Práticas e manejo de sistemas de integração lavoura-pecuária-floresta com componente florestal para as regiões Centro-Oeste e Sudeste.

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Heart failure risk across the spectrum of ankle-brachial index: The ARIC study (Atherosclerosis RiskIn Communities)

The aim of this study was to describe the relationship between ankle brachial index (ABI) and the risk for heart failure (HF). Background: The ABI is a simple, noninvasive measure associated with atherosclerotic cardiovascular disease and death; however, the relationship between ABI and risk for HF is less well characterized. Methods: Between 1987 and 1989 in the ARIC (Atherosclerosis Risk In Communities) study, an oscillometric device was used to measure blood pressure in a single upper and randomly chosen lower extremity to determine the ABI. Incident HF events were defined by the first hospitalization with an International Classification of Diseases, Ninth Revision, code of 428.x through 2008. The risk for HF was assessed across the ABI range using restricted cubic splines and Cox proportional hazards models. Results: ABI was available in 13,150 participants free from prevalent HF. Over a mean 17.7 years of follow-up, 1,809 incident HF events occurred. After adjustment for traditional HF risk factors, prevalent coronary heart disease, subclinical carotid atherosclerosis, and interim myocardial infarction, compared with an ABI of 1.01 to 1.40, participants with ABIs≤0.90 were at increased risk for HF (hazard ratio: 1.40; 95% confidence interval: 1.12 to 1.74), as were participants with ABIs of 0.91 to 1.00 (hazard ratio: 1.36; 95% confidence interval: 1.17 to 1.59). Conclusions: In a middle-age community cohort, an ABI≤1.00 was significantly associated with an increased risk for HF, independent of traditional HF risk factors, prevalent coronary heart disease, carotid atherosclerosis, and interim myocardial infarction. Low ABI may reflect not only overt atherosclerosis but also pathologic processes in the development of HF beyond epicardial atherosclerotic disease and myocardial infarction alone. A low ABI, as a simple, noninvasive measure, may be a risk marker for HF

8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis

BACKGROUND: Breast cancer is a heterogeneous disease that is not totally eradicated by current therapies. The classification of breast tumors into distinct molecular subtypes by gene profiling and immunodetection of surrogate markers has proven useful for tumor prognosis and prediction of effective targeted treatments. The challenge now is to identify molecular biomarkers that may be of functional relevance for personalized therapy of breast tumors with poor outcome that do not respond to available treatments. The Mitochondrial Tumor Suppressor (MTUS1) gene is an interesting candidate whose expression is reduced in colon, pancreas, ovary and oral cancers. The present study investigates the expression and functional effects of MTUS1 gene products in breast cancer. METHODS AND FINDINGS: By means of gene array analysis, real-time RT-PCR and immunohistochemistry, we show here that MTUS1/ATIP3 is significantly down-regulated in a series of 151 infiltrating breast cancer carcinomas as compared to normal breast tissue. Low levels of ATIP3 correlate with high grade of the tumor and the occurrence of distant metastasis. ATIP3 levels are also significantly reduced in triple negative (ER- PR- HER2-) breast carcinomas, a subgroup of highly proliferative tumors with poor outcome and no available targeted therapy. Functional studies indicate that silencing ATIP3 expression by siRNA increases breast cancer cell proliferation. Conversely, restoring endogenous levels of ATIP3 expression leads to reduced cancer cell proliferation, clonogenicity, anchorage-independent growth, and reduces the incidence and size of xenografts grown in vivo. We provide evidence that ATIP3 associates with the microtubule cytoskeleton and localizes at the centrosomes, mitotic spindle and intercellular bridge during cell division. Accordingly, live cell imaging indicates that ATIP3 expression alters the progression of cell division by promoting prolonged metaphase, thereby leading to a reduced number of cells ungergoing active mitosis. CONCLUSIONS: Our results identify for the first time ATIP3 as a novel microtubule-associated protein whose expression is significantly reduced in highly proliferative breast carcinomas of poor clinical outcome. ATIP3 re-expression limits tumor cell proliferation in vitro and in vivo, suggesting that this protein may represent a novel useful biomarker and an interesting candidate for future targeted therapies of aggressive breast cancer

Eficiência de fungicidas para o controle da podridão de grãos da soja, na safra 2022/2023: resultados sumarizados dos ensaios cooperativos.

Desde o aparecimento do problema nas regiões tem sido observada diferença de reação entre as cultivares e redução dos sintomas com a aplicação de fungicidas. Uma rede de ensaios foi formada para avaliar a sensibilidade das cultivares e a eficiência de fungicidas na podridão de grãos. A podridão de grãos é observada a partir do início de enchimento de grãos, estádio R5. Externamente, as vagens podem apresentar sintomas de encharcamento e/ou escurecimento, sem abertura visível. Quando abertas, apresentam apodrecimento dos grãos. A presença de vagens com sintomas e os grãos apodrecidos ocorrem de forma aleatória na planta e na vagem, respectivamente, não necessariamente acometendo todos os grãos. Os fungos que predominam nos isolamentos a partir dos grãos e vagens (com e sem sintomas) são diferentes espécies de Diaporthe, Fusarium, Colletotrichum e, em algumas safras, também foi observada alta incidência de mancha-púrpura nos grãos, causada por Cercospora spp. Todos esses fungos e outros podem ser encontrados de forma latente na planta e nos grãos, como endofíticos, sem causar sintomas aparentes (Sinclair, 1991), cada um associado a uma doença quando ocorrem os sintomas. Sintomas de podridão de grãos da soja têm sido relatados com maior frequência na região do médio-norte do estado de Mato Grosso e em Rondônia, a partir da safra 2018/2019, com severidades variadas entre as safras e cultivares. Esses patógenos são comuns nas diferentes regiões sojícolas do País. A maior incidência de problemas na região médio-norte do Mato Grosso e em Rondônia pode estar associada a condições climáticas favoráveis, como estresses climáticos que fazem com que os fungos latentes se tornem patógenos, e sensibilidade das cultivares. Os fatores que desencadeiam a maior frequência de apodrecimento de grãos por esses patógenos nessas regiões ainda estão em estudo. O objetivo desta publicação é apresentar os resultados sumarizados dos experimentos cooperativos, realizados na safra 2022/2023, no médio-norte do Mato Grosso e em Rondônia, no controle da podridão de grãos na cultura da soja