Twisted and Nontwisted Bifurcations Induced by Diffusion

We discuss a diffusively perturbed predator-prey system. Freedman and Wolkowicz showed that the corresponding ODE can have a periodic solution that bifurcates from a homoclinic loop. When the diffusion coefficients are large, this solution represents a stable, spatially homogeneous time-periodic solution of the PDE. We show that when the diffusion coefficients become small, the spatially homogeneous periodic solution becomes unstable and bifurcates into spatially nonhomogeneous periodic solutions. The nature of the bifurcation is determined by the twistedness of an equilibrium/homoclinic bifurcation that occurs as the diffusion coefficients decrease. In the nontwisted case two spatially nonhomogeneous simple periodic solutions of equal period are generated, while in the twisted case a unique spatially nonhomogeneous double periodic solution is generated through period-doubling. Key Words: Reaction-diffusion equations; predator-prey systems; homoclinic bifurcations; periodic solutions.Comment: 42 pages in a tar.gz file. Use ``latex2e twisted.tex'' on the tex files. Hard copy of figures available on request from [email protected]

Tracking intracavernously injected adipose-derived stem cells to bone marrow.

The intracavernous (i.c.) injection of stem cells (SCs) has been shown to improve erectile function in various erectile dysfunction (ED) animal models. However, the tissue distribution of the injected cells remains unknown. In this study we tracked i.c.-injected adipose-derived stem cells (ADSCs) in various tissues. Rat paratesticular fat was processed for ADSC isolation and culture. The animals were then subject to cavernous nerve (CN) crush injury or sham operation, followed by i.c. injection of 1 million autologous or allogeneic ADSCs that were labeled with 5-ethynyl-2-deoxyuridine (EdU). Another group of rats received i.c. injection of EdU-labeled allogeneic penile smooth muscle cells (PSMCs). At 2 and 7 days post injection, penises and femoral bone marrow were processed for histological analyses. Whole femoral bone marrows were also analyzed for EdU-positive cells by flow cytometry. The results show that ADSCs exited the penis within days of i.c. injection and migrated preferentially to bone marrow. Allogenicity did not affect the bone marrow appearance of ADSCs at either 2 or 7 days, whereas CN injury reduced the number of ADSCs in bone marrow significantly at 7 but not 2 days. The significance of these results in relation to SC therapy for ED is discussed

Phase dynamics of inductively coupled intrinsic Josephson junctions and terahertz electromagnetic radiation

The Josephson effects associated with quantum tunneling of Cooper pairs manifest as nonlinear relations between the superconductivity phase difference and the bias current and voltage. Many novel phenomena appear, such as Shapiro steps in dc cuurent-voltage (IV) characteristics of a Josephson junction under microwave shining, which can be used as a voltage standard. Inversely, the Josephson effects provide a unique way to generate high-frequency electromagnetic (EM) radiation by dc bias voltage. The discovery of cuprate high-Tc superconductors accelerated the effort to develop novel source of EM waves based on a stack of atomically dense-packed intrinsic Josephson junctions (IJJs), since the large superconductivity gap covers the whole terahertz frequency band. Very recently, strong and coherent terahertz radiations have been successfully generated from a mesa structure of $\rm{Bi_2Sr_2CaCu_2O_{8+\delta}}$ single crystal which works both as the source of energy gain and as the cavity for resonance. It is then found theoretically that, due to huge inductive coupling of IJJs produced by the nanometer junction separation and the large London penetration depth of order of $\rm{\mu m}$ of the material, a novel dynamic state is stabilized in the coupled sine-Gordon system, in which $\pm \pi$ kinks in phase differences are developed responding to the standing wave of Josephson plasma and are stacked alternatively in the c-axis. This novel solution of the inductively coupled sine-Gordon equations captures the important features of experimental observations. The theory predicts an optimal radiation power larger than the one available to date by orders of magnitude, and thus suggests the technological relevance of the phenomena.Comment: review article (69 pages, 30 figures