Multidisciplinary Applications of Detached-Eddy Simulation to Separated Flows at High Reynolds Numbers

We focus on multidisciplinary applications of detached-eddy simulation (DES), principally flight mechanics and aeroelasticity. Specifically, the lateral instability (known as abrupt wing stall) of the preproduction F/A-18E is reproduced using DES, including the unsteady shock motion. The presence of low frequency pressure oscillations due to shock motion in the current simulations and the experiments motivated a full aircraft calculation, which showed low frequency high-magnitude rolling moments that could be a significant contributor to the abrupt wing stall phenomenon. DES is also applied to the F-18 high angle of attack research vehicle (HARV) at a moderate angle of attack to reproduce the vortex breakdown leading to vertical stabilizer buffet. Unsteady tail loads are compared to flight test data. This work lays the foundation for future deforming grid calculations to reproduce the aero-elastic tail buffet seen in flight test. Solution based grid adaption is used on unstructured grids in both cases to improve the resolution in the separated region. Previous DoD Challenge work has demonstrated the unique ability of the DES turbulence treatment to accurately and efficiently predict flows with massive separation at flight Reynolds numbers. DES calculations have been performed using the Cobalt code and on unstructured grids, an approach that can deal with complete configurations with very few compromises. A broad range of flows has been examined in previous Challenge work, including aircraft forebodies, airfoil sections, a missile afterbody, vortex breakdown on a delta wing, and the F-16 and F-15E at high angles-of-attack. All DES predictions exhibited a moderate to significant improvement over results obtained using traditional Reynolds-averaged models and often excellent agreement with experimental/flight-test data. DES combines the efficiency of a Reynolds-averaged turbulence model near the wall with the fidelity of Large-Eddy Simulation (LES) in separated regions. Since it uses Large-Eddy Simulation in the separated regions, it is capable of predicting the unsteady motions associated with separated flows. The development and demonstration of improved methods for the prediction of flight mechanics and aeroelasticity in this Challenge is expected to reduce the acquisition cost of future military aircraft

Missing the Mark? A Two Time Point Cohort Study Estimating Intestinal Parasite Prevalence in Informal Settlements in Lima, Peru

Objectives: The World Health Organization’s (WHO) recommendations list Peru as potentially needing prevention of soil-transmitted helminthiasis (STH). Prevalence of STH varies regionally and remains understudied in the newest informal settlements of the capital city, Lima. The purpose of this study was to evaluate the need for Mass Drug Administration (MDA) of antiparasitic drugs in the newest informal settlements of Lima. The aim of this study was to estimate the season-specific prevalence of STH to determine if these prevalence estimates met the WHO threshold for MDA in 3 informal settlements. Methods : A 2 time point cohort study was conducted among a sample of 140 children aged 1 to 10 years living in 3 purposively sampled informal settlements of Lima, Peru. Children were asked to provide 2 stool samples that were analyzed with the spontaneous sedimentation in tube technique. The season-specific prevalence proportions of MDA-targeted STH were estimated using a hidden (latent) Markov modeling approach to adjust for repeated measurements over the 2 seasons and the imperfect validity of the screening tests. Results : The prevalence of MDA targeted STH was low at 2.2% (95% confidence interval = 0.3% to 6%) and 3.8% (95% confidence interval = 0.7% to 9.3%) among children sampled in the summer and winter months, respectively, when using the most conservative estimate of test sensitivity. These estimates were below the WHO threshold for MDA (20%). Conclusions : Empiric treatment for STH by organizations active in the newest informal settlements is not supported by the data and could contribute to unnecessary medication exposures and poor allocation of resources