Methano­ldinitrato[N-(2-pyridylmethyl­ene)aniline]copper(II)

The Cu atom in the title compound, [Cu(NO3)2(C12H10N2)(CH3OH)], adopts a square-pyramidal geometry, being ligated by two N atoms of the bidentate N-(2-pyridylmethyl­ene)­aniline (ppma) ligand, two O atoms of NO3 ligands and one O atom of a methanol molecule, which occupies the apical position. The phenyl ring on the ppma ligand is twisted out of the pyridine plane, forming a dihedral angle of 42.9 (1)°. In the crystal, inter­molecular O—H⋯O hydrogen bonds between methanol and NO3 ligands form an extensive one-dimensional network extending parallel to [100]

Cell density-dependent differential proliferation of neural stem cells on omnidirectional nanopore-arrayed surface

112Ysciescopu

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK) orchestrates diabetic gene reprogramming via dysregulation of specific gene expression. Although many recent studies have focused on the development of non-classical agonist drugs that inhibit the phosphorylation of PPAR gamma at Ser273, the molecular mechanism of PPAR gamma dephosphorylation at Ser273 is not well characterized. Here, we report that protein phosphatase Mg2+/Mn2+-dependent 1A (PPM1A) is a novel PPAR gamma phosphatase that directly dephosphorylates Ser273 and restores diabetic gene expression which is dysregulated by pSer273. The expression of PPM1A significantly decreases in two models of insulin resistance: diet-induced obese (DIO) mice and db/db mice, in which it negatively correlates with pSer273. Transcriptomic analysis using microarray and genotype-tissue expression (GTEx) data in humans shows positive correlations between PPM1A and most of the genes that are dysregulated by pSer273. These findings suggest that PPM1A dephosphorylates PPAR gamma at Ser273 and represents a potential target for the treatment of obesity-linked metabolic disorders

5.IEEE-IGARSS in Seoul, Korea

Inha UniversityMODIS LAI product is very important because it has potential for the monitoring of global scale ecosystem, global change of carbon and water. This study aims to analyze the temporal variability of annual MODIS LAI product using field measured LAI dataset for four vegetation types. The MODIS annual LAI pattern shows the high variety or inaccuracy of LAI during rainy season over South Korea. This phenomenon is caused by high cloud coverage and fails of processing by a radiative transfer model in this rainy season. Annual LAI pattern estimated by a radiative transfer model has least variance of LAI values during this time. In coniferous forest, MODIS annual LAI pattern shows the abnormal decreasing of LAI during nongrowing season comparing with field-measured LAI. This decrease of LAI being an inaccurate phenomenon is caused by rather higher cloud coverage and decreasing of understory plants. MODIS LAI product in deciduous and grass coverage is underestimated by comparing with field-measured LAI. In rice paddy, MODIS LAI shows longer growing season than field measured LAI. For the accurate analysis of temporal MODIS LAI product, it needs considering of vegetation coverage types, cloud coverage, and algorithm types of MODIS LAI. © 2005 IEEE.Project Number 14404021, Peport of Research Project ; Grant-in-Aid for Scientific Research(B)(2), from April 2002 to March 2006, Edited by Muramoto,Ken-ichiroKamata, NaotoKawanishi, TakuyaKubo, MamoruLiu, JiyuanLee, Kyu-Sung , 人工衛星データ活用のための東アジアの植生調査、課題番号14404021, 平成14年度～平成17年度科学研究費補助金, 基盤研究（B)(2)研究成果報告書, 研究代表者：村本, 健一郎, 金沢大学自然科学研究科教

High performance polymer light-emitting diodes with N-type metal oxide/conjugated polyelectrolyte hybrid charge transport layers

We present an interfacial engineering strategy employing n-type-metal-oxide/conjugated-polyelectrolyte (CPE) hybrid charge-transport layers for highly efficient polymer light-emitting diodes (PLEDs). The hybrid metal-oxide/CPE layer facilitates electron-injection, while blocking hole-transport, and thereby maximizes electron-hole recombination within the emitting layer. A series of metal-oxide/CPE combinations were tested in inverted PLEDs (FTO/metal-oxide/CPF8BT/MoO3/Au). Specifically, HfO2/CPE double layer achieved an electroluminescence (EL) efficiency of up to 25.8 cd/A (@ 6.4 V, one of the highest values reported for fluorescent PLEDs).open11