9 research outputs found

    AGREEMENT No K944

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    Agreement to invite Project Associate

    Adult stem cell activity in naked mole rats for long-term tissue maintenance

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    The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU labelling and a quantitative imaging approach to track intestinal ASCs (Lgr5+) in their native in vivo state, we find an expanded pool of Lgr5+ cells in NMRs, and these cells specifically at the crypt base (Lgr5+CBC) exhibit slower division rates compared to those in short-lived mice but have a similar turnover as human LGR5+CBC cells. Instead of entering quiescence (G0), NMR Lgr5+CBC cells reduce their division rates by prolonging arrest in the G1 and/or G2 phases of the cell cycle. Moreover, we also observe a higher proportion of differentiated cells in NMRs that confer enhanced protection and function to the intestinal mucosa which is able to detect any chemical imbalance in the luminal environment efficiently, triggering a robust pro-apoptotic, anti-proliferative response within the stem/progenitor cell zone

    European Reference Genome Atlas Community - Phase 1 Members - 2020-2023

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    This dataset presents a comprehensive list of members registered as part of the European Reference Genome Atlas (ERGA, erga-biodiversity.eu) Community during ERGA Phase 1, which spanned from 2020 to 2023. The dataset includes information on the various roles undertaken by these members, particularly those who played a key role in establishing ERGA. Founding members are individuals who joined ERGA prior to the first leadership elections in February 2021, and they were instrumental in building the initial structure of ERGA. Some of these founding members were also involved in the establishment of different ERGA Committees. The dataset further includes details about the current and former core members and chairs of the ERGA committees. Additionally, it provides a list of the current (2023) and former Council members, along with the countries they represent. The dataset is organised in alphabetical order for ease of reference. The co-authors of this dataset encompass both current and former ERGA Council members, listed in alphabetical order, and the current ERGA chair, as the last author

    Metadata record for: COVIDiSTRESS Global Survey dataset on psychological and behavioural consequences of the COVID-19 outbreak

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    This dataset contains key characteristics about the data described in the Data Descriptor COVIDiSTRESS Global Survey dataset on psychological and behavioural consequences of the COVID-19 outbreak. Contents: 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON forma
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