58 research outputs found
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Afterlives of BBC Radio features
BBC Radio feature programmes written by established literary figures in the mid-twentieth century enjoyed richly creative afterlives across many decades and in a variety of media—for example, in print, as commercial recordings, in theatre performance and on television—as well as in a succession of new productions on radio. This activity kept works alive in the public imagination beyond the ephemeral moment of first broadcast and, it is argued, contributed to the sense (for audiences past and scholars present) of an informal canon of literary radio features. This essay explores the intermedial afterlives of three such literary features—Sackville-West’s The Rescue (1943), MacNeice’s The Dark Tower (1946) and Thomas’ Under Milk Wood (1954)—in order to demonstrate the significance of the form as a site for exploration of social issues, politics and cultural life. The essay concludes with a call for more wide-ranging attention to the protean feature form, including work that may not have persisted in the schedules, or had rich, intermedial afterlives, but that may still offer significant insights into the history of social, political and cultural life in mid-twentieth-century Britain
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Robert Bridges' Masque <i>Demeter</i> and Oxford's Persephones
This essay takes as its focus Robert Bridges’ masque Demeter and its first performance in 1904 by the women students of Somerville, Oxford as part of the official opening ceremony for their new Library. It considers how Bridges’ elegant retelling of the myth of Persephone— which draws on the Homeric Hymn to Demeter—provides an appropriate allegory of wisdom and maturation and a suggestive commentary on how the higher education of women at this time was understood to prepare them for their future roles in society. The paper also shows how the occasion as a whole raised the profile of this all-female hall amongst the overwhelmingly male colleges and University of Oxford. Women students were very far from being on an equal footing with their male coevals at this time, not only in terms of educational status but also in terms of recreational opportunities. The performance of Demeter, however, set a firm precedent for dramatic performance within women’s halls. The paper describes how, soon after the performance, women scholars of Somerville contributed to the more decorative aspects of the Oxford University Dramatic Society’s Greek play productions from 1905; and how the classicist Gilbert Murray—who was actively involved in the education of women at Oxford, enjoying a long and special relationship with Somerville in particular—vigorously and practically encouraged the performance of Greek plays in translation and adaptation in the women’s halls
'Countries in the Air': Travel and Geomodernism in Louis MacNeice's BBC Features
In the middle stretch of his twenty-two-year BBC career, the poet and producer Louis MacNeice earned a reputation as one of the ‘undisputed masters of creative sound broadcasting’, a reputation derived, in part, from a huge range of radio features that were founded upon his journeys abroad. Through close examination of some of his most significant overseas soundscapes – including Portrait of Rome (1947) and Portrait of Delhi (1948) – this article will consider the role and function of travel in shaping MacNeice’s engagement with the radio feature as a modernist form at a particular transcultural moment when Britain moved through the end of the Second World War and the eventual disintegration of its empire
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
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Performing Greek drama in Oxford and on tour with the Balliol Players
Performing Greek Drama in Oxford traces enduring connections between antiquity and dramatic performance in modern Oxford, discussing landmark events from the 16th century to the 1970s. This performance history of classical texts, especially those by the Greek dramatists, illuminates contemporary responses to debates on such matters as the position of women students, the dangers perceived to be associated with undergraduate acting and the position of classics within the curriculum at the University of Oxford. The book consistently engages with the history of theatrical performance of ancient plays beyond Oxford, for example, John Masefield’s Boars Hill Players, Penelope Wheeler’s Greek plays at the Front, and the link with the London stage through companies touring to Oxford, such as that led by Sybil Thorndike. Many of these engagements with Greek drama were facilitated by the connection with the classical scholar Gilbert Murray, who plays a central part in the history. The final chapters tell the story of the Balliol Players, a group of students who, fired by the post-war missionary enthusiasm of the early 1920s and supported by the elderly Thomas Hardy, determined to take Greek plays in translation to school and public audiences in the south and west of England in their summer vacations. Born from a socially idealistic impulse, the tradition lasted for over five decades, during which time these summer tours evolved from earnest productions of tragedy to satirical and irreverent re-writings of Aristophanes, typical of the spirit of the 1960s
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Practising classical reception studies 'in the round': mass media engagements with antiquity and the 'democratic turn' towards the audience
This chapter argues for a refinement of current methodological practice within classical reception studies founded on the existence in the archives of a substantial amount of evidence for historical audience opinions on BBC Radio and BBC Television engagements with ancient Greek and Roman culture. Specifically, the simplistic Jaussian equation of ‘production’ and ‘reception’ must be re-thought; an alternative model founded on the idea of ‘engagement’ is promoted. The existence of a rich mine of evidence for audience engagement for mass media opens up new possibilities for classical reception studies practice even in those few areas where genuinely no similar evidence exists. Furthermore, an ‘in the round’ study of engagements with antiquity is advocated—that is, from as many different perspectives and in as many contexts as the available evidence allows, rather than along the customary one- or two-track approach along well-trodden literary, aesthetic or political paths
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