Numerical Investigation on the Dynamic Flow Pattern in a New Wastewater Treatment System

Currently, industries seek to optimize the development of technology from energy-saving, economic, and environmental perspectives. Dissolved air flotation (DAF) is one of the most effective wastewater treatment systems. However, it requires considerable energy and causes significant operating costs. A recently emerged application of using fluidic oscillators (FOs) to generate microbubbles has attracted extensive attention, as it consumes much less energy and has proven to be a more energy-efficient technique. In this article, a microbubble generator based on FOs is introduced into the flotation tank, and an energy-saving water treatment system, namely fluidic air flotation (FAF), is presented. Using the computational fluid dynamics (CFD) method, the flow pattern of the FAF is investigated. It is observed that FAF generates a dynamic flow pattern, which is beneficial for bubble removal. At the upper part of the separation zone, the flow pattern exhibits a wavy shape. The flow pattern at the lower part switches between clockwise and counterclockwise. The air distribution of the separation zone is also studied. It is found that the height of the “white water” zone almost linearly decreases with the increase in bubble diameter and diffuser size. FAF consumes almost no energy and occupies a small area, and it is expected to provide a promising solution to develop a new generation of the wastewater treatment system

PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers

LncRNAs are involved in the occurrence and progressions of multiple cancers. Emerging evidence has shown that PCAT6, a newly discovered carcinogenic lncRNA, is abnormally elevated in various human malignant tumors. Until now, PCAT6 has been found to sponge various miRNAs to activate the signaling pathways, which further affects tumor cell proliferation, migration, invasion, cycle, apoptosis, radioresistance, and chemoresistance. Moreover, PCAT6 has been shown to exert biological functions beyond ceRNAs. In this review, we summarize the biological characteristics of PCAT6 in a variety of human malignancies and describe the biological mechanisms by which PCAT6 can facilitate tumor progression. Finally, we discuss its diagnostic and prognostic values and clinical applications in various human malignancies

Photo-thermal coupling to enhance CO2 hydrogenation toward CH4 over Ru/MnO/Mn3O4

Abstract Upcycling of CO2 into fuels by virtually unlimited solar energy provides an ultimate solution for addressing the substantial challenges of energy crisis and climate change. In this work, we report an efficient nanostructured Ru/MnOx catalyst composed of well-defined Ru/MnO/Mn3O4 for photo-thermal catalytic CO2 hydrogenation to CH4, which is the result of a combination of external heating and irradiation. Remarkably, under relatively mild conditions of 200 °C, a considerable CH4 production rate of 166.7 mmol g−1 h−1 was achieved with a superior selectivity of 99.5% at CO2 conversion of 66.8%. The correlative spectroscopic and theoretical investigations suggest that the yield of CH4 is enhanced by coordinating photon energy with thermal energy to reduce the activation energy of reaction and promote formation of key intermediate COOH* species over the catalyst. This work opens up a new strategy for CO2 hydrogenation toward CH4

Load-induced dynamical transitions at graphene interfaces

The structural superlubricity (SSL), a state of near-zero friction between two contacted solid surfaces, has been attracting rapidly increasing research interest since it was realized in microscale graphite in 2012. An obvious question concerns the implications of SSL for micro- and nanoscale devices such as actuators. The simplest actuators are based on the application of a normal load; here we show that this leads to remarkable dynamical phenomena in microscale graphite mesas. Under an increasing normal load, we observe mechanical instabilities leading to dynamical states, the first where the loaded mesa suddenly ejects a thin flake and the second characterized by peculiar oscillations, during which a flake repeatedly pops out of the mesa and retracts back. The measured ejection speeds are extraordinarily high (maximum of 294 m/s), and correspond to ultrahigh accelerations (maximum of 1.1×1010 m/s2). These observations are rationalized using a simple model, which takes into account SSL of graphite contacts and sample microstructure and considers a competition between the elastic and interfacial energies that defines the dynamical phase diagram of the system. Analyzing the observed flake ejection and oscillations, we conclude that our system exhibits a high speed in SSL, a low friction coefficient of 3.6×10−6, and a high quality factor of 3×107 compared with what has been reported in literature. Our experimental discoveries and theoretical findings suggest a route for development of SSL-based devices such as high-frequency oscillators with ultrahigh quality factors and optomechanical switches, where retractable or oscillating mirrors are requiredISSN:0027-8424ISSN:1091-649

Mechanisms of Oxidase and Superoxide Dismutation-like Activities of Gold, Silver, Platinum, and Palladium, and Their Alloys: A General Way to the Activation of Molecular Oxygen

Metal and alloy nanomaterials have intriguing oxidase- and superoxide dismutation-like (SOD-like) activities. However, origins of these activities remain to be studied. Using density functional theory (DFT) calculations, we investigate mechanisms of oxidase- and SOD-like properties for metals Au, Ag, Pd and Pt and alloys Au_4–<i>x</i>M_<i>x</i> (<i>x</i> = 1, 2, 3; M = Ag, Pd, Pt). We find that the simple reactiondissociation of O₂supported on metal surfaces can profoundly account for the oxidase-like activities of the metals. The activation (<i>E</i>_act) and reaction energies (<i>E</i>_r) calculated by DFT can be used to effectively predict the activity. As verification, the calculated activity orders for series of metal and alloy nanomaterials are in excellent agreement with those obtained by experiments. Briefly, the activity is critically dependent on two factors, metal compositions and exposed facets. On the basis of these results, an energy-based model is proposed to account for the activation of molecular oxygen. As for SOD-like activities, the mechanisms mainly consist of protonation of O₂^•– and adsorption and rearrangement of HO₂^• on metal surfaces. Our results provide atomistic-level insights into the oxidase- and SOD-like activities of metals and pave a way to the rational design of mimetic enzymes based on metal nanomaterials. Especially, the O₂ dissociative adsorption mechanism will serve as a general way to the activation of molecular oxygen by nanosurfaces and help understand the catalytic role of nanomaterials as pro-oxidants and antioxidants