A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022

ObjectiveTo explore the development context, research hotspots and frontiers in the glymphatic system (GS) field from 2012 to 2022 by bibliometric analysis.MethodsThe Web of Science Core Collection (WoSCC) database was searched for articles published between 2012 and 2022. Microsoft Excel was used to manage the data. VOSviewer, CiteSpace, GraphPad Prism, the Web of Science, and an online analysis platform for bibliometrics (http://bibliometric.com/) were used to analyze the countries, institutions, journals, and collaboration networks among authors and the types of articles, developmental directions, references, and top keywords of published articles.ResultsA total of 412 articles were retrieved, including 39 countries/regions, 223 research institutes and 171 academic journals. The subject classifications related to the GS were Neuroscience, Clinical Neuroscience and Radiology/Nuclear Medicine/Medical Imaging. The United States has maintained its dominant and most influential position in GS research. Among research institutions and journals, the Univ Rochester and Journal of Cerebral Blood Flow and Metabolism had the highest number of academic articles, respectively. Nedergaard M had the most published article, and Iliff JJ had the most co-citations. The top two keywords with the highest frequency were “glymphatic system” and “cerebrospinal fluid.”ConclusionThis research provides valuable information for the study of the GS. The bibliometric analysis of this area will encourage potential collaborations among researchers, defining its frontiers and directions for development

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers in mainland China. We collected demographic, medical history, treatment, laboratory, disease severity, and mortality data from all patients. Investigators at each site were asked to complete causality assessments for each case whose diagnosis at discharge was DILI (n=29,478) according to the Roussel Uclaf Causality Assessment Method.Results: Most cases of DILI presented with hepatocellular injury (51.39%; 95% CI, 50.76–52.03), followed by mixed injury (28.30%; 95% CI, 27.73–28.87) and cholestatic injury (20.31%; 95% CI, 19.80–20.82). The leading single classes of implicated drugs were traditional Chinese medicines or herbal and dietary supplements (26.81%) and anti-tuberculosis medications (21.99%). Chronic DILI occurred in 13.00% of the cases and, although 44.40% of the hepatocellular DILI cases fulfilled Hy’s Law criteria, only 280 cases (1.08%) progressed to hepatic failure, 2 cases underwent liver transplantation (0.01%), and 102 patients died (0.39%). Among deaths, DILI was judged to have a primary role in 72 (70.59%), a contributory role in 21 (20.59%), and no role in 9 (8.82%). Assuming the proportion of DILI in the entire hospitalized population of China was represented by that observed in the 66 centers where DILI capture was complete, we estimated the annual incidence in the general population to be 23.80 per 100,000 persons (95% CI, 20.86–26.74). Only hospitalized patients were included in this analysis, so the true incidence is likely to be higher.Conclusions: In a retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China, the annual incidence in the general population was estimated to be 23.80 per 100,000 persons—higher than that reported from western countries. Traditional Chinese medicines, herbal and dietary supplements, and anti-tuberculosis drugs were the leading causes of DILI in mainland Chin

Optimized Sonar Broadband Focused Beamforming Algorithm

Biases of initial direction estimation and focusing frequency selection affect the final focusing effect and may even cause algorithm failure in determining the focusing matrix in the coherent signal⁻subspace method. An optimized sonar broadband focused beamforming algorithm is proposed to address these defects. Initially, the robust Capon beamforming algorithm was used to correct the focusing matrix, and the broadband signals were then focused on the optimal focusing frequency by the corrected focusing matrix such that the wideband beamforming was transformed into a narrowband problem. Finally, the focused narrowband signals were beamformed by the second-order cone programming algorithm. Computer simulation results and water pool experiments verified that the proposed algorithm provides a good performance

Online Detection of Keyhole Status in a Laser-MIG Hybrid Welding Process

During laser-metal inert gas (MIG) hybrid welding, a large amount of welding status information is generated in droplet transfer, keyhole and molten pool. In this paper, austenitic stainless steel was adopted as an experimental object, with a dual high-speed camera system used to obtain real-time images of droplet transfer, keyhole and molten pool in a laser-MIG hybrid welding process. The changing regulation of a keyhole in three different penetration states (i.e., non-penetration, partial penetration and normal penetration) was analyzed by extracting the morphological characteristics of a keyhole shape, and combining the droplet transition information and the shape of the weld pool. Experimental results show that the proposed method could effectively reflect the variation characteristics of the keyhole, and the correlation among the keyhole characteristics, the droplet transfer information, the weld pool shape and the welding status, and provide a new perspective for online detection of the laser-MIG welding quality

Online Detection of Keyhole Status in a Laser-MIG Hybrid Welding Process

During laser-metal inert gas (MIG) hybrid welding, a large amount of welding status information is generated in droplet transfer, keyhole and molten pool. In this paper, austenitic stainless steel was adopted as an experimental object, with a dual high-speed camera system used to obtain real-time images of droplet transfer, keyhole and molten pool in a laser-MIG hybrid welding process. The changing regulation of a keyhole in three different penetration states (i.e., non-penetration, partial penetration and normal penetration) was analyzed by extracting the morphological characteristics of a keyhole shape, and combining the droplet transition information and the shape of the weld pool. Experimental results show that the proposed method could effectively reflect the variation characteristics of the keyhole, and the correlation among the keyhole characteristics, the droplet transfer information, the weld pool shape and the welding status, and provide a new perspective for online detection of the laser-MIG welding quality

Dynamics of Understory Shrub Biomass in Six Young Plantations of Southern Subtropical China

Understory shrubs are an important component of forest ecosystems and drive ecosystem processes, such as ecosystem carbon cycling. However, shrub biomass carbon stocks have rarely been reported, which limits our understanding of ecosystem C stock and cycling. In this study, we evaluated carbon accumulation of shrub species using allometric equations based on height and basal diameter in six subtropical plantations at the age of 1, 3, 4 and 6 years. The results showed that plantation type did not significantly affect the total biomass of shrubs, but it significantly affected the biomass of Rhodomyrtus tomentosa, Ilex asprella, Clerodendrum fortunatum and Baeckea frutescens. The biomass of dominant shrub species R. tomentosa, I. asprella, Gardenia jasminoides and Melastoma candidum increased with stand age, while the biomass of C. fortunatum and B. frutescens decreased. The inconsistent biomass-time patterns of different shrub species may be the primary reason for the altered total shrub biomass in each plantation. Consequently, we proposed that R. tomentosa, I. asprella, G. jasminoides and M. candidum could be preferable for understory carbon accumulation and should be maintained or planted because of their important functions in carbon accumulation and high economic values in the young plantations of southern subtropical China

Conjugate Gradient Hard Thresholding Pursuit Algorithm for Sparse Signal Recovery

We propose a new iterative greedy algorithm to reconstruct sparse signals in Compressed Sensing. The algorithm, called Conjugate Gradient Hard Thresholding Pursuit (CGHTP), is a simple combination of Hard Thresholding Pursuit (HTP) and Conjugate Gradient Iterative Hard Thresholding (CGIHT). The conjugate gradient method with a fast asymptotic convergence rate is integrated into the HTP scheme that only uses simple line search, which accelerates the convergence of the iterative process. Moreover, an adaptive step size selection strategy, which constantly shrinks the step size until a convergence criterion is met, ensures that the algorithm has a stable and fast convergence rate without choosing step size. Finally, experiments on both Gaussian-signal and real-world images demonstrate the advantages of the proposed algorithm in convergence rate and reconstruction performance