Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior

International audienceThe breast cancer resistance protein, also known as ABCG2, is one of the most highly studied ATP-binding cassette (ABC) transporters because of its ability to confer multidrug resistance. The lack of information on the physiological role of ABCG2 in humans severely limits cancer chemotherapeutic approaches targeting this transporter. We report here that ABCG2 comprises the molecular basis of a new blood group system (Junior, Jr) and that individuals of the Jr(a-) blood type have inherited two null alleles of ABCG2. We identified five frameshift and three nonsense mutations in ABCG2. We also show that the prevalence of the Jr(a-) blood type in the Japanese and European Gypsy populations is related to the p.Gln126* and p.Arg236* protein alterations, respectively. The identification of ABCG2(-/-) (Jr(a-)) individuals who appear phenotypically normal is an essential step toward targeting ABCG2 in cancer and also in understanding the physiological and pharmacological roles of this promiscuous transporter in humans

A review of Australia’s Mesozoic fishes

© 2020 Geological Society of Australia Inc., Australasian Palaeontologists. The Australian Mesozoic fish fauna is considered to be depauperate in comparison with fish faunas in the Northern Hemisphere. However, due to its geographical location as a potential radiation center in the Southern Hemisphere, Australia’s Mesozoic fish fauna is important for understanding fish radiations. Most of the modern fish groups originated during the Mesozoic, but the first records of a modern fish fauna (freshwater and marine) in Australia does not occur until the lower Paleogene. Here, we review all known fossil fish-bearing localities from the Mesozoic of Australia, to improve the understanding of the record. The apparent low Australian Mesozoic fish diversity is likely due to its understudied status of the constituent fossils rather than to a depauperate record. In addition, we review recent work with the aim of placing the Australian Mesozoic fish fauna in a global context. We review the taxonomy of Australian fossil fishes and conclude that the assignments of many actinopterygians need major revision within a modern phylogenetic context. The vast majority of chondrichthyans are yet to be formally described; to the contrary all of the known lungfish specimens have been described. This study considers the microscopic and fragmented remains of Mesozoic fish already found in Australia, allowing a more complete view of the diversity of the fishes that once inhabited this continent