Trapping effects on inflation

We develop a Lagrangian approach based on the influence functional method so as to derive self-consistently the Langevin equation for the inflaton field in the presence of trapping points along the inflaton trajectory. The Langevin equation exhibits the backreaction and the fluctuation-dissipation relation of the trapping. The fluctuation is induced by a multiplicative colored noise that can be identified as the the particle number density fluctuations and the dissipation is a new effect that may play a role in the trapping with a strong coupling. In the weak coupling regime, we calculate the power spectrum of the noise-driven inflaton fluctuations for a single trapping point and studied its variation with the trapping location. We also consider a case with closely spaced trapping points and find that the resulting power spectrum is blue.Comment: 13 pages, 2 figure

Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T

AbstractWe present the results of a study of human prostate specimens evaluated by high resolution magic angle spinning 1H nuclear magnetic resonance (NMR) spectroscopy at 400 MHz (9.4 T) and by quantitative histopathology. We demonstrate that NMR and pathology data can be obtained from the same intact specimens, and report for the first time a linear correlation between the NMR measured concentration of spermine, a proposed endogenous inhibitor to prostate cancer growth, and the volume percentage of normal prostatic epithelial cells as quantified by histopathology. Our results show that NMR may serve as a critical tool for the investigation of the inhibitory mechanism of spermine in human subjects

Signs of outflow feedback from a nearby young stellar object on the protostellar envelope around HL Tau

HL Tau is a Class I-II protostar embedded in an infalling and rotating envelope and possibly associated with a planet forming disk, and it is co-located in a 0.1 pc molecular cloud with two nearby young stellar objects. Our ALMA observations revealed two arc-like structures on a 1000 au scale connected to the disk, and their kinematics could not be explained with any conventional model of infalling and rotational motions. In this work, we investigate the nature of these arc-like structures connected to the HL Tau disk. We conducted new observations in the 13CO and C18O (3-2; 2-1) lines with JCMT and IRAM 30m, and obtained the ACA data with the 7-m array. With the single-dish, ACA, and ALMA data, we analyzed the gas motions on both 0.1 pc and 1000 au scales in the HL Tau region. We constructed new kinematical models of an infalling and rotating envelope with the consideration of relative motion between HL Tau and the envelope. By including the relative motion between HL Tau and its protostellar envelope, our kinematical model can explain the observed velocity features in the arc-like structures. The morphologies of the arc-like structures can also be explained with an asymmetric initial density distribution in our model envelope. In addition, our single-dish results support that HL Tau is located at the edge of a large-scale (0.1 pc) expanding shell driven by the wind or outflow from XZ Tau, as suggested in the literature. The estimated expanding velocity of the shell is comparable to the relative velocity between HL Tau and its envelope in our kinematical model. These results hints that the large-scale expanding motion likely impacts the protostellar envelope around HL Tau and affects its gas kinematics. We found that the mass infalling rate from the envelope onto the HL Tau disk can be decreased by a factor of two due to this impact by the large-scale expanding shell.Comment: Accepted by A&

Spontaneous Dissecting Aneurysm of the Renal Artery: A Case Report

Primary dissecting aneurysms of the renal artery are exceedingly rare. The triad of flank pain, hematuria, and hypertension of acute onset in the absence of urinary obstruction should suggest this rare condition. We report a case of spontaneous dissecting aneurysm of the renal artery treated using conservative medical treatment. The diagnosis, therapeutic management, and outcome are discussed

Phylo-mLogo: an interactive and hierarchical multiple-logo visualization tool for alignment of many sequences

BACKGROUND: When aligning several hundreds or thousands of sequences, such as epidemic virus sequences or homologous/orthologous sequences of some big gene families, to reconstruct the epidemiological history or their phylogenies, how to analyze and visualize the alignment results of many sequences has become a new challenge for computational biologists. Although there are several tools available for visualization of very long sequence alignments, few of them are applicable to the alignments of many sequences. RESULTS: A multiple-logo alignment visualization tool, called Phylo-mLogo, is presented in this paper. Phylo-mLogo calculates the variabilities and homogeneities of alignment sequences by base frequencies or entropies. Different from the traditional representations of sequence logos, Phylo-mLogo not only displays the global logo patterns of the whole alignment of multiple sequences, but also demonstrates their local homologous logos for each clade hierarchically. In addition, Phylo-mLogo also allows the user to focus only on the analysis of some important, structurally or functionally constrained sites in the alignment selected by the user or by built-in automatic calculation. CONCLUSION: With Phylo-mLogo, the user can symbolically and hierarchically visualize hundreds of aligned sequences simultaneously and easily check the changes of their amino acid sites when analyzing many homologous/orthologous or influenza virus sequences. More information of Phylo-mLogo can be found at URL

Effect on Spasticity After Performance of Dynamic-Repeated-Passive Ankle Joint Motion Exercise in Chronic Stroke Patients

Spasticity associated with abnormal muscle tone is a common motor disorder following stroke, and the spastic ankle may affect ambulatory function. The purpose of this study was to investigate the short-term effect of dynamic-repeated-passive ankle movements with weight loading on ambulatory function and spastic hypertonia of chronic stroke patients. In this study, 12 chronic stroke patients with ankle spasticity and inefficient ambulatory ability were enrolled. Stretching of the plantar-flexors of the ankle in the standing position for 15 minutes was performed passively by a constant-speed and electrically powered device. The following evaluations were done before and immediately after the dynamic-repeated-passive ankle movements. Spastic hypertonia was assessed by the Modified Ashworth Scale (MAS; range, 0–4), Achilles tendon reflexes test (DTR; range, 0–4), and ankle clonus (range, 0–5). Improvement in ambulatory ability was determined by the timed up-and-go test (TUG), the 10-minute walking test, and cadence (steps/minute). In addition, subjective experience of the influence of ankle spasticity on ambulation was scored by visual analog scale (VAS). Subjective satisfaction with the therapeutic effect of spasticity reduction was evaluated by a five-point questionnaire (1 = very poor, 2 = poor, 3 = acceptable, 4 = good, 5 = very good). By comparison of the results before and after intervention, these 12 chronic stroke patients presented significant reduction in MAS and VAS for ankle spasticity, the time for TUG and 10-minute walking speed (p < 0.01). The cadence also increased significantly (p < 0.05). In addition, subjective satisfaction with the short-term therapeutic effect was mainly good (ranging from acceptable to very good). In conclusion, 15 minutes of dynamic-repeated-passive ankle joint motion exercise with weight loading in the standing position by this simple constant-speed machine is effective in reducing ankle spasticity and improving ambulatory ability