The Surveyor 5, 6, and 7 Flight Paths and Their Determination from Tracking Data

Surveyor 5, 6, and 7 flight paths and tracking data for space station location

The universal functorial equivariant Lefschetz invariant

We introduce the universal functorial equivariant Lefschetz invariant for endomorphisms of finite proper G-CW-complexes, where G is a discrete group. We use K_0 of the category of "phi-endomorphisms of finitely generated free RPi(G,X)-modules". We derive results about fixed points of equivariant endomorphisms of cocompact proper smooth G-manifolds.Comment: 33 pages; shortened version of the author's PhD thesis, supervised by Wolfgang Lueck, Westfaelische Wilhelms-Universitaet Muenster, 200

Behavior of shell-model configuration moments

An important input into reaction theory is the density of states or the level density. Spectral distribution theory (also known as nuclear statistical spectroscopy) characterizes the secular behavior of the density of states through moments of the Hamiltonian. One particular approach is to partition the model space into subspaces and find the moments in those subspaces; a convenient choice of subspaces are spherical shell-model configurations. We revisit these configuration moments and find, for complete $0\hbar\omega$ many-body spaces, the following behaviors: (a) the configuration width is nearly constant for all configurations; (b) the configuration asymmetry or third moment is strongly correlated with the configuration centroid; (c) the configuration fourth moment, or excess is linearly related to the square to the configuration asymmetry. Such universal behavior may allow for more efficient modeling of the density of states in a shell-model framework.Comment: 12 pages, 8 figure

Effect of Bio-Oss® Collagen and Collagen Matrix on Bone Formation

Objective: to compare the amount of new bone produced by Bio-Oss ® Collagen to that produced by collagen matrix in vivo. Method: eighteen bone defects, 5mm by 10mm were created in the parietal bone of 9 New Zealand White rabbits. 6 defects were grafted with Bio-Oss ® Collagen. 6 defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis. Results: A total of 339% more new bone was present in defects grafted with Bio-Oss ® Collagen than those grafted with collagen matrix (positive control). No bone was formed in the negative control group. Conclusion: Bio-Oss ® Collagen has the effect of stimulating new bone formation locally compared with collagen matrix in vivo. Bio-Oss ® Collagen may be utilized as a bone graft material. © Wong and Rabie; Licensee Bentham Open.published_or_final_versio

The effect of Housing Status on Labor Market Outcomes

In the past, urban planning has often favored strict zoning, segregating residential areas from commercial-industrial areas. One unanticipated negative consequence of this strategy is a possible link between unemployment and housing status, suggested by Oswald in an important and controversial 1997 paper. He believes that home ownership reduces labor mobility, thereby creating disequilibrium and unemployment in regional labor markets. Compared with European countries and the United States-- the focuses of most empirical studies on the topic-- Hong Kong is decidedly more compact. Much of the city is covered by a rather efficient transportation system, making it unlikely as a choice for testing the Oswald hypothesis. However, over the years, a combination of factors, including escalating property …postprin

The Surveyor 3 and Surveyor 4 flight paths and their determination from tracking data

Surveyor 3 and 4 spacecraft flight path

In vivo imaging of protease activity by Probody therapeutic activation.

Probody™ therapeutics are recombinant, proteolytically-activated antibody prodrugs, engineered to remain inert until activated locally by tumor-associated proteases. Probody therapeutics exploit the fundamental dysregulation of extracellular protease activity that exists in tumors relative to healthy tissue. Leveraging the ability of a Probody therapeutic to bind its target at the site of disease after proteolytic cleavage, we developed a novel method for profiling protease activity in living animals. Using NIR optical imaging, we demonstrated that a non-labeled anti-EGFR Probody therapeutic can become activated and compete for binding to tumor cells in vivo with a labeled anti-EGFR monoclonal antibody. Furthermore, by inhibiting matriptase activity in vivo with a blocking-matriptase antibody, we show that the ability of the Probody therapeutic to bind EGFR in vivo was dependent on protease activity. These results demonstrate that in vivo imaging of Probody therapeutic activation can be used for screening and characterization of protease activity in living animals, and provide a method that avoids some of the limitations of prior methods. This approach can improve our understanding of the activity of proteases in disease models and help to develop efficient strategies for cancer diagnosis and treatment