13 research outputs found

    Can It Work for Us Too? Results from Using West Point’s Fundamentals of Engineering Mechanics and Design Course Redesign

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    At the 2017 ASEE National Conference and Exhibition two papers from the US Military Academy (one in the Mechanics Division and one in the Civil Engineering Division) detailed a redesign of their initial mechanics sequence and the introduction of Inquiry Based Learning Activities. The authors of those papers extended an offer to share details and materials of their course redesign and associated lesson activities. The authors of this paper took them up on that offer and in the Fall of 2017 implemented the changes proposed at the US Military Academy at their institution. The question this paper strives to answer is, can a similar course redesign produce similar results at an institution, that in many respects is very different from the US Military Academy; essentially is the West Point redesign reproducible and the results replicable and if so under what conditions? This paper will strive to use many of the same measures from the original paper in the analysis of the success or failure of the implementation. The paper will also examine and document the differences between the students and institutions. It will then note differences in the administration of the course, changes made, and conduct of the course, to include number of instructors, sections, section size, group size and the demographic make-up of students in the course and list the effect of the differences discovered at this time. Finally, considering differences and similarities, the paper will analyze and capture the results and the effects of the two applications of the course redesign to come up with an answer to the research question

    The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication

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    The origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where its primary function is to recruit silent information regulator (SIR) proteins to establish transcriptional silencing. Indeed, silencers function poorly as chromosomal origins. Several genetic, molecular, and biochemical studies of HMR-E have led to a model proposing that when ORC becomes limiting in the cell (such as in the orc2-1 mutant) only sites that bind ORC tightly (such as HMR-E) remain fully occupied by ORC, while lower affinity sites, including many origins, lose ORC occupancy. Since HMR-E possessed a unique non-replication function, we reasoned that other tight sites might reveal novel functions for ORC on chromosomes. Therefore, we comprehensively determined ORC “affinity” genome-wide by performing an ORC ChIP–on–chip in ORC2 and orc2-1 strains. Here we describe a novel group of orc2-1–resistant ORC–interacting chromosomal sites (ORF–ORC sites) that did not function as replication origins or silencers. Instead, ORF–ORC sites were comprised of protein-coding regions of highly transcribed metabolic genes. In contrast to the ORC–silencer paradigm, transcriptional activation promoted ORC association with these genes. Remarkably, ORF–ORC genes were enriched in proximity to origins of replication and, in several instances, were transcriptionally regulated by these origins. Taken together, these results suggest a surprising connection among ORC, replication origins, and cellular metabolism

    Science overview of the Europa Clipper mission

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    The goal of NASA’s Europa Clipper mission is to assess the habitability of Jupiter’s moon Europa. After entering Jupiter orbit in 2030, the flight system will collect science data while flying past Europa 49 times at typical closest approach distances of 25–100 km. The mission’s objectives are to investigate Europa’s interior (ice shell and ocean), composition, and geology; the mission will also search for and characterize any current activity including possible plumes. The science objectives will be accomplished with a payload consisting of remote sensing and in-situ instruments. Remote sensing investigations cover the ultraviolet, visible, near infrared, and thermal infrared wavelength ranges of the electromagnetic spectrum, as well as an ice-penetrating radar. In-situ investigations measure the magnetic field, dust grains, neutral gas, and plasma surrounding Europa. Gravity science will be achieved using the telecommunication system, and a radiation monitoring engineering subsystem will provide complementary science data. The flight system is designed to enable all science instruments to operate and gather data simultaneously. Mission planning and operations are guided by scientific requirements and observation strategies, while appropriate updates to the plan will be made tactically as the instruments and Europa are characterized and discoveries emerge. Following collection and validation, all science data will be archived in NASA’s Planetary Data System. Communication, data sharing, and publication policies promote visibility, collaboration, and mutual interdependence across the full Europa Clipper science team, to best achieve the interdisciplinary science necessary to understand Europa
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