The global status and hotspots of research in the field of trans-oral endoscopic thyroidectomy (TOET) from 2008 to 2022

PurposeIn this study, the aim was to comprehensively analyze the current status, hotspots, and trends of trans-oral endoscopic thyroidectomy (TOET) through bibliometric analysis and by presenting the field atlas.MethodsWeb of Science Core Collection database was adopted to screen studies regarding TOET published between January 1, 2008 and August 1, 2022. The evaluation covered the criteria total number of studies, keywords, and contributions from countries/regions, institutions, journals, and authors.ResultsA total of 229 studies were covered. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES is the largest publication in the field of TOET. The three countries that contributed the most studies were Korea, China, and the USA. The most frequently occurring core keywords in the field of TOET are vestibular approach, outcomes, experience, safety, robotic thyroidectomy, scar, video-assisted thyroidectomy and quality-of-life. The seven clusters were generated in this study: intraoperative monitoring of the laryngeal return nerve (# 0), learning curve (# 1), postoperative quality of life (# 2), central lymph node dissection and safety (# 3), complications (# 4), minimally invasive surgery (# 5), and robotic surgery (# 6).ConclusionThe main research topics in the field of TOET place focuses on learning curves, laryngeal nerve monitoring, carbon dioxide gas bolus, chin nerve injury, surgical complications, and surgical safety. In the future, more academics will focus on the safety of the procedure and reducing complications.

PGC1α: an emerging therapeutic target for chemotherapy-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN)-mediated paresthesias are a common complication in cancer patients undergoing chemotherapy. There are currently no treatments available to prevent or reverse CIPN. Therefore, new therapeutic targets are urgently needed to develop more effective analgesics. However, the pathogenesis of CIPN remains unclear, and the prevention and treatment strategies of CIPN are still unresolved issues in medicine. More and more studies have demonstrated that mitochondrial dysfunction has become a major factor in promoting the development and maintenance of CIPN, and peroxisome proliferator-activated receptor gamma (PPARγ) coactivator 1α (PGC1α) plays a significant role in maintaining the mitochondrial function, protecting peripheral nerves, and alleviating CIPN. In this review, we highlight the core role of PGC1α in regulating oxidative stress and maintaining normal mitochondrial function and summarize recent advances in its therapeutic effects and mechanisms in CIPN and other forms of peripheral neuropathy. Emerging studies suggest that PGC1α activation may positively impact CIPN mitigation by modulating oxidative stress, mitochondrial dysfunction, and inflammation. Therefore, novel therapeutic strategies targeting PGC1α could be a potential therapeutic target in CIPN

Disposal Situation of Sewage Sludge from Municipal Wastewater Treatment Plants (WWTPs) and Assessment of the Ecological Risk of Heavy Metals for Its Land Use in Shanxi, China

Land use of sewage sludge is the primary disposal method in Shanxi, accounting for 42.66% of all. To determine the ecological risk of heavy metals in sewage sludge, contents of seven heavy metals in sewage sludge from 9 municipal waste water treatment plants (WWTPs) that had the highest application for land use were determined. The order of the measured concentrations was: Zn > Cr > Cu > Ni > Pb > As > Cd, and all heavy metals contents were within the threshold limit values of the Chinese Control Standards for Pollutants in Sludge from Agriculture Use (GB4284-84). Four indices were used to assess the pollution and the ecological risk of heavy metals. By the mean values of the geoaccumulation index (Igeo), heavy metals were ranked in the following order: Cd > Zn > Cu > As > Cr > Ni > Pb. The values showed that the pollution of Zn in station 3 and Cd in station 1, 2, 3, 4, 8 and 9 were heavily; Cu in station 8 and 9, Zn in station 1, 2, 4, 8 and 9 and Cd in station 5 and 7 were moderately to heavily, and the accumulation of other heavy metals were not significant. The single-factor pollution index (PI) suggested that none of the stations had heavy metals contamination, except for Cu in station 9, Zn in station 3 and 8, and Cd in station 1 and 9, which were at a moderate level. According to the results of the Nemerow’s synthetic pollution index (PN), sewage sludge from all stations was safe for land use with respect to heavy metals contamination, except for stations 3, 8 and 9, which were at the warning line. The monomial potential ecological risk coefficient (Eri) revealed that heavy metals ecological risks in most stations were low. However, station 9 had a moderate risk for Cu; station 6 had a moderate risk, stations 5 and 7 had high risk, other stations had very high risk for Cd. According to the results of the potential ecological risk index (RI), station 1, 8 and 9 had high risk; station 2, 3, 4, 5 and 7 had a moderate risk, and station 6 had a low risk. The preliminary results indicated that the potential risk of land exposure to heavy metals in sewage sludge was relatively low, with Zn and Cd as the main contributor to the ecological risk for the applying of sewage sludge on land. Additionally, stations 3, 8 and 9 require more attention regarding the land applications related to heavy metals pollution

Comparison of Health Risk Assessments of Heavy Metals and As in Sewage Sludge from Wastewater Treatment Plants (WWTPs) for Adults and Children in the Urban District of Taiyuan, China

Abstract: To compare the human health risk of heavy metals and As in sewage sludge between adults and children, samples were collected from five wastewater treatment plants (WWTPs) located in the urban district of Taiyuan, the capital of Shanxi. Heavy metals and As in sewage sludge can be ranked according to the mean concentration in the following order: Cu > Cr > Zn > Pb > As > Hg > Cd. Compared with the concentration limit set by different countries, the heavy metals contents in sewage sludge were all within the standard limits, except for the content of As, which was higher than the threshold limit established by Canada. A health risk assessment recommended by the United States Environmental Protection Agency (USEPA) was used to compare the non-cancer risk and cancer risk between adults and children. Based on the mean and 95% upper confidence limit (UCL) of the average daily dose (ADD), heavy metals and As can be ranked in the order of Cu > Cr > Zn > Pb > As > Hg > Cd for adults, and Cu > Cr > Zn > Pb > Hg > As > Cd for children. Moreover, results of ADDingest and ADDinhale indicated that ingestion was the main pathway for heavy metals and As exposure for both adults and children, and the sum of ADD implied that the exposure to all heavy metals and As for children was 8.65 and 9.93 times higher, respectively, than that for adults according to the mean and 95% UCL. For the non-carcinogenic risk, according to the hazard quotient (HQ), the risk of Cu, Hg and Cr was higher than the risk of Zn and Pb. The hazard index (HI) for adults was 0.144 and 0.208 for the mean and 95% UCL, which was less than the limit value of 1; for children, the HI was 1.26 and 2.25, which is higher than the limit value of 1. This result indicated that children had non-carcinogenic risk, but adults did not. Furthermore, ingestion was the main pathway for non-carcinogenic risk exposure by the HQingest and HQinhale. For the carcinogenic risk, Cd and As were classified as carcinogenic pollutants. The values of RISK for the mean and 95% UCL for adults and children all exceeded the limit value of 1 × 10−5, which implied that adults and children had a carcinogenic risk, and this risk was higher for children than for adults. The results of RISK for As and Cd implied that As was the main pollutant for carcinogenic risk. Moreover, the results of RISKingest and RISKinhale indicated that ingestion was the main pathway. Uncertainty analysis was performed, and the risk ranges of it were greater than certainty analysis, which implied that uncertainty analysis was more conservative than certainty analysis. A comparison of the non-carcinogenic risk and carcinogenic risk for adults and children indicated that children were more sensitive and vulnerable than adults when exposed to the same pollutant in the environment

Xiaolingtong versus 3G in China: Which will be the winner?

Xiaolingtong (XLT), a new type of mobile phone system based on PHS technology for wireless access of fixed-line telephone networks, has grown very rapidly in China. However, there are many doubts about the future of XLT once 3G (the third generation of mobile communication) is finally employed. This paper proposes a theoretical framework to assess and compare XLT and 3G from four perspectives: technology, market demand, business models and government policy. It concludes that XLT and 3G will coexist with existing 2G/2.5G mobile communication networks for a considerable period of time. With service collaboration and integration, the coexistence of both of these technologies can enhance China's mobile communication infrastructure and support the growth of mobile commerce.Mobile communication Technology assessment Business model Government policy PHS 3G 2G/2.5G

Evaluation and Source Apportionment of Heavy Metals (HMs) in Sewage Sludge of Municipal Wastewater Treatment Plants (WWTPs) in Shanxi, China

Heavy metals (HMs) in sewage sludge have become the crucial limiting factors for land use application. Samples were collected and analyzed from 32 waste water treatment plants (WWTPs) in the Shanxi Province, China. HM levels in sewage sludge were assessed. The multivariate statistical method principal component analysis (PCA) was applied to identify the sources of HMs in sewage sludge. HM pollution classes by geochemical accumulation index Igeo and correlation analyses between HMs were also conducted. HMs were arranged in the following decreasing order of mean concentration: Zn > Cu > Cr > Pb > As > Hg > Cd; the maximum concentrations of all HMs were within the limit of maximum content permitted by Chinese discharge standard. Igeo classes of HMs pollution in order from most polluted to least were: Cu and Hg pollution were the highest; Cd and Cr pollution were moderate; Zn, As and Pb pollution were the least. Sources of HM contamination in sewage sludge were identified as three components. The primary contaminant source accounting for 35.7% of the total variance was identified as smelting industry, coking plant and traffic sources; the second source accounting for 29.0% of the total variance was distinguished as household and water supply pollution; the smallest of the three sources accounting for 16.2% of the total variance was defined as special industries such as leather tanning, textile manufacturing and chemical processing industries. Source apportionment of HMs in sewage sludge can control HM contamination through suggesting improvements in government policies and industrial processes

Pan‐cancer analyses reveal multi‐omic signatures and clinical implementations of the forkhead‐box gene family

Abstract Background Forkhead box (FOX) proteins belong to one of the largest transcription factor families and play crucial roles in the initiation and progression of cancer. Prior research has linked several FOX genes, such as FOXA1 and FOXM1, to the crucial process of carcinogenesis. However, the overall picture of FOX gene family across human cancers is far from clear. Methods To investigate the broad molecular signatures of the FOX gene family, we conducted study on multi‐omics data (including genomics, epigenomics and transcriptomics) from over 11,000 patients with 33 different types of human cancers. Results Pan‐cancer analysis reveals that FOX gene mutations were found in 17.4% of tumor patients with a substantial cancer type‐dependent pattern. Additionally, high expression heterogeneity of FOX genes across cancer types was discovered, which can be partially attributed to the genomic or epigenomic alteration. Co‐expression network analysis reveals that FOX genes may exert functions by regulating the expression of both their own and target genes. For a clinical standpoint, we provided 103 FOX gene‐drug target‐drug predictions and found FOX gene expression have potential survival predictive value. All of the results have been included in the FOX2Cancer database, which is freely accessible at http://hainmu‐biobigdata.com/FOX2Cancer. Conclusion Our findings may provide a better understanding of roles FOX genes played in the development of tumors, and help to offer new avenues for uncovering tumorigenesis and unprecedented therapeutic targets

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www.elsevierbusinessandmanagement.com/locate/telpol Xiaolingtong versus 3G in China: Which will be the winner