1,955 research outputs found
Omalizumab, an Anti-IgE mAb, Receives Approval for the Treatment of Chronic Idiopathic/Spontaneous Urticaria
Omalizumab, an anti-IgE mAb, has recently been approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of chronic idiopathic urticaria. Saini et al. (2014) (this issue) report on ASTERIA I, a 40-week randomized, double-blinded, placebo-controlled phase III trial evaluating omalizumab for the treatment of this disease
Cryptanalysis of an MPEG-Video Encryption Scheme Based on Secret Huffman Tables
This paper studies the security of a recently-proposed MPEG-video encryption
scheme based on secret Huffman tables. Our cryptanalysis shows that: 1) the key
space of the encryption scheme is not sufficiently large against
divide-and-conquer (DAC) attack and known-plaintext attack; 2) it is possible
to decrypt a cipher-video with a partially-known key, thus dramatically
reducing the complexity of the DAC brute-force attack in some cases; 3) its
security against the chosen-plaintext attack is very weak. Some experimental
results are included to support the cryptanalytic results with a brief discuss
on how to improve this MPEG-video encryption scheme.Comment: 8 pages, 4 figure
BES3 time of flight monitoring system
A Time of Flight monitoring system has been developed for BES3.
The light source is a 442-443 nm laser diode, which is stable and provides a
pulse width as narrow as 50 ps and a peak power as large as 2.6 W. Two
optical-fiber bundles with a total of 512 optical fibers, including spares, are
used to distribute the light pulses to the Time of Flight counters. The design,
operation, and performance of the system are described.Comment: 8 pages 16 figures, submitted to NI
A Non-coding RNA of Insect HzNV-1 Virus Establishes Latent Viral Infection through MicroRNA
Heliothis zea nudivirus-1 (HzNV-1) is an insect virus previously known as Hz-1 baculovirus. One of its major early genes, hhi1, is responsible for the establishment of productive viral infection; another gene, pag1, which expresses a non-coding RNA, is the only viral transcript detectable during viral latency. Here we showed that this non-coding RNA was further processed into at least two distinct miRNAs, which targeted and degraded hhi1 transcript. This is a result strikingly similar to a recent report that herpes simplex virus produces tightly-regulated latent specific miRNAs to silence its own key early transcripts. Nevertheless, proof for the establishment of viral latency by miRNA is still lacking. We further showed that HzNV-1 latency could be directly induced by pag1-derived miRNAs in cells infected with a pag1-deleted, latency-deficient virus. This result suggests the existence of a novel mechanism, where miRNAs can be functional for the establishment of viral latency
Gravity on codimension 2 brane worlds
We compute the matching conditions for a general thick codimension 2 brane, a
necessary previous step towards the investigation of gravitational phenomena in
codimension 2 braneworlds. We show that, provided the brane is weakly curved,
they are specified by the integral in the extra dimensions of the brane
energy-momentum, independently of its detailed internal structure. These
general matching conditions can then be used as boundary conditions for the
bulk solution. By evaluating Einstein equations at the brane boundary we are
able to write an evolution equation for the induced metric on the brane
depending only on physical brane parameters and the bulk energy-momentum
tensor. We particularise to a cosmological metric and show that a realistic
cosmology can be obtained in the simplest case of having just a non-zero
cosmological constant in the bulk. We point out several parallelisms between
this case and the codimension 1 brane worlds in an AdS space.Comment: 24 page
Superconducting properties of RuSr2GdCu2O8 studied by SQUID magnetometry
For polycrystalline RuSr2GdCu2O8 (Ru-1212), distinct peaks have been reported
in d.c. magnetization in the superconducting state of the sample. Sr2GdRuO6
(Sr-2116), the precursor for the preparation of Ru-1212, shows similar peaks in
the same temperature regime. Based on measurements performed on both bulk and
powdered samples of Ru-1212 and Sr-2116, we exclude the possibility, that the
observed behavior of the magnetization of Ru-1212 is due to Sr-2116 impurities.
The effect is related to the superconductivity of Ru-1212, but it is not an
intrinsic property of this compound. We provide evidence that the observation
of magnetization peaks in the superconducting state of Ru-1212 is due to flux
motion generated by the movement of the sample in an inhomogeneous field,
during the measurement in the SQUID magnetometer. We propose several tests,
that help to decide, whether the features observed in a SQUID magnetization
measurement of Ru-1212 represent a property of the compound or not.Comment: 22 pages, 9 figure
The association between distal findings and proximal colorectal neoplasia: a systematic review and meta-analysis
Objectives:
Whether screening participants with distal hyperplastic polyps (HPs) detected by flexible sigmoidoscopy (FS) should be followed by subsequent colonoscopy is controversial. We evaluated the association between distal HPs and proximal neoplasia (PN)/advanced proximal neoplasia (APN) in asymptomatic, average-risk patients.
Methods:
We searched Ovid Medline, EMBASE, and the Cochrane Library from inception to 30 June 2016 and included all screening studies that examined the relationship between different distal findings and PN/APN. Data were independently extracted by two reviewers with disagreements resolved by a third reviewer. We pooled absolute risks and odds ratios (ORs) with a random effects meta-analysis. Seven subgroup analyses were performed according to study characteristics. Heterogeneity was characterized with theI2 statistics.
Results:
We analyzed 28 studies (104,961 subjects). When compared with normal distal findings, distal HP was not associated with PN (OR=1.16, 95% confidence interval (CI)=0.89–1.51,P=0.14,I2=40%) or APN (OR=1.09, 95% CI=0.87–1.36,P=0.39,I2=5%), while subjects with distal non-advanced or advanced adenoma had higher odds of PN/APN. Higher odds of PN/APN were observed for more severe distal lesions. Weaker association between distal and proximal findings was noticed in studies with higher quality, larger sample size, population-based design, and more stringent endoscopy quality-control measures. The Egger’s regression tests showed allP>0.05.
Conclusions:
Distal HP is not associated with PN/APN in asymptomatic screening population when compared with normal distal findings. Hence, the presence of distal HP alone detected by FS does not automatically indicate colonoscopy referral for all screening participants, as other risk factors of PN/APN should be considered
Nonexotic Neutral Gauge Bosons
We study theoretical and experimental constraints on electroweak theories
including a new color-singlet and electrically-neutral gauge boson. We first
note that the electric charges of the observed fermions imply that any such Z'
boson may be described by a gauge theory in which the Abelian gauge groups are
the usual hypercharge along with another U(1) component in a kinetic-diagonal
basis. Assuming that the observed quarks and leptons have
generation-independent U(1) charges, and that no new fermions couple to the
standard model gauge bosons, we find that their U(1) charges form a
two-parameter family consistent with anomaly cancellation and viable fermion
masses, provided there are at least three right-handed neutrinos. We then
derive bounds on the Z' mass and couplings imposed by direct production and
Z-pole measurements. For generic charge assignments and a gauge coupling of
electromagnetic strength, the strongest lower bound on the Z' mass comes from
Z-pole measurements, and is of order 1 TeV. If the new U(1) charges are
proportional to B-L, however, there is no tree-level mixing between the Z and
Z', and the best bounds come from the absence of direct production at LEPII and
the Tevatron. If the U(1) gauge coupling is one or two orders of magnitude
below the electromagnetic one, these bounds are satisfied for most values of
the Z' mass.Comment: 26 pages, 2 figures. A comparison with the LEP bounds on sneutrino
resonances is include
Characterization of 13 multi-drug resistant Salmonella serovars from different broiler chickens associated with those of human isolates
<p>Abstract</p> <p>Background</p> <p><it>Salmonella </it>are frequently isolated from chickens and their products. Prevalent serogroups and serovars of <it>Salmonella </it>as well as their genotypes and antibiograms were determined for cloacal samples from 1595 chickens. To understand the possible serovar and H antigens for transmission between chicken and human, serovars and their H antigens of 164 chicken and 5314 human isolates were compared.</p> <p>Results</p> <p>Prevalence of <it>Salmonella </it>differed among chicken lines and ages. Chicken and human isolates belonged mainly to serogroup B, C1, C2-C3, D, and E. 13 serovars and 66 serovars were identified for chicken and human isolates respectively. The common serovars for chicken and human isolates were <it>S</it>. Typhimurium, <it>S</it>. Enteritidis, <it>S</it>. Albany, <it>S</it>. Derby, and <it>S</it>. Anatum and shared common H1 antigens "g complex; i; e,h; and z4,z24" and H2 antigens "1 complex and -". In human isolates, H1 antigen "i" and H2 antigen "-" were common in all serogroups. In chicken, antimicrobial susceptibility differed among serogroups, serovars and three counties. All isolates were susceptible to cefazolin and ceftriaxone, but highly resistant to ampicillin, chloramphenicol, flumequine, streptomycin, sulfamethoxazole-trimethoprim, and tetracycline. Except those isolates of serogroup C1 of Chick group and serogroup G, all isolates were multi-drug resistance. Only <it>S</it>. Kubacha, <it>S</it>. Typhimurium, <it>S</it>. Grampian, and <it>S</it>. Mons were resistant to ciprofloxacin and/or enrofloxacin.</p> <p>Conclusion</p> <p>In chicken, prevalent serogroups and serovars were associated with chicken ages, lines and regions; and flouroquinolone-resistant and MDR isolates emerged. H1 antigens "g complex and i" and H2 antigens "1 complex and -" might be important for transmission of <it>Salmonella </it>between chicken and human.</p
A new constitutive model for prediction of impact rates response of polypropylene
This paper proposes a new constitutive model for predicting the impact rates response of polypropylene. Impact rates, as used here, refer to strain rates greater than 1000 1/s. The model is a physically based, three-dimensional constitutive model which incorporates the contributions of the amorphous, crystalline, pseudo-amorphous and entanglement networks to the constitutive response of polypropylene. The model mathematics is based on the well-known Glass-Rubber model originally developed for glassy polymers but the arguments have herein been extended to semi-crystalline polymers. In order to predict the impact rates behaviour of polypropylene, the model exploits the well-known framework of multiple processes yielding of polymers. This work argues that two dominant viscoelastic relaxation processes – the alpha- and beta-processes – can be associated with the yield responses of polypropylene observed at low-rate-dominant and impact-rates dominant loading regimes. Compression test data on polypropylene have been used to validate the model. The study has found that the model predicts quite well the experimentally observed nonlinear rate-dependent impact response of polypropylene
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