121 research outputs found
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Low-Cost, High-Resolution and High-Sensitivity PET Detector Modules
PET detector modules using CsI(Na), wavelength-shifting fiber readout, and single-photon counting electronic
A Scintillating Fiber Hodoscope for a Bremstrahlung Luminosity Monitor at an ElectronPositron Collider
The performance of a scintillating fiber (2mm diameter) position sensitive
detector ( cm active area) for the single bremstrahlung
luminosity monitor at the VEPP-2M electron-positron collider in Novosibirsk,
Russia is described. Custom electronics is triggered by coincident hits in the
X and Y planes of 24 fibers each, and reduces 64 PMT signals to a 10 bit (X,Y)
address. Hits are accumulated (10 kHz) in memory and display (few Hz) the
VEPP-2M collision vertex. Fitting the strongly peaked distribution ( 3-4
mm at 1.6m from the collision vertex of VEPP-2M ) to the expected QED angular
distribution yields a background in agreement with an independent determination
of the VEPP-2M luminosity.Comment: LaTeX with REVTeX style and options: multicol,aps. 8 pages,
postscript figures separate from text. Accepted in Review of Scientific
Instruments (~ Aug 1996
The Lowest Order Hadronic Contribution to the Muon Value with Systematic Error Correlations
We have performed a new evaluation of the hadronic contribution to
of the muon with explicit correlations of systematic errors
among the experimental data on . Our result for
the lowest order hadronic vacuum polarization contribution is where the the first error is statistical and
the second is systematic. The total systematic error contributions from below
and above GeV are and respectively, and are hence dominated by the low energy region.
Therefore, new measurements on below 1.4 GeV can
significantly reduce the total error on . In particular, the
effect on the total errors of new hypothetical data with 3 \% statistical and
0.5 - 1.0 \% systematic errors is presented.Comment: LaTeX with REVTeX style and options: multicol,aps,psfig. 18 pages,
postscript figures included after text. Accepted in Phys. Rev. D (~ Sept
1996
SEARCH FOR SLOWLY MOVING MAGNETIC MONOPOLES WITH THE MACRO DETECTOR
A search for slowly moving magnetic monopoles in the cosmic radiation was conducted from October 1989 to November 1991 using the large liquid scintillator detector subsystem of the first supermodule of the MACRO detector at the Gran Sasso underground laboratory. The absence of candidates established an upper limit on the monopole flux of 5.6 x 10(-15) cm-2 sr-1 s-1 at 90% confidence level in the velocity range of 10(-4) less than or similar to beta < 4 x 10(-3). This result places a new constraint on the abundance of monopoles trapped in our solar system
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Preliminary results from the CMD-2 detector
A new general-purpose detector CMD-2 (calorimetric magnetic detector has started experiments at the upgraded e{sup {plus}}e{sup {minus}} collider VEPP-2M (collider for electron-positron beams) at Novosibirsk. During early runs an integrated luminosity of about 400 inverse nanobarns has been collected in the center of mass energy range 400{endash}1030 MeV
Machine learning based CRISPR gRNA design for therapeutic exon skipping
© 2021 Louie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Restoring gene function by the induced skipping of deleterious exons has been shown to be effective for treating genetic disorders. However, many of the clinically successful therapies for exon skipping are transient oligonucleotide-based treatments that require frequent dosing. CRISPR-Cas9 based genome editing that causes exon skipping is a promising therapeutic modality that may offer permanent alleviation of genetic disease. We show that machine learning can select Cas9 guide RNAs that disrupt splice acceptors and cause the skipping of targeted exons. We experimentally measured the exon skipping frequencies of a diverse genome-integrated library of 791 splice sequences targeted by 1,063 guide RNAs in mouse embryonic stem cells. We found that our method, SkipGuide, is able to identify effective guide RNAs with a precision of 0.68 (50% threshold predicted exon skipping frequency) and 0.93 (70% threshold predicted exon skipping frequency). We anticipate that SkipGuide will be useful for selecting guide RNA candidates for evaluation of CRISPR-Cas9-mediated exon skipping therapy
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