14 research outputs found

    New insights into the genetic etiology of Alzheimer's disease and related dementias

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    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

    Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: What have we learnt?

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    10.1016/j.neubiorev.2011.09.001Neuroscience and Biobehavioral Reviews361556-571NBRE

    Liquid Crystalline Conjugated Polymers – Synthesis and Properties

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    White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies

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    10.1016/j.jad.2010.09.013Journal of Affective Disorders1321-226-36JADI

    Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: A decade of advance

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    10.1016/j.neubiorev.2010.01.002Neuroscience and Biobehavioral Reviews346958-97
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