A Hierarchical Emotion Regulated Sensorimotor Model: Case Studies

Inspired by the hierarchical cognitive architecture and the perception-action model (PAM), we propose that the internal status acts as a kind of common-coding representation which affects, mediates and even regulates the sensorimotor behaviours. These regulation can be depicted in the Bayesian framework, that is why cognitive agents are able to generate behaviours with subtle differences according to their emotion or recognize the emotion by perception. A novel recurrent neural network called recurrent neural network with parametric bias units (RNNPB) runs in three modes, constructing a two-level emotion regulated learning model, was further applied to testify this theory in two different cases.Comment: Accepted at The 5th International Conference on Data-Driven Control and Learning Systems. 201

Transition from Mott insulator to superconductor in GaNb4_{4}Se8_{8} and GaTa4_{4}Se8_{8} under high pressure

Electronic conduction in GaM$_{4}$Se$_{8}$ (M=Nb;Ta) compounds with the fcc GaMo$_{4}$S$_{8}$-type structure originates from hopping of localized unpaired electrons (S=1/2) among widely separated tetrahedral M$_{4}$ metal clusters. We show that under pressure these systems transform from Mott insulators to a metallic and superconducting state with T$_{C}$=2.9 and 5.8K at 13 and 11.5GPa for GaNb$_{4}$Se$_{8}$ and GaTa$_{4}$Se$_{8}$, respectively. The occurrence of superconductivity is shown to be connected with a pressure-induced decrease of the MSe$_{6}$ octahedral distortion and simultaneous softening of the phonon associated with MSe-bonds.Comment: 10 pages, 5 figure

Selective Segment Initialization: Exploiting NVRAM to Reduce Device Startup Latency

Abstract-We propose Selective Segment Initialization (SSI) to exploit NVRAM to reduce the device startup latency. SSI locates a kernel binary image in byte-addressable NVRAM and boots the system using this image, eliminating the need to load it from storage. SSI also eliminates the process of decompressing and relocating the OS kernel image in embedded linux system. The key technical ingredients of SSI are precisely identifying the kernel segments where contents are updated in the course of booting and selectively reloading only these sections each time the system reboots. The fresh copy of the sections can be maintained in NVRAM, NAND flash, NOR flash, etc. SSI reduced the size of the kernel binary image loaded from storage into memory by 90% and reduced the overall device startup time by 54%. This approach can be used not only for cold boot (with NVRAM) but also for warm boot, in which the contents of DRAM persist across the system restart

HetFS: A heterogeneous file system for everyone

Storage devices have been getting more and more diverse during the last decade. The advent of SSDs made it painfully clear that rotating devices, such as HDDs or magnetic tapes, were lacking in regards to response time. However, SSDs currently have a limited number of write cycles and a significantly larger price per capacity, which has prevented rotational technologies from begin abandoned. Additionally, Non-Volatile Memories (NVMs) have been lately gaining traction, offering devices that typically outperform NAND-based SSDs but exhibit a full new set of idiosyncrasies. Therefore, in order to appropriately support this diversity, intelligent mechanisms will be needed in the near-future to balance the benefits and drawbacks of each storage technology available to a system. In this paper, we present a first step towards such a mechanism called HetFS, an extension to the ZFS file system that is capable of choosing the storage device a file should be kept in according to preprogrammed filters. We introduce the prototype and show some preliminary results of the effects obtained when placing specific files into different devices.The research leading to these results has received funding from the European Community under the BIGStorage ETN (Project 642963 of the H2020-MSCA-ITN-2014), by the Spanish Ministry of Economy and Competitiveness under the TIN2015-65316 grant and by the Catalan Government under the 2014-SGR- 1051 grant. To learn more about the BigStorage project, please visit http: //bigstorage-project.eu/.Peer ReviewedPostprint (author's final draft

NEGARA VERSUS MASYARAKAT ADAT: Studi tentang Resistensi Masyarakat Adat Dhawe atas Keputusan Pemerintah Kabupaten Nagekeo tentang Alih Fungsi Lahan Mabay Kiri

Abstrak            Keputusan alih fungsi lahan oleh pemerintah daerah telah menimbulkan resistensi Masyarakat Adat Dhawe, karena dianggap telah mengabaikan keputusan yang dibuat pemerintah sebelumnya atas kepentingan masyarakat  adat. Oleh karena itu salah satu jalan yang ditempuh masyarakat adat Dhawe adalah melakukan perlawanan. Perlawanan yang dilakukan masyarakat adat diharapkan dapat direspon secara bijak oleh pemerintah setempat. Hasil penelitian dilapangan adalah Masih belum secara optimal terealisasinya hasil kesepakatan dalam mewujudkan keinginan masyarakat untuk menjadikan lahan Mbay Kiri sebagai lahan irigasi sawah, ditambah lagi dengan hasil keputusan lain oleh pemerintah dalam memfungsikan lahan Mbay Kiri ini. Optimalisasi lahan yang dilakukan oleh pihak pemerintah sampai dengan saat ini tidak terlaksana karena diantara kedua belah pihak yang bertikai belum ada kesepakatan. Dengan demikian dapat disimpulkan bahwa Keputusan Alih Fungsi Lahan Mbay kiri ini belum menjadi solusi  untuk menjadikan lahan Mbay Kiri ini sebagai keputusan yang telah dikeluarkan melihat dari hasil implementasi yang sebenarnya igasi sawah. Diharapkan kepada pihak Pemda Nagekeo untuk melakukan peninjauan kembali atas belum menunjukan perubahan positif bagi kesejahteraan masyarakat.Abstrak            Keputusan alih fungsi lahan oleh pemerintah daerah telah menimbulkan resistensi Masyarakat Adat Dhawe, karena dianggap telah mengabaikan keputusan yang dibuat pemerintah sebelumnya atas kepentingan masyarakat  adat. Oleh karena itu salah satu jalan yang ditempuh masyarakat adat Dhawe adalah melakukan perlawanan. Perlawanan yang dilakukan masyarakat adat diharapkan dapat direspon secara bijak oleh pemerintah setempat. Hasil penelitian dilapangan adalah Masih belum secara optimal terealisasinya hasil kesepakatan dalam mewujudkan keinginan masyarakat untuk menjadikan lahan Mbay Kiri sebagai lahan irigasi sawah, ditambah lagi dengan hasil keputusan lain oleh pemerintah dalam memfungsikan lahan Mbay Kiri ini. Optimalisasi lahan yang dilakukan oleh pihak pemerintah sampai dengan saat ini tidak terlaksana karena diantara kedua belah pihak yang bertikai belum ada kesepakatan. Dengan demikian dapat disimpulkan bahwa Keputusan Alih Fungsi Lahan Mbay kiri ini belum menjadi solusi  untuk menjadikan lahan Mbay Kiri ini sebagai keputusan yang telah dikeluarkan melihat dari hasil implementasi yang sebenarnya igasi sawah. Diharapkan kepada pihak Pemda Nagekeo untuk melakukan peninjauan kembali atas belum menunjukan perubahan positif bagi kesejahteraan masyarakat

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known “drivers” of human cancer and developmental overgrowth syndromes. We recently demonstrated that the "hotspot" PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In the present study, we combine high-depth transcriptomics, total proteomics and reverse-phase protein arrays to reveal potentially disease-related alterations in heterozygous cells, and to assess the contribution of activated TGFβ signalling to the stemness phenotype of homozygous PIK3CAH1047R cells. We demonstrate signalling rewiring as a function of oncogenic PI3K signalling strength, and provide experimental evidence that self-sustained stemness is causally related to enhanced autocrine NODAL/TGFβ signalling. A significant transcriptomic signature of TGFβ pathway activation in heterozygous PIK3CAH1047R was observed but was modest and was not associated with the stemness phenotype seen in homozygous mutants. Notably, the stemness gene expression in homozygous PIK3CAH1047R iPSCs was reversed by pharmacological inhibition of NODAL/TGFβ signalling, but not by pharmacological PI3Kα pathway inhibition. Altogether, this provides the first in-depth analysis of PI3K signalling in human pluripotent stem cells and directly links strong PI3K activation to developmental NODAL/TGFβ signalling. This work illustrates the importance of allele dosage and expression when artificial systems are used to model human genetic disease caused by activating PIK3CA mutations

Fault-tolerant formation driving mechanism designed for heterogeneous MAVs-UGVs groups

A fault-tolerant method for stabilization and navigation of 3D heterogeneous formations is proposed in this paper. The presented Model Predictive Control (MPC) based approach enables to deploy compact formations of closely cooperating autonomous aerial and ground robots in surveillance scenarios without the necessity of a precise external localization. Instead, the proposed method relies on a top-view visual relative localization provided by the micro aerial vehicles flying above the ground robots and on a simple yet stable visual based navigation using images from an onboard monocular camera. The MPC based schema together with a fault detection and recovery mechanism provide a robust solution applicable in complex environments with static and dynamic obstacles. The core of the proposed leader-follower based formation driving method consists in a representation of the entire 3D formation as a convex hull projected along a desired path that has to be followed by the group. Such an approach provides non-collision solution and respects requirements of the direct visibility between the team members. The uninterrupted visibility is crucial for the employed top-view localization and therefore for the stabilization of the group. The proposed formation driving method and the fault recovery mechanisms are verified by simulations and hardware experiments presented in the paper

Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations

PURPOSE: Predicting the phenotypic effects of mutations has become an important application in clinical genetic diagnostics. Computational tools evaluate the behavior of the variant over evolutionary time and assume that variations seen during the course of evolution are probably benign in humans. However, current tools do not take into account orthologous/paralogous relationships. Paralogs have dramatically different roles in Mendelian diseases. For example, whereas inactivating mutations in the NPC1 gene cause the neurodegenerative disorder Niemann-Pick C, inactivating mutations in its paralog NPC1L1 are not disease-causing and, moreover, are implicated in protection from coronary heart disease. METHODS: We identified major events in NPC1 evolution and revealed and compared orthologs and paralogs of the human NPC1 gene through phylogenetic and protein sequence analyses. We predicted whether an amino acid substitution affects protein function by reducing the organism’s fitness. RESULTS: Removing the paralogs and distant homologs improved the overall performance of categorizing disease-causing and benign amino acid substitutions. CONCLUSION: The results show that a thorough evolutionary analysis followed by identification of orthologs improves the accuracy in predicting disease-causing missense mutations. We anticipate that this approach will be used as a reference in the interpretation of variants in other genetic diseases as well. Genet Med 18 10, 1029–1036

Measurement of the Negative Muon Anomalous Magnetic Moment to 0.7 ppm

The anomalous magnetic moment of the negative muon has been measured to a precision of 0.7 parts per million (ppm) at the Brookhaven Alternating Gradient Synchrotron. This result is based on data collected in 2001, and is over an order of magnitude more precise than the previous measurement of the negative muon. The result a_mu= 11 659 214(8)(3) \times 10^{-10} (0.7 ppm), where the first uncertainty is statistical and the second is sytematic, is consistend with previous measurements of the anomaly for the positive and negative muon. The average for the muon anomaly a_{mu}(exp) = 11 659 208(6) \times 10^{-10} (0.5ppm).Comment: 4 pages, 4 figures, submitted to Physical Review Letters, revised to reflect referee comments. Text further revised to reflect additional referee comments and a corrected Fig. 3 replaces the older versio

Cellulolytic Bacteria in the foregut of the dromedary camel (Camelus dromedarius)

Foregut digesta from five feral dromedary camels were inoculated into three different enrichment media: cotton thread, filter paper, and neutral detergent fiber. A total of 283 16S rRNA gene sequences were assigned to 33 operational taxonomic units by using 99% species-level identity. LIBSHUFF revealed significant differences in the community composition across all three libraries