2 research outputs found
A new potential radiosensitizer- multi-walled carbon nanotubes modified by ammonium persulfate
Here we prepare carbon nanotubes modified with ammonium persulfate, very short carbon nanotubes with 50-100
nanometer length was obtained, and the higher P potential of 52 mV was detected, these supporting the successful
modification. HeLa cells were irradiated with P rays via adding or absent above functionalized carbon nanotubes (f-
WCNTs) into cell culture medium with different concentration and radiation dosage. Confocal microscopy images
and fluorescence-labeled DNA detection verified the successfully pure multi-walled carbon nanotubes (p-WCNTs)
and f-WCNTs penetrated into cells. Compared with pure radiation, by MTT test, f-WCNTs induced cell death
markedly with about 8.7 times higher than former one under little dose of radiation; meanwhile, no obvious toxicity
was observed both in p-WCNTs and f-WCNTs without of radiation exposure. We hypothesized that large amount
of hydroxyl and carbonyl organs on the surface of very short f-WCNTs changed into free radicals result from
radiations led cell damage. These implied that f-WCNTs could be regarded as a new radiosensitizer