Segue: Overviewing Evolution Patterns of Egocentric Networks by Interactive Construction of Spatial Layouts

Getting the overall picture of how a large number of ego-networks evolve is a common yet challenging task. Existing techniques often require analysts to inspect the evolution patterns of ego-networks one after another. In this study, we explore an approach that allows analysts to interactively create spatial layouts in which each dot is a dynamic ego-network. These spatial layouts provide overviews of the evolution patterns of ego-networks, thereby revealing different global patterns such as trends, clusters and outliers in evolution patterns. To let analysts interactively construct interpretable spatial layouts, we propose a data transformation pipeline, with which analysts can adjust the spatial layouts and convert dynamic egonetworks into event sequences to aid interpretations of the spatial positions. Based on this transformation pipeline, we developed Segue, a visual analysis system that supports thorough exploration of the evolution patterns of ego-networks. Through two usage scenarios, we demonstrate how analysts can gain insights into the overall evolution patterns of a large collection of ego-networks by interactively creating different spatial layouts.Comment: Published at IEEE Conference on Visual Analytics Science and Technology (IEEE VAST 2018

A Massive Protostar Embedded in the Scuba Core JCMT 18354-0649S

We report the discovery of an extremely red object embedded in the massive SCUBA core JCMT 18354-0649S. This object is not associated with any known radio or far-IR source, though it appears in Spitzer IRAC data obtained as part of the GLIMPSE survey. At shorter wavelengths, this embedded source exhibits an extreme color, K – L' = 6.7. At an assumed distance of 5.7 kpc, this source has a near-IR luminosity of ~1000 L_☉. Its spectral energy distribution (SED) rises sharply from 2.1 μm to 8 μm, similar to that of a Class 0 young stellar object. Theoretical modeling of the SED indicates that the central star has a mass of 6-12 M_☉, with an optical extinction of more than 30. As both inflow and outflow motions are present in JCMT 18354-0649S, we suggest that this deeply embedded source is (1) a massive protostar in the early stages of accretion, and (2) the driving source of a massive molecular outflow evident in HCN J = 3-2 profiles observed toward this region

Deletion of internal twenty-one amino acid residues of Escherichia coli prolipoprotein does not affect the formation of the murein-bound lipoprotein

AbstractMutation pgsA affecting the phosphatidylglycerol phosphate synthesis is lethal for all but certain E. coli strains such as strains deleted for the lpp gene or strains containing unmodifiable prolipoprotein like lppD14. Strain SD312 pgsA3 is tolerant to pgsA mutation, which suggests the lpp alleles in strain SD312 pgsA3 and its parental strain SD12 may be defective. DNA sequence analysis of the lpp genes in Escherichia coli strains SD12 and SD312 pgsA using asymmetric polymerase chain reaction showed that the lpp alleles in these two strains contained a 63 base pair deletion corresponding to the 37th to 57th codons of the wild-type lpp gene. [3H]Palmitate labeling of strains SD12 and SDS312 showed that the mutant lipoprotein in SD12 strain was modified with lipid, while the prolipoprotein in SD312 was not modified. The shortened mature lipoprotein in SD12 and the lipid-modified prolipoprotein in globomycin-treated SD12 were found to be covalently attached to the peptidoglycan, while the unmodified prolipoprotein in SD312 did not form significant amounts of murein-bound lipoprotein