164 research outputs found
When chatbots fail: exploring user coping following a chatbots-induced service failure
PurposeWhile the proliferation of chatbots allows companies to connect with their customers in a cost- and time-efficient manner, it is not deniable that they quite often fail expectations and may even pose negative impacts on user experience. The purpose of the study is to empirically explore the negative user experience with chatbots and understand how users respond to service failure caused by chatbots.Design/methodology/approachThis study adopts a qualitative research method and conducts thematic analysis of 23 interview transcripts.FindingsIt identifies common areas where chatbots fail user expectations and cause service failure. These include their inability to comprehend and provide information, over-enquiry of personal or sensitive information, fake humanity, poor integration with human agents, and their inability to solve complicated user queries. Negative emotions such as anger, frustration, betrayal and passive defeat were experienced by participants when they interacted with chatbots. We also reveal four coping strategies users employ following a chatbots-induced failure: expressive support seeking, active coping, acceptance and withdrawal.Originality/valueOur study extends our current understanding of human-chatbot interactions and provides significant managerial implications. It highlights the importance for organizations to re-consider the role of their chatbots in user interactions and balance the use of human and chatbots in the service context, particularly in customer service interactions that involve resolving complex issues or handling non-routinized tasks
Opinion:Can working abroad ever be worthwhile?
Despite assumptions of automatic benefits, sending people abroad can sometimes be bad for business, while working abroad can be as much of a pain, as a perk or privilege.Over the last 3 years, we have managed and participated in a major international staff exchange programme supporting research and innovation, funded by the European Commission. A consortium of 16 partner organizations of varying size, in different industries and across five countries in Europe and Asia undertook to complete 270 months of international secondment between them.The results have been overwhelmingly positive and successful: new and fruitful relationships between individuals and institutions, a diverse network growing in size and stability, increasing confidence, creativity and innovation within the project, a rapidly developing international profile and significant new skills sets, international experience and effectiveness for all involved. We have navigated stormy geopolitical waters involving Brexit and US-intra-Korean relations. The development of such capacity is a key aim of our project.However, we have arguably learned more from our failures than our success. In this opinion piece we want to take the rare opportunity reflect on the mistakes we have made and how we rectified them, recovered and thrived. By the end of our staff exchange project, we believe we will have perfected the creation of value from international mobility and everyone can learn from our experience and the solutions we have developed
Dynamics of the Energy Relaxation and Decoherence of a Photon-Atom Bound State in an Anisotropic Photonic Crystal
An atom embedded inside photonic crystals can form a photon-atom bound state if the emission frequency of the excited atom is lying inside the photonic-band gap of photonic crystals. We studied the dynamics of the energy relaxation and decoherence of a QPAB, qubit made by a photon-atom bound state in photonic crystals. Dynamics of these measurements are solved analytically through the fractional calculus which has been shown to be appropriate mathematical method for the optical systems with non-Markovian dynamics. From these dynamics, we find that the losses of energy, coherence, and information of a QPAB are inhibited. As compared with those qubits without forming photon-atom bound states, the energy relaxation and decoherence rates of these QPABs are strongly suppressed. Other systems suitable for realizing these properties are discussed
Responding to the UN sustainability goals in transdisciplinary partnership through network action learning
The global water crisis, an enormous concern according to the World Economic Forum, poses a significant challenge to long-term sustainability, exacerbated by the high energy demand associated with water supply and treatment. As the renewable energy sector grows, the need for green technologies to support the water-energy nexus becomes evident. However, mere technological advancements are insufficient to address complex water-related challenges. This paper presents a transdisciplinary collaborative effort involving engineers, geographers, management researchers, and environmentalists working with practitioners in a cross-border network. The study explores through action learning research how, in a transdisciplinary partnership, network action learning influences the exploration and implementation of novel green technology and the development of innovation capabilities. The research is structured around three themes: green technology platforms, policy support and guidance, and dissemination and collaboration. It identifies the factors impacting technology exploration and application and how concurrently green innovation capabilities are developed. The study emphasizes the significance of transdisciplinary collaboration and offers valuable insights into addressing UN Sustainability Goals related to clean water, sustainable industry, and partnerships. It contributes to innovation capability theory and provides practical guidance to researchers, practitioners, and policymakers, emphasizing the need for holistic approaches to address the water-energy crisis and achieve sustainable development
Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation
<p>Abstract</p> <p>Background</p> <p>The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy.</p> <p>Methods</p> <p>Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients were treated with IMRT with simultaneous integrated boost technique. Acute and late toxicities were recorded based on CTCAE 3.0 (Common Terminology Criteria for Adverse Events).</p> <p>Results</p> <p>The median follow-up time for survivors was 53.0 months (range 36-82 months). The initial complete response rate was 85.2%, with a laryngeal preservation rate of 63.0%. The 5-year functional laryngeal, local-regional control, disease-free and overall survival rates were 59.7%, 63.3%, 51.0% and 34.8%, respectively. The most common greater than or equal to grade 3 acute and late effects were dysphagia (63.0%, 17 of 27 patients) and laryngeal stricture (18.5%, 5 of 27 patients), respectively. Patients belonging to the high risk group showed significantly higher risk of tracheostomy compared to the low risk group (p = 0.014).</p> <p>Conclusions</p> <p>After long-term follow-up, our results confirmed that patients with hypopharyngeal carcinoma treated with IMRT concurrent with platinum-based chemotherapy attain high functional laryngeal and local-regional control survival rates. However, the late effect of laryngeal stricture remains a problem, particularly for high risk group patients.</p
Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models
IntroductionArsenic (As) exposure is associated with lung toxicity and we aim to investigate the effects of arsenic exposure on lung fibrotic changes.MethodsParticipants (n= 976) enrolled via a general health survey underwent chest low-dose computed tomography (LDCT), spirometry forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and urinary arsenic examination during 2016 and 2018. Lung fibrotic changes from LDCT were defined. AsLtoL, low arsenic levels in both 2016 and 2018; AsLtoH, low arsenic in 2016 but high levels in 2018; AsHtoL, high arsenic in 2016 but low levels in 2018; AsHtoH, high arsenic levels in both 2016 and 2018. Mice exposed to 0. 0.2mg/L, 2 mg/L, 50 mg/L of sodium arsenite (NaAsO2) through drinking water for 12 weeks and 24 weeks were applied for histological analysis. Cultured lung epithelial cells were exposed to NaAsO2 and the mesenchymal changes were examined.ResultsAsHtoH increased the risk (OR= 1.65, 95% CI 1.10, 2.49) of Lung fibrotic positive to positive (reference: Lung fibrotic negative to negative) compared with AsLtoL. Moreover, the predicted mean of FVC and FEV1 in AsHtoH (−0.09 units, 95% CI: −0.27, −0.09; −0.09 units, 95% CI: −0.17, −0.01) and AsLtoH (−0.13 units, 95% CI: −0.30, −0.10; −0.13 units, 95% CI: −0.22, −0.04) was significantly lower than ASLtoL. Significant lung fibrotic changes including the increase of the alveolar septum thickness and collagen fiber deposition were observed upon 2 mg/L NaAsO2 treatment for 12 weeks, and the damage was dose- and time-dependent. In vitro, sodium arsenite treatment promotes the epithelial-mesenchymal transition (EMT)-like changes of the normal human bronchial epithelial cells, including upregulation of several fibrotic and mesenchymal markers (fibronectin, MMP-2, and Snail) and cell migration. Inhibition of reactive oxygen species (ROS) and MMP-2 impaired the arsenic-induced EMT changes. Administration of a flavonoid, apigenin, inhibited EMT in vitro and pulmonary damages in vivo with the reduction of mesenchymal markers.Discussionwe demonstrated that continued exposure to arsenic causes lung fibrosis in humans and mice. Targeting lung epithelial cells EMT is effective on the development of therapeutic strategy. Apigenin is effective in the inhibition of arsenic-induced pulmonary fibrosis and EMT
Trypsin-induced proteome alteration during cell subculture in mammalian cells
<p>Abstract</p> <p>Background</p> <p>It is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to the proteolytic activity of trypsin, cell surface proteins are often cleaved, which leads to dysregulation of the cell functions.</p> <p>Methods</p> <p>In this study, a triplicate 2D-DIGE strategy has been performed to monitor trypsin-induced proteome alterations. The differentially expressed spots were identified by MALDI-TOF MS and validated by immunoblotting.</p> <p>Results</p> <p>36 proteins are found to be differentially expressed in cells treated with trypsin, and proteins that are known to regulate cell metabolism, growth regulation, mitochondrial electron transportation and cell adhesion are down-regulated and proteins that regulate cell apoptosis are up-regulated after trypsin treatment. Further study shows that bcl-2 is down-regulated, p53 and p21 are both up-regulated after trypsinization.</p> <p>Conclusions</p> <p>In summary, this is the first report that uses the proteomic approach to thoroughly study trypsin-induced cell physiological changes and provides researchers in carrying out their experimental design.</p
Managing a mega-project to explore and enhance careers: insights from Global Entrepreneurial Talent Management 3
Contemporary careers are changing and face many challenges. This creates a need for innovative cross-cultural and multidisciplinary research. In this chapter, twenty-three participants in a European/South Korean research mega-project provide an overview of their diverse experiences of trans-national, trans-sectoral, and trans-generational work. First, the project’s architects explore the context and rationale in five countries, selection of partners, securing funding and the underpinning principles of ‘strategic entrepreneurship’ and ‘multi-sociation’. Key workstream leaders then outline the project content, including diplomacy in research design, reflecting gender, ensuring impact, capturing learning, communicating to various audiences. Major aspects of Implementation are described: quality management, managing academics and risk, transnational and trans-sectorial working (between academia and industry), novel methodologies and finally the career implications for PhD students involved. These are honest and pragmatic reflections on the way to best practice
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