayesian framework based on deep learning, to learn
intrinsic structural representations to measure the similarity of multimodal
images. Particularly, a variational auto-encoder with a novel posterior is
proposed, which facilitates the disentanglement learning of structural
representations and spatial transformations, and characterizes the imaging
process from the common structure with shape transition and appearance
variation. Notably, BInGo is scalable to learn from small groups, whereas being
tested for large-scale groupwise registration, thus significantly reducing
computational costs. We compared BInGo with five iterative or deep learning
methods on three public intrasubject and intersubject datasets, i.e. BraTS,
MS-CMR of the heart, and Learn2Reg abdomen MR-CT, and demonstrated its superior
accuracy and computational efficiency, even for very large group sizes (e.g.,
over 1300 2D images from MS-CMR in each group)
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