Cervical HPV infection in Yueyang, China: a cross-sectional study of 125,604 women from 2019 to 2022

ObjectiveHuman papillomavirus (HPV) infection is currently the main cause of cervical cancer and precancerous lesions in women. The aim of this study was to investigate the epidemiological characteristics of HPV genotypes among women in Yueyang city and to provide a basis for the prevention and treatment of cervical cancer in this city.MethodsA cross-sectional study was conducted on 125,604 women who had received treatment from eight hospitals in Yueyang city from September 2019 to September 2022. Analysis of the prevalence of HPV in patients.ResultsThe prevalence of HPV was 20.5% (95%CI: 20.2–20.7%), of which the high-risk type (HR-HPV) accounted for 17.5% (95%CI: 17.3–17.7%) and the low-risk type (LR-HPV) accounted for 5.0% (95%CI: 4.9–5.1%). Among the HR-HPV subtypes, the top five in prevalence, from the highest to the lowest, were HPV52 (5.1%), HPV16(2.7%), HPV58 (2.6%), HPV53 (2.4%), and HPV51 (1.7%). The main LR-HPV infection types were HPV81 (2,676 cases, OR = 2.1%; 95%CI, 2.0–2.1%). Among the infected patients, 19,203 cases (OR = 74.3%; 95%CI, 73.8–74.9%) had a single subtype, 4,673 cases (OR = 18.1%; 95%CI, 17.6–18.6%) had two subtypes, and 1957 cases (OR = 7.6%; 95%CI, 7.3–7.9%) had three or more subtypes. HPV prevalence is highest among women <25 years, 55–64 years and ≥ 65 years of age.ConclusionThe prevalence of HPV in women in Yueyang city was 20.5%, with HR-HPV being dominant. As women aged <25 years, 55–64 years, and ≥ 65 years are at a relatively higher risk, more attention should be paid to them for prevention and control of HPV infections

Tensile behavior of strain-hardening cementitious composites after self-healing based on a novel fiber-bridging model considering preloading and reloading

The self-healing of strain-hardening cementitious composites (SHCCs) causes the recovery of the debonded fiber-to-matrix interface by the products of autogenous healing (mainly calcium carbonates). The recovery of chemical bond Gd has been detected in the reactive magnesia cement (RMC)-based SHCC (SHMC), and the recovery of frictional bond τ0 has been detected in both SHMCs and normal SHCCs. While these phenomena can significantly alter the fiber-bridging σ-w relationship in SHCCs, they have not been quantified in any existing analytical models. In this work, we present a new fiber-bridging model that captures the effect of self-healing of RMC-based SHCC. On the single-fiber level, the debonding and slip-hardening of the fiber-to-matrix interface induced by a tensile preloading as well as the recovery of the interface properties by self-healing are coherently quantified in a clear kinetic process. On the fiber-bridging level, the tensile stress vs. crack width curve is formed by summing individual fibers’ tensile load vs. displacement relationship. The modeling results can well capture the fiber-bridging behavior of the self-healed SHCC specimens. Further, a parametric study is conducted to investigate the tensile behavior of SHCC after self-healing. The effects of preloading levels, recovered τ0, and fiber strength are discussed

Back Frame Optimization of a Large Radio Telescope Based on Force Cone Method

A new research perspective is proposed to optimize the topology of truss structure by force cone method, which involves force cone drawing rules and growth rules. Through the comparison with the mature variable density topology optimization method, the effectiveness of force cone method is verified. This kind of new method is simple and easy to understand (no need to master complex structural optimization design theory). Besides, it is time-saving in finite element calculations, and can obtain an optimized truss layout easily. By drawing the force cone, its application on a large radio telescope's back frame structure shows that, compared with the existing one in terms of structural stiffness, Root Mean Square (RMS) precision, and beam stress distribution, the optimized back frame using the force cone method has higher stiffness, better RMS, more uniform stress, and lighter weight

Karyotype Analysis of Gazania rigens Varieties

For studying species origin, systematic evolution and phylogenetic relationship of Gazania rigens, four different G. rigens varieties, with different flower colors, were subjected to chromosome karyotype analysis. The somatic chromosome number in three varieties ‘Hongwen’, ‘Xingbai’ and ‘Richu’ was 2n = 10, while in ‘Zhongguo Xunzhangju’ it was 2n = 20. We speculate that the cardinal number of chromosomes in G. rigens plants is x = 5, in which case ‘Zhongguo Xunzhangju’ is a tetraploid. The karyotype formulae of ‘Hongwen’, ‘Xingbai’ and ‘Richu’ were 2n = 8m + 2sm, 2n = 8m  + 2sm and 2n = 10m respectively. The karyotype formula of ‘Zhongguo Xunzhangju’ was 2n = 18m + 2sm. The asymmetrical karyotype coefficients of the four G. rigens varieties ranged from 53.80% to 58.84%. Only ‘Richu’ had a ‘1A’ karyotype, while the others were relatively symmetric ‘2A’. Karyotype analysis indicates that the three introduced varieties have a close genetic relationship

Exosomal miR-125a-5p regulates T lymphocyte subsets to promote silica-induced pulmonary fibrosis by targeting TRAF6

Silicosis caused by long-term inhalation of crystalline silica during occupational activities seriously threatens the health of occupational populations. Imbalances in T helper 1(Th1), Th2, Th17, and regulatory T cells (Tregs) promote the development of pulmonary silicosis. Exosomes and their contents, especially microRNAs (miRNAs), represent a new type of intercellular signal transmission mediator related to various diseases including pulmonary fibrosis. However, whether exosomal miRNAs can affect the progression of silicosis by regulating T cell differentiation remains to be determined. To test this hypothesis, we established a miR-125a-5p antagomir mouse model and examined changes in miR-125a-5p levels and T cell subtypes. We found that miR-125a-5p levels were increased in lung tissues and serum exosomes in the silica group at 7 days and 28 days. Downregulation of miR-125a-5p attenuated α-smooth muscle actin (α-SMA), collagen I, fibronectin, p-p65, and p-inhibitor of nuclear factor kappa B (NF-κB) kinase (IKK) protein expression, while tumor necrosis factor receptor-associated factor 6 (TRAF6) and p-inhibitor of κBα (IKBα) expression were increased. MiR-125a-5p anta-miR treatment contributes to the maintenance of Th1/Th2 balance during the progression of pulmonary fibrosis. Our findings indicated that knockdown miR-125a-5p could regulate T lymphocyte subsets and significantly reduce pulmonary fibrosis by targeting TRAF6