Targeting multiplicity: the key factor for anti-cancer nanoparticles.

International audienceIn this mini-review, we focus on different strategies to bring nanotools specifically to cancer cells. We discuss about a better targeting of tumor, combining the characteristics of tumor environment, the increase in nanoparticles life time, the biomarkers overexpressed on cancer cells and different physical methods for non invasive therapies. Here we detail the necessity of a synergy between passive and active targeting for an actual specificity of cancer cells

Anytime and efficient coalition formation with spatial and temporal constraints

The Coalition Formation with Spatial and Temporal constraints Problem (CFSTP) is a multi-agent task scheduling problem where the tasks are spatially distributed, with deadlines and workloads, and the number of agents is typically much smaller than the number of tasks, thus the agents have to form coalitions in order to maximise the number of completed tasks. The current state-of-the-art CFSTP solver, the Coalition Formation with Look-Ahead (CFLA) algorithm, has two main limitations. First, its time complexity is exponential with the number of agents. Second, as we show, its look-ahead technique is not effective in real-world scenarios, such as open multi-agent systems, where new tasks can appear at any time. In this work, we study its design and define an extension, called Coalition Formation with Improved Look-Ahead (CFLA2), which achieves better performance. Since we cannot eliminate the limitations of CFLA in CFLA2, we also develop a novel algorithm to solve the CFSTP, the first to be anytime, efficient and with provable guarantees, called Cluster-based Coalition Formation (CCF). We empirically show that, in settings where the look-ahead technique is highly effective, CCF completes up to 30% (resp. 10%) more tasks than CFLA (resp. CFLA2) while being up to four orders of magnitude faster. Our results affirm CCF as the new state-of-the-art algorithm to solve the CFSTP.Comment: 18 pages, 1 figur