Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice

<p>Abstract</p> <p>Background</p> <p>Extracts of <it>Hypericum perforatum </it>(St. John's wort) have been traditionally recommended for a wide range of medical conditions, in particular mild-to-moderate depression. The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration.</p> <p>Methods</p> <p>CD1 mice were submitted to 7 weeks corticosterone administration and then behavioral tests as Open Field (OF), Novelty-Suppressed Feeding (NSF), Forced Swim Test (FST) were performed. Cell proliferation in hippocampal dentate gyrus (DG) was investigated by both 5-bromo-2'-deoxyuridine (BrdU) and doublecortin (DCX) immunohistochemistry techniques and stereological procedure was used to quantify labeled cells. Golgi-impregnation method was used to evaluate changes in dendritic spines in DG. Hypericum perforatum (30 mg/Kg) has been administered for 3 weeks and then neural development in the adult hippocampus and behavioral changes have been examined.</p> <p>Results</p> <p>The anxiety/depressive-like state due to chronic corticosterone treatment was reversed by exogenous administration of Hypericum perforatum; the proliferation of progenitor cells in mice hippocampus was significantly reduced under chronic corticosterone treatment, whereas a long term treatment with Hypericum perforatum prevented the corticosterone-induced decrease in hippocampal cell proliferation. Corticosterone-treated mice exhibited a reduced spine density that was ameliorated by Hypericum perforatum administration.</p> <p>Conclusion</p> <p>These results provide evidence of morphological adaptations occurring in mature hippocampal neurons that might underlie resilient responses to chronic stress and contribute to the therapeutic effects of chronic Hypericum perforatum treatment.</p

Auditing Workflow Executions against Dataflow Policies

This paper presents IFAudit, an approach for the audit of data ow policies in workflow models. IFAudit encompasses three steps. First, propagation graphs are generated from workflows&apos; log data. They represent the explicit information flows caused, e.g., by data access and message-passing, that have occurred during the execution of the workflow. Second, dataflow policies expressing security and compliance requirements are formalized in a system-independent manner as a binary relation on the workflow principals. Third, an audit algorithm analyzes the propagation graphs against the policies and delivers evidence with regard to whether the workflow complies with them. Besides presenting the corresponding algorithms, the paper discusses possible extensions to address more general types of information flws

Falldokumentation zur Standortproblematik bei neugegruendeten und verlagerten Behoerden

TIB: AC 7266 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Integrierter Umweltschutz im Bereich der Holzwirtschaft. Hochwertiges Brettschichtholz aus Buchenholz Abschlussbericht

Available from TIB Hannover: F03B1145 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman