sj-docx-1-jet-10.1177_15266028241232915 – Supplemental material for Long-Term Outcomes of Endovascular Repair Within and Outside the Instructions for Use in Korean Patients With Abdominal Aortic Aneurysm

Supplemental material, sj-docx-1-jet-10.1177_15266028241232915 for Long-Term Outcomes of Endovascular Repair Within and Outside the Instructions for Use in Korean Patients With Abdominal Aortic Aneurysm by Joonpyo Lee, Pyung Chun Oh, Albert Youngwoo Jang, Chul-Min Ahn, Donghoon Choi, Young-Guk Ko and Woong Chol Kang in Journal of Endovascular Therapy</p

Predictive value of alkaline phosphatase (ALP) for major adverse cardiac and cerebrovascular event (MACCE).

<p>Predictive value of alkaline phosphatase (ALP) for major adverse cardiac and cerebrovascular event (MACCE).</p

Restricted cubic spline regression model of serum alkaline phosphatase (ALP) levels for a major adverse cardiac or cerebrovascular event (MACCE).

<p>Hazard ratios (HRs) were adjusted for the variables using in Model 2 on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0171914#pone.0171914.t004" target="_blank">Table 4</a>. Knots were placed at the 10^th, 50^th, and 90^th percentiles of the ALP distribution (at 52 IU/L, 73 IU/L, and 103 IU/L, respectively). The solid line presents HR and dotted line 95% confidence interval of HR.</p

Incidence of adverse clinical outcomes according to the tertiles of ALP levels.

<p>Incidence of adverse clinical outcomes according to the tertiles of ALP levels.</p

High sST2 and high NT-proBNP levels in combination had the highest adjusted hazard ratio.

<p>High sST2 and high NT-proBNP levels in combination had the highest adjusted hazard ratio.</p

Datasheet1_Long-term clinical outcomes for patients with uncrossable patent foramen ovale.docx

IntroductionPatent foramen ovale (PFO) closure is performed in selected patients with cryptogenic stroke to prevent recurrence. The prognosis of patients with uncrossable PFO after failed guidewire or catheter passage during the procedure remains unknown. We compared the long-term prognosis between uncrossable PFO and successful PFO closure in patients with high-grade PFO shunts.MethodsWe analyzed patients who underwent PFO closure for stroke or transient ischemic attack (TIA) prevention at Gachon University Gil Medical Center between April 2010 and March 2022. The primary outcome was a composite of recurrent stroke or TIA. Secondary outcomes included stroke, TIA, all-cause death, and a composite of stroke, TIA, and all-cause death.ResultsOf 286 patients, 245 were included in the analysis after excluding those with transseptal puncture technique usage or concurrent atrial septal defect. Among them, 82 had uncrossable PFO, and 163 underwent successful PFO closure. Large shunts were more prevalent in the PFO closure group compared to the uncrossable PFO group (62.0% vs. 34.1%, P ConclusionClinical outcomes for patients with uncrossable PFO seem similar to those with successful PFO closure.</p

Kaplan-Meier survival curves for MACCE during a year following primary PCI showed high sST2 level was associated with a poorer prognosis (A) and that high sST2 and high NT-proBNP levels in combination were associated with a worst prognosis than any other levels of combination (B).

<p>Kaplan-Meier survival curves for MACCE during a year following primary PCI showed high sST2 level was associated with a poorer prognosis (A) and that high sST2 and high NT-proBNP levels in combination were associated with a worst prognosis than any other levels of combination (B).</p

Image1_Long-term clinical outcomes for patients with uncrossable patent foramen ovale.tif

IntroductionPatent foramen ovale (PFO) closure is performed in selected patients with cryptogenic stroke to prevent recurrence. The prognosis of patients with uncrossable PFO after failed guidewire or catheter passage during the procedure remains unknown. We compared the long-term prognosis between uncrossable PFO and successful PFO closure in patients with high-grade PFO shunts.MethodsWe analyzed patients who underwent PFO closure for stroke or transient ischemic attack (TIA) prevention at Gachon University Gil Medical Center between April 2010 and March 2022. The primary outcome was a composite of recurrent stroke or TIA. Secondary outcomes included stroke, TIA, all-cause death, and a composite of stroke, TIA, and all-cause death.ResultsOf 286 patients, 245 were included in the analysis after excluding those with transseptal puncture technique usage or concurrent atrial septal defect. Among them, 82 had uncrossable PFO, and 163 underwent successful PFO closure. Large shunts were more prevalent in the PFO closure group compared to the uncrossable PFO group (62.0% vs. 34.1%, P ConclusionClinical outcomes for patients with uncrossable PFO seem similar to those with successful PFO closure.</p

Demographic characteristics at the time of presentation in the two groups.

<p>Demographic characteristics at the time of presentation in the two groups.</p

Major adverse cardiac or cerebrovascular event (MACCE)-free survival curve according to serum alkaline phosphatase level tertiles.

<p>Major adverse cardiac or cerebrovascular event (MACCE)-free survival curve according to serum alkaline phosphatase level tertiles.</p