Laparoscopic liver resection versus open liver resection for intrahepatic cholangiocarcinoma: 3-year outcomes of a cohort study with propensity score matching

Introduction: Laparoscopic liver resection(LLR) for intrahepatic cholangiocarcinoma is debatable due to technical challenges associated with major hepatectomy and lymph node dissection. This study aims to analyze the long-term outcomes with propensity score matching. Methods: Patients who underwent liver resection for intrahepatic cholangiocarcinoma from August 2004 to October 2015 were enrolled. Those who had combined hepatocellular-cholangiocarcinoma and palliative surgery were excluded. Medical records were reviewed for postoperative outcome, recurrence, and survival. The 3-year disease-free survival(DFS) and 3-year overall survival(OS) were set as the primary endpoint, and 3-year diseasespecific survival, 1-year OS, 1-year DFS, operative outcome, and postoperative complications were secondary endpoints. Results: A total of 91 patients were enrolled with 61 in the open group and 30 in the laparoscopic group. Propensity score matching included 24 patients in both groups. In total, the 3-year OS was 81.2% in the open group and 76.7% in the laparoscopic group(p = 0.621). For 3-year DFS, open was 42.5% and laparoscopic was 65.6% (p = 0.122). Mean operation time for the open group was 343.2 + 106.0 min and laparoscopic group was 375.2 + 204.0 min(p = 0.426). Hospital stay was significantly shorter in the laparoscopic group(9.8 + 5.1 days) than the open group(18.3 + 14.7, p=<0.001). There was no difference in complication rate and 30-day readmission rate. Tumor size, nodularity, and presence of perineural invasion showed an independent association with the 3-year DFS in multivariate analysis. Conclusion: Laparoscopic liver resection for intrahepatic cholangiocarcinoma is technically feasible and safe, providing short-term benefits without increasing complications or affecting long-term survival.N

Ruthenium(II) Quasi-Solid State Dye Sensitized Solar Cells with 8% Efficiency using Supramolecular Oligomer Based Electrolyte

We have achieved 8% efficiency for the ruthenium(ii) dye, SY-04, in quasi-solid state dye sensitized solar cells using a supramolecular oligomer-based electrolyte. The dyes in this study, SY-04 and SY-05, which were synthesized through highly efficient synthetic routes, showed better molar extinction coefficients compared to that of the Z907 dye. In the absorption spectra, SY-04 and SY-05 displayed better red shifted metal ligand charge transfer (MLCT) absorption bands at 533, 382 and 535, 373 nm, respectively, compared with 521, 371 nm of the Z907 dye. Also, SY-04 and SY-05 showed better molar extinction coefficients, 6691, 16 189 M-1 cm(-1) and 6694, 16 195 M-1 cm(-1) as compared with the Z907 dye, 4308, 4917 M-1 cm(-1). When excited into the charge-transfer absorption bands of SY-04 and SY-05 in ethanol at 77 K, broad emission bands for SY-04 and SY-05 with a maximum at 788 nm and 786 nm, respectively, were observed compared to the emission band of Z907 at 797 nm. The current-voltage characteristics of the SY-04 sensitizer gave the best performance data, J(SC) = 18.0 mA cm(-2), V-OC = 0.662 V, if = 0.663, and an eta of 8.0%. The increased V-OC value for SY-04 than Z907 is mainly attributed to high charge recombination resistance by effective dye coverage, which is confirmed by impedance spectroscopy.X1144sciescopu

Strongly coupled cyclometalated ruthenium triarylamine chromophores as sensitizers for DSSCs

A series of anchor-functionalized cyclometalated bis(tridentate) ruthenium(II) triarylamine hybrids [Ru(dbp-X)(tctpy)](2-) [2a](2-)-[2c](2-) (H(3)tctpy=2,2';6',2 ''-terpyridine-4,4',4 ''-tricarboxylic acid; dpbH=1,3-dipyridylbenzene; X=N(4-C6H4OMe)(2) ([2a](2-)), NPh2 ([2b](2-)), N-carbazolyl [2c](2-)) was synthesized and characterized. All complexes show broad absorption bands in the range 300-700 nm with a maximum at about 545 nm. Methyl esters [Ru(Me3tctpy)(dpb-X)](+) [1a](+)-[1c](+) are oxidized to the strongly coupled mixed-valent species [1a](2+)-[1c](2+) and the RuIII(aminium) complexes [1a](3+)-[1c](3+) at comparably low oxidation potentials. Theoretical calculations suggest an increasing spin delocalization between the metal center and the triarylamine unit in the order [1a]2(+)<[1b](2+)<[1c](2+). Solar cells were prepared with the saponified complexes [2a](2-)-[2c](2-) and the reference dye N719 as sensitizers using the I-3(-)/I- couple and [Co(bpy)3](3+/2+) and [Co(ddpd)2](3+/2+) couples as [B(C6F5)(4)](-) salts as electrolytes (bpy=2,2'-bipyridine; ddpd=N,N'-dimethyl-N,N'-dipyridin-2-yl-pyridine-2,6-diamine). Cells with [2c](2-) and I-3(-)/I- electrolyte perform similarly to cells with N719. In the presence of cobalt electrolytes, all efficiencies are reduced, yet under these conditions [2c](2-) outperforms N719.N