837 research outputs found
Guidelines (1988) for training in clinical laboratory management
Trainees in laboratory medicine must develop skills in laboratory
management. Guidelines are detailed for laboratory staff in
training, directors responsible for staff development and professional
bodies wishing to generate material appropriate to their
needs. The syllabus delineates the knowledge base required and
includes laboratory planning and organization, control of operations,
methodology and instrumentation, data management and
statistics, financial management, clinical use of tests, communication,
personnel management and training and research and
development. Methods for achievement of the skills required are
suggested. A bibliography of IFCC publications and other
material is provided to assist in training in laboratory management
Anomalous molecular dynamics in the vicinity of conical intersections
Conical intersections between molecular electronic potential surfaces greatly
affect various properties of the molecule. Molecular gauge theory is capable of
explaining many of these often unexpected phenomena deriving from the physics
of the conical intersection. Here we give an example of anomalous dynamics in
the paradigm of the Exe Jahn-Teller model, which does not allow a simple
explenation in terms of standard molecular gauge theory. By introducing a dual
gauge theory, we unwind this surprising behavior by identifying it with an
intrinsic spin Hall effect. Thus, this work link knowledge of condensed matter
theories with molecular vibrations. Furthermore, via ab initio calculations the
findings are as well demonstrated to appear in realistic systems such as the
Li3 molecule.Comment: 5 pages, 2 figure
Interpolated wave functions for nonadiabatic simulations with the fixed-node quantum Monte Carlo method
Simulating nonadiabatic effects with many-body wave function approaches is an
open field with many challenges. Recent interest has been driven by new
algorithmic developments and improved theoretical understanding of properties
unique to electron-ion wave functions. Fixed-node diffusion Monte Caro is one
technique that has shown promising results for simulating electron-ion systems.
In particular, we focus on the CH molecule for which previous results suggested
a relatively significant contribution to the energy from nonadiabatic effects.
We propose a new wave function ansatz for diatomic systems which involves
interpolating the determinant coefficients calculated from configuration
interaction methods. We find this to be an improvement beyond previous wave
function forms that have been considered. The calculated nonadiabatic
contribution to the energy in the CH molecule is reduced compared to our
previous results, but still remains the largest among the molecules under
consideration.Comment: 7 pages, 3 figure
New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT
This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent 474 HSCTs at 2 supraregional United Kingdom centers. At a median of 153 days post-HSCT, TA-TMA occurred among 25 of 441 evaluable cases (5.6%) with no evidence of center variation. Sex, underlying disease, intensity of the conditioning, total body irradiation–based conditioning, the use of calcineurin inhibitors, venoocclusive disease, and viral reactivation did not influence the development of TA-TMA. Donor type: matched sibling donor/matched family donor vs matched unrelated donor vs mismatched unrelated donor/haplo-HSCT, showed a trend toward the development of TA-TMA in 1.8% vs 6.1% vs 8.3%, respectively. Presence of active comorbidity was associated with an increased risk for TA-TMA; 13% vs 3.7% in the absence of comorbidity. The risk of TA-TMA was threefold higher among patients who received >1 transplant. TA-TMA rates were significantly higher among patients with acute graft-versus-host disease (aGVHD) grades III to IV vs aGVHD grade 0 to II. On multivariate analysis, the presence of active comorbidity, >1 transplant, aGVHD grade III to IV were risk factors for TA-TMA (odds ratio [OR]: 5.1, 5.2, and 26.9; respectively), whereas the use of cyclosporine A/tacrolimus-based GVHD prophylaxis was not a risk factor for TA-TMA (OR: 0.3). Active comorbidity, subsequent transplant, and aGVHD grades III to IV were significant risk factors for TA-TMA. TA-TMA might represent a form of a vascular GVHD, and therefore, continuing control of aGVHD is important to prevent worsening of TA-TMA associated with GVHD
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