Human infection by avian influenza A H5N1

The Southeast Asian outbreak of the highly lethal avian influenza A HSN1 infection in humans is unlikely to abate because of the enormous number of backyard farms providing poultry as the main source of food protein in developing countries. This increases the risk of the emergence of a reassortant pandemic influenza virus with improved human-to-human transmissibility. Currently triage of suspected cases by epidemiological risk factors remains the only practical way of case identification for laboratory investigation and infection control. The clinical usefulness of rapid diagnostic laboratory tests requires more vigorous evaluation. The lethality of this disease may reflect systemic viral dissemination, cytokine storm, or alveolar flooding due to inhibition of cellular sodium channels. The present circulating genotype Z is intrinsically resistant to amantadine and rimantadine. Prognosis may be improved by early treatment with a neuraminidase inhibitor with good systemic drug levels, and post-exposure prophylaxis for health care workers is recommended. The role of immunomodulators and other modalities of therapy requires evaluation in randomised controlled trials, with prospective monitoring of the viral load and cytokine profiles in various clinical specimens. In view of the high fatality of the disease, a combination of contact, droplet, and airborne precautions are recommended as long as resources allow despite the fact that the relative importance of these three modes in nosocomial transmission of avian influenza is still unknown.published_or_final_versio

Penicillium marneffei recombinant antigen Mp1p and penicilliosis marneffei in HIV and non-HIV patients

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Red imported fire ants in Hong Kong

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Avian influenza A/H5N1 virus: Management in human and bird

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An intelligent tropical cyclone eye fix system using motion field analysis

Tropical cyclones (TCs) are weather systems with vast destructive power. Accurate location of their circulation centers, or "eyes", is thus important to forecasters. However, the eye fix process is often done manually in practice. While multiple factors are considered in the process, with subjective elements in these methods, forecasters could disagree. This paper describes a TC eye fix system that uses a novel motion field structure analysis method. It can handle TCs without well-defined structure that are partially out of the image. The systems also adapts user inputs and past results to improve its accuracy. Implemented on a commodity desktop computer, the system can process about 5 images per minute, giving an average error of about 0.16 degrees in latitude/longitude on Mercator projected map for TCs that are completely inside the radar image. This is well within the relative error of about 0.3-0.4 degrees given by different TC warning centers. This TC eye fix system is useful in giving an objective TC center location in contrast to traditional manual analysis. © 2005 IEEE.published_or_final_versio

Fast rotation center identification methods for video sequences

Rotational motion can often be seen in video. However, comparatively little research has been done to investigate rotational motions in video, whose analysis could be useful. For example, if we can efficiently identify the rotation center of a spinning object, extraction and tracking of it can be made easier by grouping points moving at the same radial speed. It could also improve compression by synthesizing analyzed spin transitions, and help tracking of rotating objects. In this paper, we introduce a set of rotation center location methods using only the motion field constructed during video encoding, along with a few methods for improving their performances. These methods can be implemented using integer operations only. They are up to 1.81 times faster than the traditional circulation analysis method with little sacrifice in accuracy, and are not affected by asymmetric fields caused by translational motions. © 2005 IEEE.published_or_final_versio

Influenza vaccination: Options and issues

Currently available vaccines have similar efficacy if they are matched to the most prevalent circulating strains. They also have comparable adverse effect profiles. The choice of a specific preparation of vaccine therefore requires consideration of cost, purity of the vaccine preparation in terms of the amount of egg protein and endotoxin, allergy to different constituents of the vaccine, reactogenicity profiles, as well as the preferred route of administration. Intradermal injection of the vaccine appears to be a viable alternative to the traditional intramuscular administration with the additional benefit of requiring a smaller volume of vaccine. Despite the documented benefits in various community and institutional settings, influenza vaccination has been underutilised by most target groups. A major obstacle to broader coverage of vaccination is the perceived ineffectiveness of the vaccine and the relatively benign nature of the illness in most patients. Uptake of vaccine among target populations, especially health care workers, needs to be improved through a concerted effort between frontline clinicians and health authorities.published_or_final_versio

Patient-specific instrument can achieve same accuracy with less resection time than navigation assistance in periacetabular pelvic tumor surgery: A cadaveric study

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Effectiveness of Educational Poster on Knowledge of Emergency Management of Dental Trauma - Part 2: Cluster Randomised Controlled Trial for Secondary School Students

Objective To investigate the effectiveness of educational poster on improving secondary school students' knowledge of emergency management of dental trauma. Methods A cluster randomised controlled trial was conducted. 16 schools with total 671 secondary students who can read Chinese or English were randomised into intervention (poster, 8 schools, 364 students) and control groups (8 schools, 305 students) at the school level. Baseline knowledge of dental trauma was obtained by a questionnaire. Poster containing information of dental trauma management was displayed in a classroom for 2 weeks in each school in the intervention group whereas in the control group there was no display of such posters. Students of both groups completed the same questionnarie after 2 weeks. Results Two-week display of posters improved the knowledge score by 1.25 (p-value = 0.0407) on average. Conclusion Educational poster on dental trauma management significantly improved the level of knowledge of secondary school students in Hong Kong.published_or_final_versio

Postablation stimulated thyroglobulin level is an important predictor of biochemical complete remission after reoperative cervical neck dissection in persistent/recurrent papillary thyroid carcinoma

BACKGROUND: The efficacy of reoperative cervical neck dissection (RND) in achieving biochemical complete remission (BCR) (or postreoperation stimulated thyroglobulin [sTg] of 2 ng/mL) were correlated with the postreoperation sTg levels after RNDs. Patients' clinicopathological characteristics, operative findings, and subsequent RNDs were compared between those with BCR after RNDs and those without. RESULTS: Those with postablation sTg levels of 2 ng/mL. Overall BCR gradually decreased after each subsequent RND. Postablation sTg significantly correlated with postreoperation sTg (rho = 0.509, p < 0.001). After adjusting for the number of metastatic lymph nodes excised at first RND and presence of extranodal extension, postablation sTg of </= 0.2 ng/mL was the only independent factor for BCR after one or more RNDs (odds ratio 37.0, 95 % confidence interval 5.68-250.0, p = 0.001). CONCLUSIONS: Only a third of patients who underwent one or more RNDs for persistent/recurrent PTC had BCR afterward. Postablation sTg level was an independent factor for BCR. Completeness of the initial operation is important for the subsequent success of RND.published_or_final_versio